MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma

International Journal of Oncology

Volumn 43, Issue 2, 2013, Pages 661-669

  Zhou, Liang ^a   Yang, Zhao Xu ^b   Song, Wen Jie ^b   Li, Qing Jun ^b   Yang, Fan ^b   Wang, De Sheng ^b   Zhang, Ning ^b   Dou, Ke Feng ^b  

^a The 155 Central Hospital of PLA   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cancer stem cell; Hepatocellular carcinoma; Invasion; microRNA 21; Migration; Side population

Indexed keywords

MESSENGER RNA; MICRORNA 21; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ACTIN POLYMERIZATION; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL INVASION; CELL ISOLATION; CELL MIGRATION; CELL MOTILITY; CELL POPULATION; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIDE POPULATION CELL;

APOPTOSIS REGULATORY PROTEINS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GPI-LINKED PROTEINS; HUMANS; LIVER NEOPLASMS; MICRORNAS; NEOPLASM INVASIVENESS; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSFECTION;

EID: 84879678207     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1965     Document Type: Article

References (52)

1. Lau WY and Lai EC: Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int 7: 237-257, 2008.
2. Visvader JE and Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768, 2008.
3. Simeone DM: Pancreatic cancer stem cells: implications for the treatment of pancreatic cancer. Clin Cancer Res 14: 5646-5648, 2008.
4. Ho MM, Ng AV, Lam S and Hung JY: Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 67: 4827-4833, 2007. (Pubitemid 46910191)
5. Prince ME, Sivanandan R, Kaczorowski A, et al: Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 104: 973-978, 2007. (Pubitemid 46154721)
6. Wang J, Guo LP, Chen LZ, Zeng YX and Lu SH: Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res 67: 3716-3724, 2007. (Pubitemid 46762157)
7. Goodell MA, Brose K, Paradis G, Conner AS and Mulligan RC: Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183: 1797-1806, 1996. (Pubitemid 26134320)
8. Kondo T, Setoguchi T and Taga T: Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA 101: 781-786, 2004. (Pubitemid 38121035)
9. Kruger M, Schwarz A and Blumich B: Investigations of silicone breast implants with the NMR-MOUSE. Magn Reson Imaging 25: 215-218, 2007. (Pubitemid 46162053)
10. Mitsutake N, Iwao A, Nagai K, et al: Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively. Endocrinology 148: 1797-1803, 2007. (Pubitemid 46457095)
11. Zhang N, Li R, Tao KS, et al: Characterization of a stem-like population in hepatocellular carcinoma MHCC97 cells. Oncol Rep 23: 827-831, 2010.
12. Ambros V: MicroRNA pathways in flies and worms: growth, death, fat, stress and timing. Cell 113: 673-676, 2003.
13. Liu C, Yu J, Yu S, et al: MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. J Hepatol 53: 98-107, 2010.
14. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658, 2007. (Pubitemid 47187346)
15. Asangani IA, Rasheed SA, Nikolova DA, et al: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-2136, 2008. (Pubitemid 351485639)
16. Gabriely G, Wurdinger T, Kesari S, et al: MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 28: 5369-5380, 2008.
17. Dean M, Fojo T and Bates S: Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-284, 2005. (Pubitemid 40488633)
18. Devreotes P and Janetopoulos C: Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem 278: 20445-20448, 2003. (Pubitemid 36806338)
19. Tang DJ, Dong SS, Ma NF, et al: Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology 51: 1255-1263, 2010.
20. Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer and cancer stem cells. Nature 414: 105-111, 2001.
21. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003. (Pubitemid 36418143)
22. Matsui W, Huff CA, Wang Q, et al: Characterization of clonogenic multiple myeloma cells. Blood 103: 2332-2336, 2004. (Pubitemid 38326254)
23. Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004. (Pubitemid 39551674)
24. Szotek PP, Pieretti-Vanmarcke R, Masiakos PT, et al: Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness. Proc Natl Acad Sci USA 103: 11154-11159, 2006. (Pubitemid 44156488)
25. Ambros V: The functions of animal microRNAs. Nature 431: 350-355, 2004.
26. Lu J, Getz G, Miska EA, et al: MicroRNA expression profiles classify human cancers. Nature 435: 834-838, 2005. (Pubitemid 40839735)
27. Iorio MV, Visone R, Di Leva G, et al: MicroRNA signatures in human ovarian cancer. Cancer Res 67: 8699-8707, 2007. (Pubitemid 47437445)
28. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism and function. Cell 116: 281-297, 2004.
29. Bloomston M, Frankel WL, Petrocca F, et al: MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 297: 1901-1908, 2007. (Pubitemid 46707844)
30. Feber A, Xi L, Luketich JD, et al: MicroRNA expression profiles of esophageal cancer. J Thorac Cardiovasc Surg 135: 255-260, 2008.
31. Yanaihara N, Caplen N, Bowman E, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9: 189-198, 2006. (Pubitemid 43357945)
32. Krichevsky AM and Gabriely G: miR-21: a small multi-faceted RNA. J Cell Mol Med 13: 39-53, 2009.
33. Grunder E, D'Ambrosio R, Fiaschetti G, et al: MicroRNA-21 suppression impedes medulloblastoma cell migration. Eur J Cancer 47: 2479-2490, 2011.
34. Li J, Yen C, Liaw D, et al: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science 275: 1943-1947, 1997. (Pubitemid 27148818)
35. Salmena L, Carracedo A and Pandolfi PP: Tenets of PTEN tumor suppression. Cell 133: 403-414, 2008. (Pubitemid 351622014)
36. Bedolla R, Prihoda TJ, Kreisberg JI, et al: Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin Cancer Res 13: 3860-3867, 2007. (Pubitemid 47037592)
37. Yoshimoto M, Cunha IW, Coudry RA, et al: FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Br J Cancer 97: 678-685, 2007. (Pubitemid 47339893)
38. Yu J, Zhang SS, Saito K, et al: PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J 28: 21-33, 2009.
39. Noda M, Oh J, Takahashi R, Kondo S, Kitayama H and Takahashi C: RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling. Cancer Metastasis Rev 22: 167-175, 2003. (Pubitemid 36561056)
40. Takahashi C, Sheng Z, Horan TP, et al: Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci USA 95: 13221-13226, 1998. (Pubitemid 28509552)
41. Clark JC, Thomas DM, Choong PF and Dass CR: RECK - a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer. Cancer Metastasis Rev 26: 675-683, 2007. (Pubitemid 350115122)
42. Noda M and Takahashi C: Recklessness as a hallmark of aggressive cancer. Cancer Sci 98: 1659-1665, 2007. (Pubitemid 47487898)
43. Kotzsch M, Farthmann J, Meye A, et al: Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer. Eur J Cancer 41: 2760-2768, 2005. (Pubitemid 41607570)
44. Takenaka K, Ishikawa S, Kawano Y, et al: Expression of a novel matrix metalloproteinase regulator, RECK and its clinical significance in resected non-small cell lung cancer. Eur J Cancer 40: 1617-1623, 2004. (Pubitemid 38757753)
45. Allgayer H: Pdcd4, a colon cancer prognostic that is regulated by a microRNA. Crit Rev Oncol Hematol 73: 185-191, 2010.
46. Cmarik JL, Min H, Hegamyer G, et al: Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci USA 96: 14037-14042, 1999.
47. Jansen AP, Camalier CE and Colburn NH: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res 65: 6034-6041, 2005. (Pubitemid 40994387)
48. Lankat-Buttgereit B and Goke R: The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol Cell 101: 309-317, 2009.
49. Yang HS, Matthews CP, Clair T, et al: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Mol Cell Biol 26: 1297-1306, 2006. (Pubitemid 43202557)
50. Wang Q, Sun Z and Yang HS: Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells. Oncogene 27: 1527-1535, 2008. (Pubitemid 351347877)
51. Nieves-Alicea R, Colburn NH, Simeone AM and Tari AM: Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinase-2 expression. Breast Cancer Res Treat 114: 203-209, 2009.
52. Zhang S, Li J, Jiang Y, Xu Y and Qin C: Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells. J Exp Clin Cancer Res 28: 71, 2009.