Effects of epidural neostigmine and clonidine in labor analgesia: A systematic review and meta-analysis

Journal of Obstetrics and Gynaecology Research

Volumn 41, Issue 2, 2015, Pages 214-221

  Zhang, Ning ^a   Xu, Ming Jun ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

clonidine; combined spinal epidural; labor analgesia; meta analysis; neostigmine

Indexed keywords

CLONIDINE; LOCAL ANESTHETIC AGENT; NEOSTIGMINE; OPIATE;

ANALGESIC ACTIVITY; APGAR SCORE; ARTICLE; CASE CONTROL STUDY; CESAREAN SECTION; COMPARATIVE STUDY; DRUG EFFICACY; DRUG SAFETY; EPIDURAL ANESTHESIA; HUMAN; INSTRUMENTAL DELIVERY; LABOR; META ANALYSIS; OBSTETRIC ANALGESIA; SPINAL ANESTHESIA; SYSTEMATIC REVIEW; VISUAL ANALOG SCALE; FEMALE; LABOR PAIN; NEWBORN; OBSTETRIC ANESTHESIA; OBSTETRIC DELIVERY; PAIN MEASUREMENT; PREGNANCY; PROCEDURES;

ANESTHESIA, EPIDURAL; ANESTHESIA, OBSTETRICAL; ANESTHETICS, LOCAL; APGAR SCORE; CLONIDINE; DELIVERY, OBSTETRIC; FEMALE; HUMANS; INFANT, NEWBORN; LABOR PAIN; NEOSTIGMINE; PAIN MEASUREMENT; PREGNANCY;

EID: 84921652529     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/jog.12517     Document Type: Article

References (37)

1. Crouch D, Merry ES,. Epidural analgesia for caesarean section. Br J Anaesth 1946; 20: 24-33.
2. Mayberry LJ, Clemmens D, De A,. Epidural analgesia side effects, co-interventions, and care of women during childbirth: A systematic review. Am J Obstet Gynecol 2002; 186: S81-S93.
3. Simmons SW, Cyna AM, Dennis AT, Hughes D,. Combined spinal-epidural versus epidural analgesia in labour. Cochrane Database Syst Rev 2007; (3): CD003401.
4. Crowhurst J, Stocks G,. Combined spinal-epidural (CSE) and its modifications-75 years on. Anaesth Intensive Care 2012; 40: 757-759.
5. Pascual-Ramirez J, Haya J, Pérez-Lõpez FR, Gil-Trujillo S, Garrido-Esteban RA, Bernal G,. Effect of combined spinal-epidural analgesia versus epidural analgesia on labor and delivery duration. Int J Gynaecol Obstet 2011; 114: 246-250.
6. Booth JL, Pan PH,. Combined spinal epidural or traditional epidural technique: Who wins? Anesth Analg 2013; 116: 515-516.
7. Roelants F,. The use of neuraxial adjuvant drugs (neostigmine, clonidine) in obstetrics. Curr Opin Anaesthesiol 2006; 19: 233-237.
8. Habib AS, Gan TJ,. Use of neostigmine in the management of acute postoperative pain and labour pain: A review. CNS Drugs 2006; 20: 821-839.
9. Roelants F, Lavand'homme PM,. Epidural neostigmine combined with sufentanil provides balanced and selective analgesia in early labor. Anesthesiology 2004; 101: 439-444.
10. Wallet F, Clement HJ, Bouret C, et al. Effects of a continuous low-dose clonidine epidural regimen on pain, satisfaction and adverse events during labour: A randomized, double-blind, placebo-controlled trial. Eur J Anaesthesiol 2010; 27: 441-447.
11. Dewandre P-Y, Decurninge V, Bonhomme V, Hans P, Brichant J-F,. Side effects of the addition of clonidine 75 μg or sufentanil 5 μg to 0.2% ropivacaine for labour epidural analgesia. Int J Obstet Anesth 2010; 19: 149-154.
12. Missant C, Teunkens A, Vandermeersch E, Van de Velde M,. Intrathecal clonidine prolongs labour analgesia but worsens fetal outcome: A pilot study. Can J Anaesth 2004; 51: 696-701.
13. Dewandre PY, Decurninge V, Bonhomme V, Hans P, Brichant JF,. Side effects of the addition of clonidine 75 microg or sufentanil 5 microg to 0.2% ropivacaine for labour epidural analgesia. Int J Obstet Anesth 2010; 19: 149-154.
14. King M, Milazkiewicz R, Carli F, Deacock A,. Influence of neostigmine on postoperative vomiting. Br J Anaesth 1988; 61: 403-406.
15. Costa-Martins JM, Pereira M, Martins H, Moura-Ramos M, Coelho R, Tavares J,. Attachment styles, pain and the consumption of analgesics during labour: A prospective observational study. J Pain 2014; 15: 304-311.
16. Mak P, Campbell R, Irwin M,. The ASA physical status classification: Inter-observer consistency. American Society of Anesthesiologists. Anaesth Intensive Care 2002; 30: 633-640.
17. Van de Velde M, Berends N, Kumar A, et al. Effects of epidural clonidine and neostigmine following intrathecal labour analgesia: A randomised, double-blind, placebo-controlled trial. Int J Obstet Anesth 2009; 18: 207-214.
18. Boogmans T, Vertommen J, Valkenborgh T, Devroe S, Roofthooft E, Van de Velde M,. Epidural neostigmine and clonidine improves the quality of combined spinal epidural analgesia in labour: A randomised, double-blind controlled trial. Eur J Anaesthesiol 2014; 31: 190-196.
19. Owen MD, Özsaraç Ö, Sahin S, Uçkunkaya N, Kaplan N, Magunaci I,. Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia. Anesthesiology 2000; 92: 361-366.
20. Hui G, Xuefeng S, Yingmin Z,. Combination of clonidine, neostigmine and ropivacaine in epidural labor analgesia. Infect Inflamm Rep 2007; 8: 166-168.
21. Gambling D, Berkowitz J, Farrell TR, Pue A, Shay D,. A randomized controlled comparison of epidural analgesia and combined spinal-epidural analgesia in a private practice setting: Pain scores during first and second stages of labor and at delivery. Anesth Analg 2013; 116: 636-643.
22. Ginosar Y, Riley ET, Angst MS,. Analgesic and sympatholytic effects of low-dose intrathecal clonidine compared with bupivacaine: A dose-response study in female volunteers. Br J Anaesth 2013; 111: 256-263.
23. Reid J, Dargie H, Davies D, Wing L, Hamilton C, Dollery C,. Clonidine withdrawal in hypertension: Changes in blood-pressure and plasma and urinary noradrenaline. Lancet 1977; 309: 1171-1174.
24. Eisenach J, Detweiler D, Hood D,. Hemodynamic and analgesic actions of epidurally administered clonidine. Anesthesiology 1993; 78: 277-287.
25. Hansen TG, Henneberg SW, Walther-Larsen S, Lund J, Hansen M,. Caudal bupivacaine supplemented with caudal or intravenous clonidine in children undergoing hypospadias repair: A double-blind study. Br J Anaesth 2004; 92: 223-227.
26. Meston CM, Gorzalka BB, Wright JM,. Inhibition of subjective and physiological sexual arousal in women by clonidine. Psychosom Med 1997; 59: 399-407.
27. Salih M, Mustafa A, Oystreck D, Attia K,. Ocular neostigmine drops for diagnosing myasthenia gravis. J Neurol Neurophysiol 2012; S11: 1-4.
28. Mahajan R, Grover VK, Chari P,. Caudal neostigmine with bupivacaine produces a dose-independent analgesic effect in children. Can J Anaesth 2004; 51: 702-706.
29. Zhu W, Umegaki H, Yoshimura J, et al. The elevation of plasma adrenocorticotrophic hormone and expression of c-Fos in hypothalamic paraventricular nucleus by microinjection of neostigmine into the hippocampus in rats: Comparison with acute stress responses. Brain Res 2001; 892: 391-395.
30. Hood DD, Mallak KA, Eisenach JC, Tong C,. Interaction between intrathecal neostigmine and epidural clonidine in human volunteers. Anesthesiology 1996; 85: 315-325.
31. Naguib M, Yaksh TL,. Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with [mu] and [alpha] 2 receptor systems. Anesthesiology 1994; 80: 1338-1348.
32. Roelants F, Lavand'homme PM, Mercier-Fuzier V,. Epidural administration of neostigmine and clonidine to induce labor analgesia: Evaluation of efficacy and local anesthetic-sparing effect. Anesthesiology 2005; 102: 1205-1210.
33. Pöpping DM, Elia N, Wenk M, Tramèr MR,. Combination of a reduced dose of an intrathecal local anesthetic with a small dose of an opioid. A meta-analysis of randomized trials. Pain 2013; 154: 1383-1390.
34. Arzola C, Wieczorek P,. Efficacy of low-dose bupivacaine in spinal anaesthesia for Caesarean delivery: Systematic review and meta-analysis. Br J Anaesth 2011; 107: 308-318.
35. Larbuisson L, Senard M, Damas P, Preiser J, Lamy M,. Anesthesia and research meeting. Acta Anaesthesiol Belg 2007; 58: 65-84.
36. Williams JS, Tong C, Eisenach JC,. Neostigmine counteracts spinal clonidine-induced hypotension in sheep. Anesthesiology 1993; 78: 301-307.
37. Geelen K, Kuypers M, Deprest J, De Buck F, Van De Velde M,. Effects of epidural clonidine an neostigmine on the quality of epidural labour analgesia using a local anaesthetic/opioid mixture: A placebo-controlled, double blind trial. Eur J Anaesthesiol 2008; 11 (AP 1-4): 159-160.