Side effects of the addition of clonidine 75 μg or sufentanil 5 μg to 0.2% ropivacaine for labour epidural analgesia

International Journal of Obstetric Anesthesia

Volumn 19, Issue 2, 2010, Pages 149-154

  Dewandre, P Y ^a   Decurninge, V ^a   Bonhomme, V ^a   Hans, P ^a   Brichant, J F ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Analgesia; Clonidine; Epidural; Labour; Ropivacaine; Sufentanil

Indexed keywords

CLONIDINE; EPHEDRINE; ROPIVACAINE; SUFENTANIL;

ADULT; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; EPIDURAL ANESTHESIA; FEMALE; FETUS HEART RATE; HUMAN; HYPOTENSION; LABOR; MAJOR CLINICAL STUDY; MOTOR NERVE BLOCK; NAUSEA; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT;

ADULT; AMIDES; ANALGESIA, EPIDURAL; ANALGESICS; ANESTHESIA, OBSTETRICAL; ANESTHETICS, LOCAL; CLONIDINE; DOUBLE-BLIND METHOD; FEMALE; FLUID THERAPY; HUMANS; PREGNANCY; PROSPECTIVE STUDIES; PRURITUS; SUFENTANIL;

EID: 77949567374     PISSN: 0959289X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijoa.2009.08.003     Document Type: Article

References (30)

1. Chestnut D.H., Owen C.L., Bates J.N., Ostman L.G., Choi W.W., and Geiger M.W. Continuous infusion epidural analgesia during labor: a randomized, double-blinded comparison of 0.0625% bupivacaine/0.0002% fentanyl versus 0.125% bupivacaine. Anesthesiology 68 (1988) 754-759
2. Vertommen J.D., Vandermeulen E., Van Aken H., et al. The effects of the addition of sufentanil to 0.125% bupivacaine on the quality of analgesia during labor and on the incidence of instrumental deliveries. Anesthesiology 74 (1991) 809-814
3. Comparative Obstetric Mobile Epidural Trial (COMET) Study Group UK. Effect of low-dose mobile versus traditional epidural techniques on mode of delivery: a randomised controlled trial. Lancet 2001;358:19-23.
4. Comparative Obstetric Mobile Epidural Trial (COMET) Study Group UK. Randomized controlled trial comparing traditional with two "mobile" epidural techniques. Anesthetic and analgesic efficacy. Anesthesiology 2002;97:1567-75.
5. Burnstein R., Buckland R., and Pickett J.A. A survey of epidural analgesia for labour in the United Kingdom. Anaesthesia 54 (1999) 634-640
6. O'Meara M.E., and Gin T. Comparison of 0.125% bupivacaine with 0.125% bupivacaine and clonidine as extradural analgesia in the first stage of labour. Br J Anaesth 71 (1993) 651-656
7. Le Polain B., De Kock M., Scholtes J.L., and Van Lierde M. Clonidine combined with sufentanil and bupivacaine with adrenaline for obstetric analgesia. Br J Anaesth 71 (1993) 657-660
8. Celleno D., Capogna G., Costantino P., and Zangrillo A. Comparison of fentanyl with clonidine as adjuvants for epidural analgesia with 0.125% bupivacaine in the first stage of labor. Int J Obstet Anesth 4 (1995) 26-29
9. Cigarini I., Kaba A., Bonnet F., et al. Epidural clonidine combined with bupivacaine for analgesia in labor. Effects on mother and neonate. Reg Anesth 20 (1995) 113-120
10. Chassard D., Mathon L., Dailler F., Golfier F., Tournade J.P., and Bouletreau P. Extradural clonidine combined with sufentanil and 0.0625% bupivacaine for analgesia in labour. Br J Anaesth 77 (1996) 458-462
11. 2-adrenergic agonists for regional anaesthesia: a clinical review of clonidine (1984-1995). Anesthesiology 85 (1996) 655-674
12. Claes B., Soetens M., Van Zundert A., and Datta S. Clonidine added to bupivacaine-epinephrine-sufentanil improves epidural analgesia during childbirth. Reg Anesth Pain Med 23 (1998) 540-547
13. Tremlett M.R., Kelly P.J., Parkins J., Hughes D., and Redfern N. Low-dose clonidine infusion during labour. Br J Anaesth 83 (1999) 257-261
14. Paech M.J., Pavy T.J., Orlikowski C.E., and Evans S.F. Patient-controlled epidural analgesia in labor: the addition of clonidine to bupivacaine-fentanyl. Reg Anesth Pain Med 25 (2000) 34-40
15. Kizilarslan S., Kuvaki B., Onat U., and Sagiroglu E. Epidural fentanyl-bupivacaine compared with clonidine-bupivacaine for analgesia in labour. Eur J Anaesthesiol 17 (2000) 692-697
16. Landau R., Schiffer E., Morales M., Savoldelli G., and Kern C. The dose-sparing effect of clonidine added to ropivacaine for labor epidural analgesia. Anesth Analg 95 (2002) 728-734
17. Aveline C., El Metaoua S., Masmoudi A., Boelle P.Y., and Bonet F. The effect of clonidine on the minimum local analgesic concentration of epidural ropivacaine during labor. Anesth Analg 95 (2002) 735-740
18. Lyons G., Columb M., Hawthorne L., and Dresner M. Extradural pain relief in labour: bupivacaine sparing by extradural fentanyl is dose dependent. Br J Anaesth 78 (1997) 493-497
19. Polley L.S., Columb M.O., Wagner D.S., and Naughton N.N. Dose-dependent reduction of the minimum local analgesic concentration of bupivacaine by sufentanil for epidural analgesia in labor. Anesthesiology 89 (1998) 626-632
20. Bernard J.M., Le Roux D., Barthe A., Jourdain O., Vizquel L., and Michel C. The dose-range effects of sufentanil added to 0.125% bupivacaine on the quality of patient-controlled epidural analgesia during labor. Anesth Analg 92 (2001) 184-188
21. Dewandre P.Y., Kirsch M., Bonhomme V., Columb M., Hans P., and Brichant J.F. Impact of the addition of sufentanil 5 μg or clonidine 75 μg on the minimum local analgesic concentration of ropivacaine for epidural analgesia in labour: a randomized comparison. Int J Obstet Anesth 17 (2008) 315-321
22. Debon R., Allaouchiche B., Duflo F., Boselli E., and Chassard D. The analgesic effects of sufentanil combined with ropivacaine 0.2% for labor analgesia: a comparison of three sufentanil doses. Anesth Analg 92 (2001) 180-183
23. Benhamou D., Mercier F.J., Ben Ayed M., and Auroy Y. Continuous epidural analgesia with bupivacaine 0.125% or bupivacaine 0.0625% plus sufentanil 0.25 μg/ml: a study in singleton breech presentation. Int J Obstet Anesth 11 (2002) 13-18
24. Beilin Y., Galea M., and Bodian C.A. Epidural ropivacaine for the initiation of labor epidural analgesia: a dose finding study. Anesth Analg 88 (1999) 1340-1345
25. Paech M.J. Patient-controlled epidural analgesia in labour: is a continuous infusion of benefits?. Anaesth Intensive Care 20 (1992) 15-20
26. Boselli E., Debon R., Cimino Y., Rimmelé T., Allaouchiche B., and Chassard D. Background infusion is not beneficial during labor patient-controlled analgesia with 0.1% ropivacaine plus 0.5 μg/ml sufentanil. Anesthesiology 100 (2004) 968-972
27. Bremerich D., Waibel H.J., Mierdl S., et al. Comparison of continuous background infusion plus demand dose and demand-only parturient-controlled epidural analgesia using ropivacaine combined with sufentanil for labor and delivery. Int J Obstet Anesth 14 (2005) 114-120
28. Missant C., Teunkenst A., Vandermeersch E., and Van de Velde M. Patient-controlled epidural analgesia following combined spinal-epidural analgesia in labour: the effects of adding a continuous epidural infusion. Anaesth Intensive Care 33 (2005) 452-456
29. Cooper D.W., Carpenter M., Mowbray P., Desira W.R., Ryall D.M., and Kokri M.S. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for caesarean delivery. Anesthesiology 97 (2002) 1582-1590
30. Missant C., Teunkens A., Vandermeersch E., and Van de Velde M. Intrathecal clonidine prolongs labour analgesia but worsens fetal outcome: a pilot study. Can J Anesth 51 (2004) 696-701