Epidural administration of neostigmine and clonidine to induce labor analgesia: Evaluation of efficacy and local anesthetic-sparing effect

Anesthesiology

Volumn 102, Issue 6, 2005, Pages 1205-1210

  Roelants, Fabienne ^a   Lavand'homme, Patricia M ^a   Mercier Fuzier, Valérie ^a,b  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b Paul Sabatier University   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CLONIDINE; EPHEDRINE; NEOSTIGMINE; ROPIVACAINE; SUFENTANIL;

ACETYLCHOLINE RELEASE; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONTINUOUS EPIDURAL ANESTHESIA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; EPIDURAL ANESTHESIA; FEMALE; HUMAN; HYPOTENSION; LABOR; MOTOR DYSFUNCTION; NAUSEA AND VOMITING; NORMAL HUMAN; OBSTETRIC ANALGESIA; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; VISUAL ANALOG SCALE;

ANESTHESIA, EPIDURAL; ANESTHETICS, LOCAL; CLONIDINE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LABOR PAIN; NEOSTIGMINE; PAIN MEASUREMENT; PREGNANCY;

EID: 19744376122     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200506000-00021     Document Type: Article

References (29)

1. Benhamou D: Are local anesthetics needed for local anesthesia? ANESTHESIOLOGY 2004; 101:271-2
2. Sharma S, McIntire D, Wiley J, Leveno K: Labor analgesia and cesarean delivery: An individual patient meta-analysis of nulliparous women. ANESTHESIOLOGY 2004; 100:142-8
3. Aveline C, El Metaoua S, Masmoudi A, Boelle PY, Bonnet F: The effect of clonidine on the minimum local analgesic concentration of epidural ropivacaine during labor. Anesth Analg 2002; 95:735-40
4. Landau R, Schiffer E, Morales M, Savoldelli G, Kern C: The dose-sparing effect of clonidine added to ropivacaine for labor epidural analgesia. Anesth Analg 2002; 95:728-34
5. Chassard D, Mathon L, Dailler F, Golfier F, Tournadre JP, Boulétreau P: Extradural clonidine combined with sufentanil and 0.0625% bupivacaine for analgesia in labour. Br J Anaesth 1996; 77:458-62
6. Owen M, Özsaraç Ö, Sahin S, Uçkunkaya N, Kaplan N, Magunaci I: Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia. ANESTHESIOLOGY 2000; 92:361-6
7. D'Angelo R, Dean L, Meister G, Nelson K: Neostigmine combined with bupivacaine, clonidine and sufentanil for spinal labor analgesia. Anesth Analg 2001; 93:1560-4
8. Lauretti GR, de Olivera R, Reis MP, Juliâo M, Pereira N: Study of three different doses of epidural neostigmine coadministered with lidocaine for postoperative analgesia. ANESTHESIOLOGY 1999; 90:1534-38
9. Roelants F, Lavand'homme P: Epidural neostigmine combined with sufentanil provides balanced and selective analgesia in early labor. ANESTHESIOLOGY 2004; 101:439-44
10. Hood D, Mallak K, Eisenach JC. Tong C: Interaction between intrathecal neostigmine and epidural clonidine in human volunteers. ANESTHESIOLOGY 1996; 85:315-25
11. Williams JS, Tong C, Eisenach JC: Neostigmine counteracts spinal clonidine-induced hypotension in sheep. ANESTHESIOLOGY 1993; 78:301-7
12. Hood D, Eisenach JC, Tong C, Tommasi E, Yaksh T: Cardiorespiratory and spinal cord blood flow effects of intrathecal neostigmine methylsulfate, Clonidine and their combination in sheep. ANESTHESIOLOGY 1995; 82:428-35
13. Pertovaara A, Kalmari J: Comparison of the visceral antinociceptive effects of spinally administered MPV-2426 (fadolmidine) and clonidine in the rat. ANESTHESIOLOGY 2003; 98:189-94
14. Shin SW, Eisenach JC: Intrathecal clonidine inhibits response to noxious uterine cervical distension (abstract). ANESTHESIOLOGY 2003; 99:A1212
15. D'Angelo R: Should we administer epidural or spinal clonidine during labor? Reg Anesth Pain Med 2000; 25:3-4
16. Chiari A, Tobin JR, Pan HL, Hood D, Eisenach JC: Sex differences in cholinergic analgesia: I. A supplemental nicotinic mechanism in normal females. ANESTHESIOLOGY 1999; 91:1447-54
17. Roelants F, Rizzo M, Lavand'homme P: The effect of epidural neostigmine combined with ropivacaine and sufentanil of neuraxial analgesia during labor. Anesth Analg 2003; 96:1161-6
18. Kaya F, Sahin S, Owen M, Eisenach JC: Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery. ANESTHESIOLOGY 2004; 100:381-5
19. Nelson KE, D'Angelo R, Foss M, Meister G, Hood D, Eisenach JC: Intrathecal neostigmine and sufentanil for early labor analgesia. ANESTHESIOLOGY 1999; 91:1293-8
20. Eisenach JC, Detweiler D, Tong C, D'Angelo R, Hood D: Cerebrospinal fluid norepinephrine and acetylcholine concentrations during acute pain. Anesth Analg 1996; 82:621-6
21. Lauretti GR, Lima IC: The effects of intrathecal neostigmine on somatic and visceral pain: Improvement by association with a peripheral anticholinergic. Anesth Analg 1996; 82:617-20
22. Cigarini I, Kaba A, Bonnet F, Brohon E, Dutz F, Damas F, Hans P: Epidural clonidine combined with bupivacaine for analgesia in labor. Reg Anesthesia 1995; 20:113-20
23. Chiari A, Lorber C, Eisenach JC, Wildling E, Krenn C, Zavrsky A, Kainz C, Germann P, Klimscha W: Analgesic and hemodynamic effects of intrathecal clonidine as sole analgesic agent during first stage of labor: A dose-response study. ANESTHESIOLOGY 1999; 91:388-96
24. Buggy DJ, MacDowell C: Extradural analgesia with clonidine and fentanyl compared with 0.25% bupivacaine in the first stage of labour. Br J Anaesth 1996; 76:319-21
25. Connelly NR, Mainkar T, El-Mansouri M, Manikantan P, Venkata R, Dunn S, Parker R: Effect of epidural clonidine added to epidural sufentanil for labor pain management. Int J Obstet Anesth 2000; 9:94-8
26. De Kock M, Eisenach J, Tong C, Schmitz AL, Scholtes JL: Analgesic doses of intrathecal but not intravenous clonidine increase acetylcholine in cerebrospinal fluid in humans. Anesth Analg 1997; 84:800-3
27. Naguib M, Yaksh TL: Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with μ and α2 receptor systems. ANESTHESIOLOGY 1994; 80:1338-48
28. Lauretti GR, Reis MP: Subarachnoid neostigmine does not affect blood pressure or heart rate during bupivacaine spinal anesthesia. Reg Anesth 1996; 21:586-91
29. Lyons G, Columb M, Hawthhorne L, Dresner M: Extradural pain relief in labour: Bupivacaine sparing by extradural fentanyl is dose dependent. Br J Anaesth 1997; 78:493-7