Intracerebroventricular infusion of the (pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension

Hypertension

Volumn 65, Issue 2, 2015, Pages 352-361

  Li, Wencheng ^a   Sullivan, Michelle N ^a   Zhang, Sheng ^b   Worker, Caleb J ^a   Xiong, Zhenggang ^b   Speth, Robert C ^c   Feng, Yumei ^a  

^a Department of Ecosystem Science and Sustainability   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

(pro)renin receptor; central nervous system; hypertension

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CAPTOPRIL; DEOXYCORTICOSTERONE ACETATE; LOSARTAN; PRO20; PRORENIN; PRORENIN RECEPTOR; UNCLASSIFIED DRUG; ATP6AP2 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE FRAGMENT; PRO20 PEPTIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RENIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEOXYCORTICOSTERONE-SALT INDUCED HYPERTENSION; DISSOCIATION CONSTANT; DRUG INFUSION; DRUG SPECIFICITY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHALAMUS; KNOCKOUT MOUSE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RECEPTOR BINDING; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BLOOD PRESSURE; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GENETICS; HYPERTENSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; ION TRANSPORT; METABOLISM; NEUROBLASTOMA; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; TOXICITY; TUMOR CELL LINE;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BAROREFLEX; BINDING, COMPETITIVE; BLOOD PRESSURE; CALCIUM; CAPTOPRIL; CELL LINE, TUMOR; DESOXYCORTICOSTERONE ACETATE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYPERTENSION; HYPOTHALAMUS; INFUSIONS, INTRAVENTRICULAR; ION TRANSPORT; LOSARTAN; MICE; MICE, INBRED C57BL; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CELL SURFACE; RENIN; SODIUM CHLORIDE; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84921602193     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04458     Document Type: Article

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