Optimization of nanostructured lipid carriers of lamotrigine for brain delivery: In vitro characterization and in vivo efficacy in epilepsy

Expert Opinion on Drug Delivery

Volumn 12, Issue 2, 2015, Pages 181-194

  Alam, Tausif ^a   Pandit, Jayamanti ^a   Vohora, Divya ^a   Aqil, Mohd ^a   Ali, Asgar ^a   Sultana, Yasmin ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Brain delivery; Epilepsy; Intranasal delivery; Lamotrigine; Nanostructured lipid carriers

Indexed keywords

DRUG CARRIER; GLUTATHIONE; LAMOTRIGINE; NANOSTRUCTURED LIPID CARRIER; SOLID LIPID NANOPARTICLE; SURFACTANT; UNCLASSIFIED DRUG; LIPID; NANOMATERIAL; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIFFUSION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; ENTRAPMENT EFFICIENCY; EPILEPSY; EX VIVO STUDY; FICKIAN DIFFUSION; GAMMA SCINTIGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LATENT PERIOD; MALE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; POLYDISPERSITY INDEX; RAT; RESPONSE SURFACE METHOD; ZETA POTENTIAL; ANIMAL; CHEMISTRY; INTRANASAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; METABOLISM; WISTAR RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EPILEPSY; IN VITRO TECHNIQUES; LIPIDS; MALE; NANOSTRUCTURES; PARTICLE SIZE; RATS; RATS, WISTAR; TRIAZINES;

EID: 84921530572     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.945416     Document Type: Article

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