GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1

European Journal of Medicinal Chemistry

Volumn 91, Issue , 2015, Pages 132-144

  Persico, Marco ^a   Petrella, Lella ^b   Orteca, Nausicaa ^a   Di Dato, Antonio ^a   Mariani, Marisa ^c   Andreoli, Mirko ^c   De Donato, Marta ^d   Scambia, Giovanni ^d   Novellino, Ettore ^a   Ferlini, Cristiano ^c   Fattorusso, Caterina ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Jean Paul IInd Research Foundation   (Italy)

^c DANBURY HOSPITAL   (United States)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANYLATE BINDING PROTEIN 1; PACLITAXEL; PROTEIN KINASE PIM 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GBP1 PROTEIN, HUMAN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; PIM1 PROTEIN, HUMAN; PROTEIN BINDING; RECOMBINANT PROTEIN; TUMOR PROTEIN;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BETA SHEET; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTALLIZATION; HYDROGEN BOND; OLIGOMERIZATION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; DRUG RESISTANCE; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING SITES; DRUG RESISTANCE, NEOPLASM; ESCHERICHIA COLI; GENE EXPRESSION; GTP-BINDING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PACLITAXEL; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-PIM-1; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 84921521348     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.093     Document Type: Article

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