Mucoadhesive polymers-based film as a carrier system for sublingual delivery of glutathione

Journal of Pharmacy and Pharmacology

Volumn 67, Issue 1, 2015, Pages 26-34

  Chen, Guanyu ^a   Bunt, Craig ^b   Wen, Jingyuan ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b LINCOLN UNIVERSITY   (New Zealand)

Author keywords

films; mucoadhesive; permeation enhancement; sublingual delivery; sustained release

Indexed keywords

BETA GLUCAN; CARBOMER; CHITOSAN; DRUG CARRIER; GLUTATHIONE; HYDROXYLPROPYL METHYLCELLULOSE; METHYLCELLULOSE; POLYVINYL ALCOHOL; POVIDONE; UNCLASSIFIED DRUG; DELAYED RELEASE FORMULATION; POLYMER;

ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG PENETRATION; DRUG RETENTION; DRUG SOLUBILITY; DRUG SYNTHESIS; EX VIVO STUDY; IN VITRO STUDY; MOUTH MUCOSA; MUCOADHESION; MUCOADHESIVENESS; NONHUMAN; PHYSICAL PARAMETERS; SURFACE PH; SUSTAINED DRUG RELEASE; THICKNESS; WEIGHT UNIFORMITY; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG RELEASE; MEDICINAL CHEMISTRY; METABOLISM; PH; PIG; PROCEDURES; SUBLINGUAL DRUG ADMINISTRATION;

ADMINISTRATION, SUBLINGUAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; GLUTATHIONE; HYDROGEN-ION CONCENTRATION; MOUTH MUCOSA; POLYMERS; SWINE;

EID: 84921499658     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12313     Document Type: Article

References (41)

1. Pompella A, et al. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 2003; 66: 1499-1503.
2. Michael CR, et al. A mathematical model of glutathione metabolism. Theor Biol Med Model 2009; 1: 115-119.
3. Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol 1992; 43: 667-669.
4. Shojaie AH,. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci 1998; 1: 15-30.
5. John DN, et al. Pharmacokinetics and pharmacodynamics of verapamil following sublingual and oral administration to healthy volunteers. Br J Clin Pharmacol 1992; 33: 623-627.
6. Walton RP,. Absorption of drugs through the oral mucosa. III Fat-water solubility coefficient of alkaloids. Proc Soc Exp Bio Med 1935; 32: 1488-1492.
7. Salamat MN,. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005; 57: 1666-1691.
8. Sangsuwan J, et al. Effect of chitosan/methyl cellulose films on microbial and quality characteristics of fresh-cut cantaloupe and pineapple. Postharvest Biol Technol 2008; 49: 403-410.
9. Hagenmaier RD, Philip ES,. Moisture permeability of edible films made with fatty acid and hydroxypropyl methyl cellulose. J Agric Food Chem 1990; 38: 1799-1803.
10. Chun MK, et al. Preparation of buccal patch composed of carbopol, poloxamer and hydroxypropyl methylcellulose. Arch Pharm Res 2003; 26: 973-978.
11. Lafargue D, et al. Film-forming properties of a modified starch/κ-carrageenan mixture in relation to its rheological behaviour. Carbohydr Poly 2007; 70: 101-111.
12. Soares RMD, et al. Thermal degradation of biodegradable edible films based on xanthan and starches from different sources. Polym Degrad Staby 2005; 90: 449-454.
13. Aramaki K,. Protection of iron corrosion by ultrathin two-dimensional polymer films of an alkanethiol monolayer modified with alkylethoxysilanes. Corros Sci 1999; 41: 1715-1730.
14. Shu XZ, et al. Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release. Int J Pharm 2001; 212: 19-28.
15. Kast CE, Schnurch AB,. Thiolated polymers thiomers: development and in vitro evaluation of chitosan thioglycolic acid conjugates. Biomaterials 2001; 22: 2345-2352.
16. Salamat-Miller N, et al. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005; 57: 1666-1691.
17. Wester RC, et al. Pharmacokinetics and bioavailability of intravenous and topical nitroglycerin in the rhesus monkey: estimate of percutaneous first-pass metabolism. J Pharm Sci 1983; 72: 745-748.
18. Remuñán-Lõpez C, et al. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Release 1998; 55: 143-152.
19. Wen J, et al. Development of water-in-oil microemulsions with the potential of prolonged release for oral delivery of L-glutathione. Pharm Dev Technol 2013; 18: 1424-1429.
20. Wong CF, et al. Formulation and evaluation of controlled release Eudragit buccal patches. Int J Pharm 1999; 178: 11-22.
21. Garnpimol CR, et al. Moist heat treatment on physicochemical change of chitosan salt films. Int J Pharm 2002; 232: 11-22.
22. Mona S, et al. Formulation and characterization of mucoadhesive buccal films of glipizide. Indian J Pharm Sci 2008; 70: 43-48. doi: 10.4103/0250-474X.40330.
23. Nafee NA, et al. Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing. Int J Pharm 2003; 264: 1-14.
24. Peh KK, et al. Polymeric films as vehicle for buccal delivery: swelling, mechanical, and bioadhesive properties. J Pharm Pharm Sci 1999; 2: 53-61.
25. Eouani C, et al. In-vitro comparative study of buccal mucoadhesive performance of different polymeric films. Eur J Pharm Biopharm 2001; 52: 45-55.
26. Semalty A, et al. Design and evaluation of mucoadhesive buccal films of diltiazem hydrochloride. Indian J Pharm Sci 2005; 67: 548-552.
27. Arakawa Y, et al. Effect of low-molecular-weight β-cyclodextrin polymer on release of drugs from mucoadhesive buccal film dosage forms. Biol Pharm Bull 2005; 28: 1679-1683.
28. Mashru RC, et al. Development and evaluation of fast dissolving film of salbutamol sulphate. Drug Dev Ind Pharm 2005; 31: 25-34.
29. Junginger HE, et al. Recent advances in buccal drug delivery and absorption in vitro and in vivo studies. J Control Release 1999; 62: 149-159.
30. Higuchi T,. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963; 52: 1145-1149.
31. Korsmeyer RW, et al. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 1983; 15: 25-35.
32. Surya NR, et al. Formulation and evaluation of buccal patches for delivery of atenolol. AAPS PharmSciTech 2010; 11: 1038-1044.
33. Ofori-Kwakye K, Fell JT,. Biphasic drug release: the permeability of films containing pectin, chitosan and HPMC. Int J Pharm 2001; 226: 139-145.
34. Patel VM, et al. Design and characterization of chitosan-containing mucoadhesive buccal patches of propranolol hydrochloride. Acta Pharm 2007; 57: 61-72.
35. Kavanagh N, et al. Swelling and erosion properties of hydroxypropylmethylcellulose (Hypromellose) matrices-influence of agitation rate and dissolution medium composition. Int J Pharm 2004; 279: 141-152.
36. Conti S, et al. Matrices containing NaCMC and HPMC: dissolution performance characterization. Int J Pharm 2007; 333: 136-142.
37. Yoo JW, et al. The physicodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. Int J Pharm 2006; 309: 139-145.
38. Kaur IP, Smitha R,. Penetration enhancers and ocular bioadhesives: two new avenues for ophthalmic drug delivery. Drug Dev Ind Pharm 2002; 28: 353-369.
39. Veuillez F, et al. Factors and strategies for improving buccal absorption of peptides. Eur J Pharm Biopharm 2001; 51: 93-109.
40. Hao J, Paul WS,. Buccal delivery systems. Drug Dev Ind Pharm 2003; 29: 821-832.
41. Sandri G, et al. Assessment of chitosan derivatives as buccal and vaginal penetration enhancers. Eur J Pharm Sci 2004; 21: 351-359.