Development of water-in-oil microemulsions with the potential of prolonged release for oral delivery of L-glutathione

Pharmaceutical Development and Technology

Volumn 18, Issue 6, 2013, Pages 1424-1429

  Wen, Jingyuan ^a   Du, Yun ^a   Li, Danhui ^a   Alany, Raid ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

HPLC; L glutathione; Microemulsion; Oral delivery; Release kinetics; Rheological evaluation

Indexed keywords

GLUTATHIONE; OIL; WATER; DELAYED RELEASE FORMULATION; EMULSION; SURFACTANT;

ARTICLE; COLLOID; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; FLOW KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE EPITHELIUM; LIQUID CRYSTAL; MICROEMULSION; MORPHOLOGY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; CHEMISTRY; DELAYED RELEASE FORMULATION; EMULSION; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PERMEABILITY; PROCEDURES; VISCOSITY;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EMULSIONS; GLUTATHIONE; LIQUID CRYSTALS; OILS; PERMEABILITY; RHEOLOGY; SURFACE-ACTIVE AGENTS; VISCOSITY; WATER;

EID: 84883380793     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2012.734518     Document Type: Article

References (14)

1. Yilmaz O, Keser S, Tutzcu M, Guvenc M, Cetintas B, Irtegun S et al. A practical HPLC method to measure reduced (GSH) and oxidized (GSSG) glutathione concentrations in animal tissues. J Anim Vet Adv 2009;8:343-347
2. Struzynska L, Chalimoniuk M, Sulkowski G. The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity. Toxicology 2005;212:185-194 (Pubitemid 40984024)
3. Sechi G, Deledda MG, Bua G, Satta WM, Deiana GA, Pes GM et al. Reduced intravenous glutathione in the treatment of early Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 1996;20:1159-1170 (Pubitemid 26387426)
4. Leone-Bay A, Paton DR, Weidner JJ. The development of delivery agents that facilitate the oral absorption of macromolecular drugs. Med Res Rev 2000;20:169-186 (Pubitemid 30134324)
5. Allenmann E, Lerous J, Gurny R. Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics. Adv Drug Deliv Rev 1998;34:171-189 (Pubitemid 28535111)
6. Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption:physical and biopharmaceutical aspects. Pharm Res 1995;12:1561-1572 (Pubitemid 26005509)
7. Aulton ME. (2002). Pharmaceutics the science of dosage form design. Edinburgh: Churchill Living stone, 334-350
8. Graf A, Rades T, Hook SM. Oral insulin delivery using nanoparticles based on microemulsions with different structuretypes: optimisation and in vivo evaluation. Eur J Pharm Sci 2009;37:53-61
9. Cheng MB, Wang JC, Li YH, Liu XY, Zhang X, Chen DW et al. Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme. J Control Release 2008;129:41-48
10. Cilek A, Celebi N, Tirnaksiz F. Lecithin-based microemulsion of a peptide for oral administration:preparation, characterization, and physical stability of the formulation. Drug Deliv 2006;13:19-24 (Pubitemid 43087616)
11. Raggi MA, Mandrioli R, Casamenti G, Musiani D, Marini M. HPLC determination of glutathione and other thiols in human mononuclear blood cells. Biomed Chromatogr 1998;12:262-266 (Pubitemid 28457184)
12. Alany RG, Tucker IG, Davies NM, Rades T. Characterizing colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems. Drug Dev Ind Pharm 2001;27:31-38 (Pubitemid 32195358)
13. Chan J, Maghraby GM, Craig JP, Alany RG. Phase transition waterin- oil microemulsions as ocular drug delivery systems:in vitro and in vivo evaluation. Int J Pharm 2007;328:65-71 (Pubitemid 44827562)
14. Martin A, Bustamante P, Chun AHC. (1993). Physical pharmacy. Maryland:Lippincott Williams and Wilkins, 564-565