Pharmacokinetic Drug-Drug Interaction of Calcium Channel Blockers With Cyclosporine in Hematopoietic Stem Cell Transplant Children

Annals of Pharmacotherapy

Volumn 48, Issue 12, 2014, Pages 1580-1584

  Bernard, Elodie ^a   Goutelle, Sylvain ^b   Bertrand, Yves ^a   Bleyzac, Nathalie ^a  

^a Institut d'Hematologie et d'Oncologie Pediatrique   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

bone marrow transplantation; calcium channel blockers; cyclosporine; drug interactions; pediatrics

Indexed keywords

AMLODIPINE; CYCLOSPORIN; CYTOCHROME P450 3A4; LACIDIPINE; NICARDIPINE; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIHYPERTENSIVE THERAPY; ARTICLE; CHILD; DRUG BLOOD LEVEL; FEMALE; HUMAN; HYPERTENSION; INFANT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; CHEMICALLY INDUCED; DRUG INTERACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; PRESCHOOL CHILD;

ADOLESCENT; AMLODIPINE; CALCIUM CHANNEL BLOCKERS; CHILD; CHILD, PRESCHOOL; CYCLOSPORINE; DIHYDROPYRIDINES; DRUG INTERACTIONS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; HYPERTENSION; IMMUNOSUPPRESSIVE AGENTS; INFANT; MALE; NICARDIPINE; RETROSPECTIVE STUDIES;

EID: 84921495582     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028014550644     Document Type: Article

References (39)

1. Robert N,Wong GW,Wright JM.Effect of cyclosporine on blood pressure.Cochrane Database Syst Rev. 2010; (20): 1-50
2. Hoorn EJ,Walsh SB,McCormick JA,Zietse R,Unwin RJ,Ellison DH.Pathogenesis of calcineurin inhibitor–induced hypertension.J Nephrol. 2012;25:269-275
3. Rodicio JL.Calcium antagonists and renal protection from cyclosporine nephrotoxicity: long-term trial in renal transplantation patients.J Cardiovasc Pharmacol. 2000;35:S7-S11
4. Luft FC.How calcineurin inhibitors cause hypertension.Nephrol Dial Transplant. 2012;27:473-475
5. Pfeilschifter J,Rüegg UT.Cyclosporin A augments angiotensin II-stimulated rise in intracellular free calcium in vascular smooth muscle cells.Biochem J. 1987;248:883-887
6. van der Schaaf MR,Hené RJ,Floor M,Blankestijn PJ,Koomans HA.Hypertension after renal transplantation: calcium channel or converting enzyme blockade?.Hypertension. 1995;25:77-81
7. Khattak S,Rogan JW,Saunders EF,Theis JG,Arbus GS,Koren G.Efficacy of amlodipine in pediatric bone marrow transplant patients.Clin Pediatr. 1998;37:31-35
8. Rogan JW,Lyszkiewicz DA,Blowey D,Khattak S,Arbus GS,Koren G.A randomized prospective crossover trial of amlodipine in pediatric hypertension.Pediatr Nephrol. 2000;14:1083-1087
9. Flynn JT.Efficacy and safety of prolonged amlodipine treatment in hypertensive children.Pediatr Nephrol. 2005;20:631-635
10. Andersen J,Groshong T,Tobias JD.Preliminary experience with amlodipine in the pediatric population.Am J Ther. 2006;13:198-204
11. Guengerich FP,Brian WR,Iwasaki M,Sari MA,Baarnhielm C,Berntsson P.Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.J Med Chem. 1991;34:1338-1344
12. Katoh M,Nakajima M,Shimada N,Yamazaki H,Yokoi T.Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions.Eur J Clin Pharmacol. 2000;55:843-852
13. Xia Z,Wang M,Zou S,Chen R.Different effects of dihydropyridine calcium channel antagonists on CYP3A4 enzyme of human liver microsomes.Eur J Drug Metab Pharmacokinet. 2012;37:211-216
14. Hebert MF.Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery.Adv Drug Deliv Rev. 1997;27:201-214
15. Huet E,Morand K,Blanchet B,Astier A,Hulin A.Evaluation of the new heterogeneous ACMIA immunoassay for the determination of whole-blood cyclosporine concentrations in bone marrow, kidney, heart, and liver transplant recipients.Transplant Proc. 2004;36:1317-1320
16. Bleyzac N.The use of pharmacokinetic models in paediatric onco-haematology: effects on clinical outcome through the examples of busulfan and cyclosporine.Fundam Clin Pharmacol. 2008;22:605-608
17. Martin P,Bleyzac N,Souillet G, et al.Relationship between cyclosporine trough blood concentrations and severity of acute graft-versus-host-disease after paediatric stem cell transplantation from matched-sibling or unrelated donors.Bone Marrow Transplant. 2003;32:777-784
18. Martin P,Bleyzac N,Souillet G, et al.Clinical and pharmacological risk factors for acute graft-versus-host disease after paediatric stem cell transplantation from matched-sibling or unrelated donors.Bone Marrow Trans-plant. 2003;32:881-887
19. Willemze AJ,Press RR,Lankester AC,Egeler RM,den Hartigh J,Vossen JM.CsA exposure is associated with acute GVHD and relapse in children after SCT.Bone Marrow Transplant. 2010;45:1056-1061
20. Gérard C,Bleyzac N,Girard P,Freyer G,Bertrand Y,Tod M.Links between cyclosporin exposure in tissues and graft-versus-host disease in pediatric bone marrow transplantation: analysis by a PBPK model.Pharm Res. 2011;28:531-539
21. Ozbay A,Karamperis N,Jørgensen KA.A review of the immunosuppressive activity of cyclosporine metabolites: new insights into an old issue.Curr Clin Pharmacol. 2007;2:244-248
22. Salem F,Rostami-Hodjegan A,Johnson TN.Do children have the same vulnerability to metabolic drug–drug interactions as adults? A critical analysis of the literature.J Clin Pharmacol. 2013;53:559-566
23. Salem F,Johnson TN,Barter ZE,Leeder JS,Rostami-Hodjegan A.Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.J Clin Phar-macol. 2013;53:857-865
24. Toupance O,Lavaud S,Canivet E,Bernaud C,Hotton JM,Chanard J.Antihypertensive effect of amlodipine and lack of interference with cyclosporine metabolism in renal transplant recipients.Hypertension. 1994;24:297-300
25. Pfammatter JP,Clericetti-Affolter C,Truttmann AC,Busch K,Laux-End R,Bianchetti MG.Amlodipine once-daily in systemic hypertension.Eur J Pediatr. 1998;157:618-621
26. von Vigier RO,Franscini LM,Bianda ND, et al.Antihypertensive efficacy of amlodipine in children with chronic kidney diseases.J Hum Hypertens. 2001;15:387-391
27. Chanard J,Toupance O,Lavaud S,Hurault de,Ligny B,Bernaud C,Moulin B.Amlodipine reduces cyclosporin-induced hyperuricaemia in hypertensive renal transplant recipients.Nephrol Dial Transplant. 2003;18:2147-2153
28. Pesavento TE,Jones PA,Julian BA,Curtis JJ.Amlodipine increases cyclosporine levels in hypertensive renal transplant patients.J Am Soc Nephrol. 1996;7:831-835
29. Cai J,Huang Z,Yang G, et al.Comparing antihypertensive effect and plasma cyclosporin concentration between amlodipine and valsartan regimens in hypertensive renal transplant patients receiving ciclosporin therapy.Am J Cardiovasc Drugs. 2011;11:401-409
30. Todd P,Garioch JJ,Rademaker M,Thomson J.Nicardipine interacts with cyclosporin.Br J Dermatol. 1989;121:820
31. Bagnis C,Deray G.Calcium inhibitors in the management of hypertensive patients on cyclosporine.Arch Mal Coeur Vaiss. 1998;91:411-414
32. Guan D,Wang R,Lu J,Wang M,Xu C.Effects of nicardipine on blood cyclosporine levels in renal transplant patients.Transplant Proc. 1996;28:1311-1312
33. Katoh M,Nakajima M,Yamasaki H,Yokoi T.Inhibitory potencies of 1,4 dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.Pharm Res. 2000;10:1189-1197
34. Ruggenenti P,Perico N,Mosconi L, et al.Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion.Kidney Int. 1993;43:706-711
35. Kuypers DR,Neumayer HH,Fritsche L, et al.Calcium channel blockade and preservation of renal graft function in cyclosporine-treated recipients: a prospective randomized placebo-controlled 2-year study.Transplantation. 2004;78:1204-1211
36. Gertz M,Cartwright CM,Hobbs MJ, et al.Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential.Pharm Res. 2013;30:761-780
37. Madsen JK,Jensen JD,Jensen LW,Pedersen EB.Pharmacokinetic interaction between cyclosporine and the dihydropyridine calcium antagonist felodipine.Eur J Clin Pharmacol. 1996;50:203-208
38. Gertz M,Houston JB,Galetin A.Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction.Drug Metab Dispos. 2011;39:1633-1642
39. Dorababu M,Nishimura A,Prabha T, et al.Effect of cyclosporine on drug transport and pharmacokinetics of nifedipine.Biomed Pharmacother. 2009;63:697-702