Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: Comparison with the effects on CYP3A4

Pharmaceutical Research

Volumn 17, Issue 10, 2000, Pages 1189-1197

  Katoh, Miki ^a   Nakajima, Miki ^a   Yamazaki, Hiroshi ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

1,4 Dihydropyridine calcium antagonists; Cytochrome P450 3A4; Inhibition; P glycoprotein

Indexed keywords

1,4 DIHYDROPYRIDINE; AMLODIPINE; ARANIDIPINE; BENIDIPINE; CALCIUM ANTAGONIST; CILNIDIPINE; CYTOCHROME P450 3A4; DAUNORUBICIN; DIGOXIN; EFONIDIPINE; FELODIPINE; GLYCOPROTEIN P; MANIDIPINE; MEPIRODIPINE; NICARDIPINE; NIFEDIPINE; NILVADIPINE; NISOLDIPINE; NITRENDIPINE;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG TRANSPORT; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSCYTOSIS;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM CHANNEL BLOCKERS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DAUNORUBICIN; DIGOXIN; DIHYDROPYRIDINES; HUMANS; MIXED FUNCTION OXYGENASES; P-GLYCOPROTEIN; SUBSTRATE SPECIFICITY; TRANSFECTION; TRITIUM;

EID: 0033636618     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007568811691     Document Type: Article

References (24)

1. Biochemistry of multidrug resistance mediated by the multidrug transporter
2. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
3. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
4. P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies
5. Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: Prediction of in vivo drug-drug interactions
6. Pharmacology of drugs that alter multidrug resistance in cancer
7. Restoration of doxorubicin responsiveness in doxorubicin-resistant P 388 murine leukaemia cells
8. P-glycoprotein-mediated transcellular transport of MDR-reversing agents
9. Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein
10. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone
11. 1)
12. Protein measurement with the Folin phenol reagent
13. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailavility of cyclosporine
14. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cystein protease inhibitor
15. Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption - Theoretical approach
16. Effects of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein
17. Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubiciniand vinblastine via human P-glycoprotein
18. Apotosis and necrosis: Mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line
19. Interaction of docetaxel ('Taxotere') with human P-glycoprotein
20. Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs
21. Interaction between digoxin and the calcium antagonists nicardipine and tiapamil
22. Non-interaction between nifedipine and digoxin
23. Molecular modeling of cytochrome P450 3A4
24. The CYP2 family: Models, mutants and interactions