How calcineurin inhibitors cause hypertension

Nephrology Dialysis Transplantation

Volumn 27, Issue 2, 2012, Pages 473-475

  Luft, Friedrich C ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

calcineurin inhibitors; hypertension; sodium chloride cotransporter; tacrolimus

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN; FUROSEMIDE; HYDROCHLOROTHIAZIDE; PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; SODIUM CHLORIDE COTRANSPORTER; TACROLIMUS;

DISEASE ASSOCIATION; DRUG EFFICACY; DRUG INDUCED DISEASE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HYPERTENSION; NEPHROTOXICITY; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PSEUDOHYPOALDOSTERONISM; PSEUDOHYPOALDOSTERONISM TYPE II;

BLOOD PRESSURE; CALCINEURIN; CYCLOSPORINE; HUMANS; HYPERTENSION; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SODIUM CHLORIDE SYMPORTERS; TACROLIMUS;

EID: 84856829555     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr679     Document Type: Note

References (5)

1. Hoorn EJ, Nelson JH, McCormick JA et al. The WNK kinase network regulating sodium, potassium, and blood pressure. J Am Soc Nephrol 2011; 22: 605-614
2. Mercier-Zuber A, O'Shaughnessy KM. Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters. Curr Opin Nephrol Hypertens 2011; 20: 534-540
3. Hoorn EJ, Walsh SB, McCormick JA et al. The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension. Nat Med 2011; 17: 1304-1309
4. Cui Y, Huang Q, Auman JT et al. Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity. Toxicol Sci 2011; 124: 23-34
5. Hu DC, Burtner C, Hong A et al. Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome. Am J Med Sci 2006; 331: 105-109