Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy

American Journal of Physiology - Cell Physiology

Volumn 308, Issue 2, 2015, Pages C155-C163

  Tigchelaar, Wardit ^a   Yu, Hongjuan ^a,b   De Jong, Anne Margreet ^a   Van Gilst, Wiek H ^a   Van Der Harst, Pim ^a   Daan Westenbrink, B ^a   De Boer, Rudolf A ^a   Silljé, Herman H W ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Cardiomyocytes; Hypertrophy; Mitochondria; Mitochondrial respiration; ROS

Indexed keywords

ENDONUCLEASE; EXONUCLEASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; PROTEIN S6; REACTIVE OXYGEN METABOLITE; ADENOSINE TRIPHOSPHATE;

ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; CELL SIZE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; HEART MUSCLE CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TARGETING SIGNAL; NEWBORN; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RAT; WESTERN BLOTTING; ANIMAL; CELL RESPIRATION; GENETICS; HYPERTROPHY; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGY; RADIATION RESPONSE; SIGNAL TRANSDUCTION;

PHOS; RATTUS; VASCONCELLEA CANDICANS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL RESPIRATION; DNA, MITOCHONDRIAL; ENDONUCLEASES; EXONUCLEASES; GENE EXPRESSION; HYPERTROPHY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84921491251     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00227.2014     Document Type: Article

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