IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa

Journal of Immunology

Volumn 194, Issue 3, 2015, Pages 1334-1346

  Yuan, Xiaomei ^a   Dee, Michael J ^a   Altman, Norman H ^a   Malek, Thomas R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR BETA; TRANSCRIPTOME; ALPHA E INTEGRINS; ALPHA INTEGRIN; LEUKOCYTE ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL METABOLISM; CELL MIGRATION; CELLULAR DISTRIBUTION; COLITIS; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; INTESTINE MUCOSA; LYMPHOCYTE COUNT; MALE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; ANIMAL; CELL MOTION; CLUSTER ANALYSIS; DENDRITIC CELL; GENE EXPRESSION PROFILING; GENETICS; HOMEOSTASIS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; PHENOTYPE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; CELL MOVEMENT; CLUSTER ANALYSIS; COLITIS; DENDRITIC CELLS; FEMALE; GENE EXPRESSION PROFILING; HOMEOSTASIS; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; INTEGRIN ALPHA CHAINS; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; INTESTINAL MUCOSA; MALE; MICE; MICE, TRANSGENIC; PHENOTYPE; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84921484812     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400955     Document Type: Article

References (43)

1. Barnes, M. J., and F. Powrie. 2009. Regulatory T cells reinforce intestinal homeostasis. Immunity 31: 401-411.
2. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
3. Li, M. O., Y. Y. Wan, and R. A. Flavell. 2007. T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26: 579-591.
4. Rubtsov, Y. P., J. P. Rasmussen, E. Y. Chi, J. Fontenot, L. Castelli, X. Ye, P. Treuting, L. Siewe, A. Roers, W. R. Henderson, Jr., et al. 2008. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28: 546-558.
5. Collison, L. W., C. J. Workman, T. T. Kuo, K. Boyd, Y. Wang, K. M. Vignali, R. Cross, D. Sehy, R. S. Blumberg, and D. A. Vignali. 2007. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450: 566-569.
6. + T cells. J. Exp. Med. 183: 2669-2674.
7. Izcue, A., J. L. Coombes, and F. Powrie. 2009. Regulatory lymphocytes and intestinal inflammation. Annu. Rev. Immunol. 27: 313-338.
8. Kullberg, M. C., J. M. Ward, P. L. Gorelick, P. Caspar, S. Hieny, A. Cheever, D. Jankovic, and A. Sher. 1998. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12-and g interferon-dependent mechanism. Infect. Immun. 66: 5157-5166.
9. 7 integrin. Nature 372: 190-193.
10. + Treg and control of Leishmania major infection. J. Immunol. 174: 5444-5455.
11. Annacker, O., J. L. Coombes, V. Malmstrom, H. H. Uhlig, T. Bourne, B. Johansson-Lindbom, W. W. Agace, C. M. Parker, and F. Powrie. 2005. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J. Exp. Med. 202: 1051-1061.
12. E (CD103)-deficient mice. J. Immunol. 162: 6641-6649.
13. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
14. Wellcome Trust Case Control Consortium. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
15. Todd, J. A. 2010. Etiology of type 1 diabetes. Immunity 32: 457-467.
16. Yu, A., L. Zhu, N. H. Altman, and T. R. Malek. 2009. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 30: 204-217.
17. + terminally differentiated T regulatory cells. J. Immunol. 189: 1780-1791.
18. Wan, Y. Y., and R. A. Flavell. 2005. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 102: 5126-5131.
19. Kallies, A., E. D. Hawkins, G. T. Belz, D. Metcalf, M. Hommel, L. M. Corcoran, P. D. Hodgkin, and S. L. Nutt. 2006. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat. Immunol. 7: 466-474.
20. - regulatory T cells. Proc. Natl. Acad. Sci. USA 99: 13031-13036.
21. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16: 311-323.
22. + regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis. Eur. J. Immunol. 33: 2419-2428.
23. + dendritic cells. Immunol. Rev. 234: 268-281.
24. + T cells. Mucosal Immunol. 1: 38-48.
25. + regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J. Exp. Med. 204: 1757-1764.
26. Sun, C. M., J. A. Hall, R. B. Blank, N. Bouladoux, M. Oukka, J. R. Mora, and Y. Belkaid. 2007. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204: 1775-1785.
27. Benson, M. J., K. Pino-Lagos, M. Rosemblatt, and R. J. Noelle. 2007. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204: 1765-1774.
28. + dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 205: 2139-2149.
29. Feuerer, M., J. A. Hill, K. Kretschmer, H. von Boehmer, D. Mathis, and C. Benoist. 2010. Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc. Natl. Acad. Sci. USA 107: 5919-5924.
30. -/- mice: roles for both IL-2 and IL-15 in CD8aa IEL development. J. Immunol. 163: 5906-5912.
31. Laurence, A., C. M. Tato, T. S. Davidson, Y. Kanno, Z. Chen, Z. Yao, R. B. Blank, F. Meylan, R. Siegel, L. Hennighausen, E. M. Shevach, and J. O'Shea 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26: 371-381.
32. Yang, X. P., K. Ghoreschi, S. M. Steward-Tharp, J. Rodriguez-Canales, J. Zhu, J. R. Grainger, K. Hirahara, H. W. Sun, L. Wei, G. Vahedi, et al. 2011. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12: 247-254.
33. Johansson-Lindbom, B., M. Svensson, M. A. Wurbel, B. Malissen, G. Marquez, and W. Agace. 2003. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J. Exp. Med. 198: 963-969.
34. Li, M. O., S. Sanjabi, and R. A. Flavell. 2006. Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25: 455-471.
35. Marie, J. C., D. Liggitt, and A. Y. Rudensky. 2006. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 25: 441-454.
36. Zhang, N., and M. J. Bevan. 2013. Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention. Immunity 39: 687-696.
37. Casey, K. A., K. A. Fraser, J. M. Schenkel, A. Moran, M. C. Abt, L. K. Beura, P. J. Lucas, D. Artis, E. J. Wherry, K. Hogquist, et al. 2012. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J. Immunol. 188: 4866-4875.
38. + T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J. Exp. Med. 201: 1647-1657.
39. Kamanaka, M., S. T. Kim, Y. Y. Wan, F. S. Sutterwala, M. Lara-Tejero, J. E. Galan, E. Harhaj, and R. A. Flavell. 2006. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 25: 941-952.
40. - precursor cells in the absence of interleukin 10. Nat. Immunol. 8: 931-941.
41. Hill, D. A., and D. Artis. 2010. Intestinal bacteria and the regulation of immune cell homeostasis. Annu. Rev. Immunol. 28: 623-667.
42. H17 cells occurs in the small intestine. Nature 475: 514-518.
43. + T central-memory cell survival but not T effector-memory cell development. J. Immunol. 187: 5170-5182.