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Volumn 17, Issue 2, 2015, Pages 269-287

An essential role for phosphatidylinositol 3-kinase in the inhibition of phagosomal maturation, intracellular survival and virulence in Candida glabrata

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; CARBOXYPEPTIDASE C; FUNGAL PROTEIN; HYDROLASE; PEPTIDES AND PROTEINS; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CGVPS34; PROTEIN EPA1; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE VPS15;

EID: 84921467470     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12364     Document Type: Article
Times cited : (20)

References (37)
  • 1
    • 84866531920 scopus 로고    scopus 로고
    • Vps34p is required for the decline of extracellular fructose-1,6-bisphosphatase in the vacuole import and degradation pathway
    • Alibhoy, A.A., Giardina, B.J., Dunton, D.D., and Chiang, H.L. (2012) Vps34p is required for the decline of extracellular fructose-1, 6-bisphosphatase in the vacuole import and degradation pathway. J Biol Chem 287: 33080-33093.
    • (2012) J Biol Chem , vol.287 , pp. 33080-33093
    • Alibhoy, A.A.1    Giardina, B.J.2    Dunton, D.D.3    Chiang, H.L.4
  • 2
    • 84894261120 scopus 로고    scopus 로고
    • GPI (glycosylphosphatidylinositol)-linked aspartyl proteases regulate vacuole homoeostasis in Candida glabrata
    • Bairwa, G., Rasheed, M., Taigwal, R., Sahoo, R., and Kaur, R. (2014) GPI (glycosylphosphatidylinositol)-linked aspartyl proteases regulate vacuole homoeostasis in Candida glabrata. Biochem J 458: 323-334.
    • (2014) Biochem J , vol.458 , pp. 323-334
    • Bairwa, G.1    Rasheed, M.2    Taigwal, R.3    Sahoo, R.4    Kaur, R.5
  • 3
    • 0033709349 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase of Candida albicans influences adhesion, filamentous growth and virulence
    • Bruckmann, A., Künkel, W., Härtl, A., Wetzker, R., and Eck, R. (2000) A phosphatidylinositol 3-kinase of Candida albicans influences adhesion, filamentous growth and virulence. Microbiology 146: 2755-2764.
    • (2000) Microbiology , vol.146 , pp. 2755-2764
    • Bruckmann, A.1    Künkel, W.2    Härtl, A.3    Wetzker, R.4    Eck, R.5
  • 4
    • 84876324053 scopus 로고    scopus 로고
    • Two unlike cousins: Candida albicans and C.glabrata infection strategies
    • Brünke, S., and Hübe, B. (2013) Two unlike cousins: Candida albicans and C.glabrata infection strategies. Cell Microbiol 15: 701-708.
    • (2013) Cell Microbiol , vol.15 , pp. 701-708
    • Brünke, S.1    Hübe, B.2
  • 5
    • 0033597797 scopus 로고    scopus 로고
    • An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells
    • Cormack, B.P., Ghori, N., and Falkow, S. (1999) An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Science 285: 578-582.
    • (1999) Science , vol.285 , pp. 578-582
    • Cormack, B.P.1    Ghori, N.2    Falkow, S.3
  • 7
    • 0033790751 scopus 로고    scopus 로고
    • Subversion of a young phagosome: the survival strategies of intracellular pathogens
    • Duclos, S., and Desjardins, M. (2000) Subversion of a young phagosome: the survival strategies of intracellular pathogens. Cell Microbiol 2: 365-377.
    • (2000) Cell Microbiol , vol.2 , pp. 365-377
    • Duclos, S.1    Desjardins, M.2
  • 8
    • 0027243781 scopus 로고
    • Histoplasma capsulatum modulates the acidification of phagolysosomes
    • Eissenberg, L.G., Goldman, W.E., and Schlesinger, P.H. (1993) Histoplasma capsulatum modulates the acidification of phagolysosomes. J Exp Med 177: 1605-1611.
    • (1993) J Exp Med , vol.177 , pp. 1605-1611
    • Eissenberg, L.G.1    Goldman, W.E.2    Schlesinger, P.H.3
  • 9
    • 84864134613 scopus 로고    scopus 로고
    • How nascent phagosomes mature to become phagolysosomes
    • Fairn, G.D., and Grinstein, S. (2012) How nascent phagosomes mature to become phagolysosomes. Trends Immunol 33: 397-405.
    • (2012) Trends Immunol , vol.33 , pp. 397-405
    • Fairn, G.D.1    Grinstein, S.2
  • 10
    • 59249085257 scopus 로고    scopus 로고
    • Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence
    • Ferrari, S., Ischer, F., Calabrese, D., Posteraro, B., Sanguinetti, M., Fadda, G., etal. (2009) Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence. PLoS Pathog 5: e1000268.
    • (2009) PLoS Pathog , vol.5
    • Ferrari, S.1    Ischer, F.2    Calabrese, D.3    Posteraro, B.4    Sanguinetti, M.5    Fadda, G.6
  • 11
    • 0344923836 scopus 로고    scopus 로고
    • Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C.albicans
    • Fidel, P.L., Vazquez, J.A., and Sobel, J.D. (1999) Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C.albicans. Clin Microbiol Rev 12: 80-96.
    • (1999) Clin Microbiol Rev , vol.12 , pp. 80-96
    • Fidel, P.L.1    Vazquez, J.A.2    Sobel, J.D.3
  • 12
    • 84876447241 scopus 로고    scopus 로고
    • Vps factors are required for efficient transcription elongation in budding yeast
    • Gaur, N.A., Hasek, J., Brickner, D.G., Qiu, H., Zhang, F., Wong, C.M., etal. (2013) Vps factors are required for efficient transcription elongation in budding yeast. Genetics 193: 829-851.
    • (2013) Genetics , vol.193 , pp. 829-851
    • Gaur, N.A.1    Hasek, J.2    Brickner, D.G.3    Qiu, H.4    Zhang, F.5    Wong, C.M.6
  • 13
    • 40549093944 scopus 로고    scopus 로고
    • PI3K signaling of autophagy is required for starvation tolerance and virulence of Cryptococcus neoformans
    • Hu, G., Hacham, M., Waterman, S.R., Panepinto, J., Shin, S., Liu, X., etal. (2008) PI3K signaling of autophagy is required for starvation tolerance and virulence of Cryptococcus neoformans. J Clin Invest 118: 1186-1197.
    • (2008) J Clin Invest , vol.118 , pp. 1186-1197
    • Hu, G.1    Hacham, M.2    Waterman, S.R.3    Panepinto, J.4    Shin, S.5    Liu, X.6
  • 14
    • 0032732046 scopus 로고    scopus 로고
    • Rapid recruitment of late endosomes and lysosomes in mouse macrophages ingesting Candida albicans
    • Káposzta, R., Maródi, L., Hollinshead, M., Gordon, S., and da Silva, R.P. (1999) Rapid recruitment of late endosomes and lysosomes in mouse macrophages ingesting Candida albicans. J Cell Sci 112: 3237-3248.
    • (1999) J Cell Sci , vol.112 , pp. 3237-3248
    • Káposzta, R.1    Maródi, L.2    Hollinshead, M.3    Gordon, S.4    da Silva, R.P.5
  • 15
    • 34250617570 scopus 로고    scopus 로고
    • A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata
    • Kaur, R., Ma, B., and Cormack, B.P. (2007) A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata. Proc Natl Acad Sci USA 104: 7628-7633.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7628-7633
    • Kaur, R.1    Ma, B.2    Cormack, B.P.3
  • 16
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct vps34 phohatidylinositol 3-kinase complexes function in autophagy and carboxyeptidase Y sorting in Sacharomyces cerevisiae
    • Kihara, A., Noda, T., Ishihara, N., and Ohsumi, Y. (2001) Two distinct vps34 phohatidylinositol 3-kinase complexes function in autophagy and carboxyeptidase Y sorting in Sacharomyces cerevisiae. J Cell Biol 152: 519-530.
    • (2001) J Cell Biol , vol.152 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 17
    • 84893365690 scopus 로고    scopus 로고
    • Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans
    • Liu, Y., Solis, N.V., Heilmann, C.J., Phan, Q.T., Mitchell, A.P., Klis, F.M., and Filler, S.G. (2014) Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans. Eukaryot Cell 13: 279-287.
    • (2014) Eukaryot Cell , vol.13 , pp. 279-287
    • Liu, Y.1    Solis, N.V.2    Heilmann, C.J.3    Phan, Q.T.4    Mitchell, A.P.5    Klis, F.M.6    Filler, S.G.7
  • 18
    • 0035811478 scopus 로고    scopus 로고
    • The glyoxylate cycle is required for fungal virulence
    • Lorenz, M.C., and Fink, G.R. (2001) The glyoxylate cycle is required for fungal virulence. Nature 412: 83-86.
    • (2001) Nature , vol.412 , pp. 83-86
    • Lorenz, M.C.1    Fink, G.R.2
  • 19
    • 0034194152 scopus 로고    scopus 로고
    • Phosphoinositide signaling and the regulation of membrane trafficking in yeast
    • Odorizzi, G., Babst, M., and Emr, S.D. (2000) Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem Sci 25: 229-235.
    • (2000) Trends Biochem Sci , vol.25 , pp. 229-235
    • Odorizzi, G.1    Babst, M.2    Emr, S.D.3
  • 20
    • 33846284924 scopus 로고    scopus 로고
    • Autophagy in the pathogen Candida albicans
    • Palmer, G.E., Kelly, M.N., and Sturtevant, J.E. (2007) Autophagy in the pathogen Candida albicans. Microbiology 153: 51-58.
    • (2007) Microbiology , vol.153 , pp. 51-58
    • Palmer, G.E.1    Kelly, M.N.2    Sturtevant, J.E.3
  • 21
    • 0347473810 scopus 로고    scopus 로고
    • Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
    • Parsons, A.B., Brost, R.L., Ding, H., Li, Z., Zhang, C., Sheikh, B., etal. (2004) Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol 22: 62-69.
    • (2004) Nat Biotechnol , vol.22 , pp. 62-69
    • Parsons, A.B.1    Brost, R.L.2    Ding, H.3    Li, Z.4    Zhang, C.5    Sheikh, B.6
  • 22
    • 77950471425 scopus 로고    scopus 로고
    • Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-year analysis of susceptibilities of Candida Species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion
    • Pfaller, M.A., Diekema, D.J., Gibbs, D.L., Newell, V.A., Ellis, D., Tullio, V., etal. (2010) Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-year analysis of susceptibilities of Candida Species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion. J Clin Microbiol 48: 1366-1377.
    • (2010) J Clin Microbiol , vol.48 , pp. 1366-1377
    • Pfaller, M.A.1    Diekema, D.J.2    Gibbs, D.L.3    Newell, V.A.4    Ellis, D.5    Tullio, V.6
  • 23
    • 84866148796 scopus 로고    scopus 로고
    • Functional genomic analysis of Candida glabrata-macrophage interaction: role of chromatin remodeling in virulence
    • Rai, M.N., Balusu, S., Gorityala, N., Dandu, L., and Kaur, R. (2012) Functional genomic analysis of Candida glabrata-macrophage interaction: role of chromatin remodeling in virulence. PLoS Pathog 8: e1002863.
    • (2012) PLoS Pathog , vol.8
    • Rai, M.N.1    Balusu, S.2    Gorityala, N.3    Dandu, L.4    Kaur, R.5
  • 24
    • 77649201449 scopus 로고    scopus 로고
    • Autophagy supports Candida glabrata survival during phagocytosis
    • Roetzer, A., Gratz, N., Kovarik, P., and Schuller, C. (2010) Autophagy supports Candida glabrata survival during phagocytosis. Cell Microbiol 12: 199-216.
    • (2010) Cell Microbiol , vol.12 , pp. 199-216
    • Roetzer, A.1    Gratz, N.2    Kovarik, P.3    Schuller, C.4
  • 25
    • 79953163170 scopus 로고    scopus 로고
    • Immunity to fungal infections
    • Romani, L. (2011) Immunity to fungal infections. Nat Rev Immunol 11: 275-288.
    • (2011) Nat Rev Immunol , vol.11 , pp. 275-288
    • Romani, L.1
  • 26
    • 0027905021 scopus 로고
    • Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
    • Schu, P.V., Takegawa, K., Fry, M.J., Stack, J.H., Waterfield, M.D., and Emr, S.D. (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260: 88-91.
    • (1993) Science , vol.260 , pp. 88-91
    • Schu, P.V.1    Takegawa, K.2    Fry, M.J.3    Stack, J.H.4    Waterfield, M.D.5    Emr, S.D.6
  • 27
    • 80053077071 scopus 로고    scopus 로고
    • The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation
    • Seider, K., Brunke, S., Schild, L., Jablonowski, N., Wilson, D., Majer, O., etal. (2011) The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol 187: 3072-3086.
    • (2011) J Immunol , vol.187 , pp. 3072-3086
    • Seider, K.1    Brunke, S.2    Schild, L.3    Jablonowski, N.4    Wilson, D.5    Majer, O.6
  • 28
    • 84891611604 scopus 로고    scopus 로고
    • Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages
    • Seider, K., Gerwien, F., Kasper, L., Allert, S., Brunke, S., Jablonowski, N., etal. (2014) Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell 13: 170-183.
    • (2014) Eukaryot Cell , vol.13 , pp. 170-183
    • Seider, K.1    Gerwien, F.2    Kasper, L.3    Allert, S.4    Brunke, S.5    Jablonowski, N.6
  • 29
    • 33745685061 scopus 로고    scopus 로고
    • Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome
    • Slessareva, J.E., Routt, S.M., Temple, B., Bankaitis, V.A., and Dohlman, H.G. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126: 191-203.
    • (2006) Cell , vol.126 , pp. 191-203
    • Slessareva, J.E.1    Routt, S.M.2    Temple, B.3    Bankaitis, V.A.4    Dohlman, H.G.5
  • 30
    • 0027256130 scopus 로고
    • A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
    • Stack, J.H., Herman, P.K., Schu, P.V., and Emr, S.D. (1993) A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J 12: 2195-2204.
    • (1993) EMBO J , vol.12 , pp. 2195-2204
    • Stack, J.H.1    Herman, P.K.2    Schu, P.V.3    Emr, S.D.4
  • 31
    • 33947199781 scopus 로고    scopus 로고
    • Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae
    • Strahl, T., and Thorner, J. (2007) Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim Biophys Acta 1771: 353-404.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 353-404
    • Strahl, T.1    Thorner, J.2
  • 32
    • 84861216079 scopus 로고    scopus 로고
    • Sleeping with the enemy: how intracellular pathogens cope with a macrophage lifestyle
    • Thi, E.P., Lambertz, U., and Reiner, N.E. (2012) Sleeping with the enemy: how intracellular pathogens cope with a macrophage lifestyle. PLoS Pathog 8: e1002551.
    • (2012) PLoS Pathog , vol.8 , pp. e1002551
    • Thi, E.P.1    Lambertz, U.2    Reiner, N.E.3
  • 33
    • 0037022671 scopus 로고    scopus 로고
    • Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm
    • Tucker, S.C., and Casadevall, A. (2002) Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm. Proc Natl Acad Sci USA 99: 3165-3170.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3165-3170
    • Tucker, S.C.1    Casadevall, A.2
  • 34
    • 0025938876 scopus 로고
    • Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate
    • Walsh, J.P., Caldwell, K.K., and Majerus, P.W. (1991) Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. Proc Natl Acad Sci USA 88: 9184-9187.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9184-9187
    • Walsh, J.P.1    Caldwell, K.K.2    Majerus, P.W.3
  • 35
    • 84893354236 scopus 로고    scopus 로고
    • Candida albicans triggers NLRP3-mediated pyroptosis in macrophages
    • Wellington, M., Koselny, K., Sutterwala, F.S., and Krysan, D.J. (2014) Candida albicans triggers NLRP3-mediated pyroptosis in macrophages. Eukaryot Cell 13: 329-340.
    • (2014) Eukaryot Cell , vol.13 , pp. 329-340
    • Wellington, M.1    Koselny, K.2    Sutterwala, F.S.3    Krysan, D.J.4
  • 37
    • 58849167699 scopus 로고    scopus 로고
    • The isolation and characterization of murine macrophages
    • 14.1:14.1.1-141-114
    • Zhang, X., Goncalves, R., and Mosser, D.M. (2008) The isolation and characterization of murine macrophages. Curr Protoc Immunol 83: 14.1:14.1.1-141-114.
    • (2008) Curr Protoc Immunol , vol.83
    • Zhang, X.1    Goncalves, R.2    Mosser, D.M.3


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