Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

Experimental Neurology

Volumn 265, Issue , 2015, Pages 48-58

  Yang, Sujeong ^a   Cacquevel, Matthias ^b   Saksida, Lisa M ^c,d   Bussey, Timothy J ^c,d   Schneider, Bernard L ^b   Aebischer, Patrick ^b   Melani, Riccardo ^e   Pizzorusso, Tommaso ^e,f   Fawcett, James W ^a   Spillantini, Maria Grazia ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b EPFL   (Switzerland)

^c UK   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e CNR   (Italy)

^f UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Chondroitinase ABC; Memory dementia perineuronal net; Microtubule associated protein; Object recognition TEST; Tauopathy

Indexed keywords

CHONDROITIN ABC LYASE; TAU PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; MALE; MEMORY DISORDER; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PERINEURONAL NET; PERIRHINAL CORTEX; PROTEIN PHOSPHORYLATION; SYNAPTIC TRANSMISSION; TAUOPATHY; ANIMAL; BRAIN CORTEX; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; HUMAN; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MEMORY; NERVE CELL NETWORK; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; TAUOPATHIES; TRANSGENIC MOUSE;

ANIMALS; CEREBRAL CORTEX; CHONDROITIN ABC LYASE; HUMANS; INJECTIONS, INTRAVENTRICULAR; MALE; MEMORY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE NET; NEURONAL PLASTICITY; ORGAN CULTURE TECHNIQUES; TAUOPATHIES;

EID: 84921445315     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.11.013     Document Type: Article

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