Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells

Biological Chemistry

Volumn 396, Issue 2, 2015, Pages 153-162

  Maeda, Yuma ^a   Sekiguchi, Fumiko ^a   Yamanaka, Rumi ^a   Sugimoto, Ryo ^a   Yamasoba, Daichi ^a   Tomita, Shiori ^a   Nishikawa, Hiroyuki ^a   Kawabata, Atsufumi ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

Cyclooxygenase 2 (COX 2); EP receptor; mouse osteoblastic MC3T3 E1 cell; prostaglandin E2; proteinase activated receptor 1 (PAR1)

Indexed keywords

ARACHIDONIC ACID; CHELATING AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROSTAGLANDIN E2; PROTEIN; PROTEIN KINASE C INHIBITOR; PROTEIN PAR1; PROTEIN PAR4; PROTEIN TYROSINE KINASE INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; NONHUMAN; ONCOGENE SRC; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; METABOLISM; MOUSE; PHOSPHORYLATION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; DINOPROSTONE; MICE; OSTEOBLASTS; PHOSPHORYLATION; RECEPTOR, PAR-1;

EID: 84921329729     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2014-0148     Document Type: Article

References (32)

1. Abraham, L.A. and MacKie, E.J. (1999). Modulation of osteoblast-like cell behavior by activation of protease-activated receptor-1. J. Bone Miner. Res. 14, 1320-1329.
2. Adams, J.P., Roberson, E.D., English, J.D., Selcher, J.C., and Sweatt, J.D. (2000). MAPK regulation of gene expression in the central nervous system. Acta Neurobiol. Exp. (Wars) 60, 377-394.
3. Akiba, S. and Sato, T. (2004). Cellular function of calcium-independent phospholipase A2. Biol. Pharm. Bull. 27, 1174-1178.
4. Blackwell, K.A., Raisz, L.G., and Pilbeam, C.C. (2010). Prostaglandins in bone: bad cop, good cop? Trends Endocrinol. Metab. 21, 294-301.
5. Bluteau, G., Pilet, P., Bourges, X., Bilban, M., Spaethe, R., Daculsi, G., and Guicheux, J. (2006). The modulation of gene expression in osteoblasts by thrombin coated on biphasic calcium phosphate ceramic. Biomaterials 27, 2934-2943.
6. Cummings, B.S. (2007). Phospholipase A2 as targets for anti-cancer drugs. Biochem. Pharmacol. 74, 949-959.
7. Das, S., Rafter, J.D., Kim, K.P., Gygi, S.P., and Cho, W. (2003). Mechanism of group IVA cytosolic phospholipase A2 activation by phosphorylation. J. Biol. Chem. 278, 41431-41442.
8. Dessen, A. (2000). Structure and mechanism of human cytosolic phospholipase A2. Biochim. Biophys. Acta. 1488, 40-47.
9. Graham, S., Gamie, Z., Polyzois, I., Narvani, A.A., Tzafetta, K., Tsiridis, E., Helioti, M., Mantalaris, A., and Tsiridis, E. (2009). Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: in vivo and in vitro evidence. Expert Opin. Invest. Drugs 18, 746-766.
10. Hatae, N., Yamaoka, K., Sugimoto, Y., Negishi, M., and Ichikawa, A. (2002). Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gβγsubunit-independent manner. Biochem. Biophys. Res. Commun. 290, 162-168.
11. Kawabata, A. (2002). PAR-2: structure, function and relevance to human diseases of the gastric mucosa. Expert Rev. Mol. Med. 4, 1-17.
12. Kawabata, A., Matsunami, M., and Sekiguchi, F. (2008). Gastrointestinal roles for proteinase-activated receptors in health and disease. Br. J. Pharmacol. 153, S230-S240.
13. Kawahara, K., Hohjoh, H., Inazumi, T., Tsuchiya, S., and Sugimoto, Y. (2014). Prostaglandin E-induced inflammation: relevance of prostaglandin E receptors. Biochim. Biophys. Acta Jul 17, doi: 10.1016/j.bbalip.2014.07.008 [Epub ahead of print].
14. Kawao, N., Nagataki, M., Nagasawa, K., Kubo, S., Cushing, K., Wada, T., Sekiguchi, F., Ichida, S., Hollenberg, M.D., MacNaughton, W.K., et al. (2005). Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. J. Pharmacol. Exp. Ther. 315, 576-589.
15. Lin, C.C., Hsieh, H.L., Liu, S.W., Tseng, H.C., Hsiao, L.D., and Yang, C.M. (2014). BK induces cPLA2 expression via an autocrine loop involving COX-2-derived PGE2 in rat brain ystrocytes. Mol. Neurobiol., Jul 12 [Epub ahead of print].
16. Ljunggren, O., Johansson, H., Ljunghall, S., and Lerner, U.H. (1991). Thrombin increases cytoplasmic Ca2+ and stimulates formation of prostaglandin E2 in the osteoblastic cell line MC3T3-El. Bone Miner. 12, 81-90.
17. Mackie, E.J., Loh, L.H., Sivagurunathan, S., Uaesoontrachoon, K., Yoo, H.J., Wong, D., Georgy, S.R., and Pagel, C.N. (2008). Protease-activated receptors in the musculoskeletal system. Int. J. Biochem. Cell Biol. 40, 1169-1184.
18. Moriyuki, K., Sekiguchi, F., Matsubara, K., Nishikawa, H., and Kawabata, A. (2009). Proteinase-activated receptor-2-triggered prostaglandin E2 release, but not cyclooxygenase-2 upregulation, requires activation of the phosphatidylinositol 3-kinase/Akt/nuclear factor-?B pathway in human alveolar epithelial cells. J. Pharmacol. Sci. 111, 269-275.
19. Murakami, M. and Kudo, I. (2002). Phospholipase A2. J. Biochem. 131, 285-292.
20. Nakanishi-Matsui, M., Zheng, Y.W., Sulciner, D.J., Weiss, E.J., Ludeman, M.J., and Coughlin, S.R. (2000). PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404, 609-613.
21. O'Neill, K.R., Stutz, C.M., Mignemi, N.A., Cole, H., Murry, M.R., Nyman, J.S., Hamm, H., and Schoenecker, J.G. (2012). Fracture healing in protease-activated receptor-2 deficient mice. J. Orthop. Res. 30, 1271-1276.
22. Ossovskaya, V.S. and Bunnett, N.W. (2004). Protease-activated receptors: contribution to physiology and disease. Physiol. Rev. 84, 579-621.
23. Pagel, C.N., Song, S.J., Loh, L.H., Tudor, E.M., Murray-Rust, T.A., Pike, R.N., and Mackie, E.J. (2009). Thrombin-stimulated growth factor and cytokine expression in osteoblasts is mediated by protease-activated receptor-1 and prostanoids. Bone 44, 813-821.
24. Pai, R., Soreghan, B., Szabo, I.L., Pavelka, M., Baatar, D., and Tarnawski, A.S. (2002). Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat. Med. 8, 289-293.
25. Pham, H., Shafer, L.M., and Slice, L.W. (2006). CREB-dependent cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression is mediated by protein kinase C and calcium. J. Cell. Biochem. 98, 1653-1666.
26. Ramachandran, R. and Hollenberg, M.D. (2008). Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br. J. Pharmacol. 153 (Suppl. 1), S263-282.
27. Sands, W.A. and Palmer, T.M. (2008). Regulating gene transcription in response to cyclic AMP elevation. Cell Signal. 20, 460-466.
28. Sekiguchi, F., Saito, S., Takaoka, K., Hayashi, H., Nagataki, M., Nagasawa, K., Nishikawa, H., Matsui, H., and Kawabata, A. (2007a). Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells. Biochem. Pharmacol. 73, 103-114.
29. Sekiguchi, F., Takaoka, K., and Kawabata, A. (2007b). Proteinaseactivated receptors in the gastrointestinal system: a functional linkage to prostanoids. Inflammopharmacology 15, 246-251.
30. Song, S.J., Pagel, C.N., Campbell, T.M., Pike, R.N., and Mackie, E.J. (2005a). The role of protease-activated receptor-1 in bone healing. Am. J. Pathol. 166, 857-868.
31. Song, S.J., Pagel, C.N., Pike, R.N., and Mackie, E.J. (2005b). Studies on the receptors mediating responses of osteoblasts to thrombin. Int. J. Biochem. Cell Biol. 37, 206-213.
32. Wang, H., Wen, S., Bunnett, N.W., Leduc, R., Hollenberg, M.D., and MacNaughton, W.K. (2008). Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through ?-catenin and cyclic AMP-response element-binding protein. J. Biol. Chem. 283, 809-815.