Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 583-607

  Khadka, Daulat Bikram ^a   Woo, Hyunjung ^b   Yang, Su Hui ^a   Zhao, Chao ^a   Jin, Yifeng ^a   Le, Thanh Nguyen ^c   Kwon, Youngjoo ^b   Cho, Won Jea ^a  

^a Chonnam National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Viet Nam)

Author keywords

3,4 Diarylisoquinoline; Molecular docking; Selective cytotoxicity; Suzuki coupling; Topoisomerase

Indexed keywords

1 (4 ETHYLPIPERAZIN 1 YL) 4 (3 METHOXYPHENYL) 6 METHYL 3 (3 TOLYL)ISOQUINOLINE; 1 CHLORO 3 (2 METHOXYPHENYL) 4 (3 METHOXYPHENYL) ISOQUINOLINE; 1 CHLORO 3 (2,6 DIMETHOXYPHENYL) 4 (3 METHOXYPHENYL) 6 METHYLISOQUINOLINE; 1 CHLORO 3 (3,4 DIMETHOXYPHENYL) 4 (3 METHOXYPHENYL) 6 METHYLISOQUINOLINE; 1 CHLORO 4 (3 METHOXYPHENYL) 3 (4 METHOXYPHENYL) ISOQUINOLINE; 1 CHLORO 4 (3 METHOXYPHENYL) 6 METHYL 3 (2 TOLYL) ISOQUINOLINE; 1 CHLORO 4 (3 METHOXYPHENYL) 6 METHYL 3 (3 TOLYL) ISOQUINOLINE; 2 [4 [4 (3 METHOXYPHENYL) 6 METHYL 3 (3 TOLYL) ISOQUINOLIN 1 YL]PIPERAZIN 1 YL] N,N DIMETHYLETHANAMINE; 3 (2 METHOXYPHENYL) 4 (3 METHOXYPHENYL)ISOQUINOLIN 1(2H) ONE; 3 (2,6 DIMETHOXYPHENYL) 4 (3 METHOXYPHENYL) 6 METHYLISOQUINOLIN 1(2H) ONE; 3 (3,4 DIMETHOXYPHENYL) 4 (3 METHOXYPHENYL) 6 METHYL 1 (4 METHYLPIPERAZIN 1 YL)ISOQUINOLINE; 3 (3,4 DIMETHOXYPHENYL) 4 (3 METHOXYPHENYL) 6 METHYL 1 (PIPERAZIN 1 YL)ISOQUINOLINE; 3 (3,4 DIMETHOXYPHENYL) 4 (3 METHOXYPHENYL) 6 METHYLISOQUINOLIN 1(2H) ONE; 3 ARYL 1 CHLORO 4 (3 METHOXYPHENYL)ISOQUINOLINE; 3 ARYL 4 (3 METHOXYPHENYL)ISOQUINOLIN 1(2H) ONE; 3,4 DIARYLISOQUINOLINE DERIVATIVE; 4 (3 METHOXYPHENYL) 3 (4 METHOXYPHENYL)ISOQUINOLIN 1(2H) ONE; 4 (3 METHOXYPHENYL) 6 METHYL 3 (2 TOLYL)ISOQUINOLIN 1(2H) ONE; 4 (3 METHOXYPHENYL) 6 METHYL 3 (3 TOLYL)ISOQUINOLIN 1(2H) ONE; 4 (3 METHOXYPHENYL) 6 METHYL N (4 METHYLPIPERAZIN 1 YL) 3 (2 TOLYL)ISOQUINOLIN 1 AMINE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; ISOQUINOLINE DERIVATIVE; N (1 ETHYLPIPERIDIN 4 YL) 4 (3 METHOXYPHENYL) 6 METHYL 3 (2 TOLYL)ISOQUINOLIN 1 AMINE; N (1 ETHYLPIPERIDIN 4 YL) 4 (3 METHOXYPHENYL) 6 METHYL 3 (3 TOLYL)ISOQUINOLIN 1 AMINE; N (4 METHOXYBENZYL) 4 (3 METHOXYPHENYL) 6 METHYL 3 (2 TOLYL)ISOQUINOLIN 2 AMINE; N BENZYL 4 (3 METHOXYPHENYL) 6 METHYL 3 (2 TOLYL)ISOQUINOLIN 1 AMINE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BROMINATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; HYDROGEN BOND; MALE; MOLECULAR DOCKING; PROSTATE CANCER; SUZUKI REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOQUINOLINES; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 84921261621     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.01.016     Document Type: Article

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