Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 980, Issue , 2015, Pages 88-93

  Liu, Xiao ^a,b   Li, Huan ^a,c   Wu, Li ^a   Xing, Jiangwa ^c   Poh, Yanhong ^d   Cai, Hao ^a   Cai, Bao Chang ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b CLEVELAND STATE UNIVERSITY   (United States)

^c INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^d SCHOOL OF APPLIED SCIENCE   (Singapore)

Author keywords

Chrysophanol; MRM; Pharmacokinetics; Physcion; UFLC MS MS

Indexed keywords

BODY FLUIDS; C (PROGRAMMING LANGUAGE); CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; DRUG DOSAGE; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERFERENCE SUPPRESSION; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; RATS; VOLATILE FATTY ACIDS;

CHRYSOPHANOL; MRM; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC PARAMETERS; PHYSCION; UFLC-MS/MS; ULTRA-FAST LIQUID CHROMATOGRAPHY; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

LIQUID CHROMATOGRAPHY;

AMMONIUM ACETATE; CHRYSOPHANIC ACID; DAHUANG FUZI DECOCTION; METHANOL; PHYSCION; PLANT MEDICINAL PRODUCT; RHUBARB EXTRACT; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; EMODIN; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ARTICLE; DRUG MECHANISM; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; NONHUMAN; PRESCRIPTION; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ACONITE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES;

RATTUS;

ACONITUM; ANIMALS; ANTHRAQUINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; EMODIN; RATS; TANDEM MASS SPECTROMETRY;

EID: 84921064779     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.11.025     Document Type: Article

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