Silk fibroin/gelatin electrospun nanofibrous dressing functionalized with astragaloside IV induces healing and anti-scar effects on burn wound

International Journal of Pharmaceutics

Volumn 479, Issue 2, 2015, Pages 291-301

  Shan, Ying Hui ^a   Peng, Li Hua ^a   Liu, Xin ^b   Chen, Xi ^a   Xiong, Jie ^b   Gao, Jian Qing ^a,c  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG SCI TECH UNIVERSITY   (China)

^c Jiangsu Engineering Research Center for New Type External and Transdermal Preparations   (China)

Author keywords

Astragaloside IV; Burn; Nanofibrous dressing; Scar inhibition; Wound healing

Indexed keywords

ASTRAGALOSIDE IV; COLLAGEN; GELATIN; NANOFIBER; SILK FIBROIN; ASTRAGALOSIDE A; FIBROIN; SAPONIN; SILK; TRITERPENE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; BURN; BURN DRESSING; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELECTROSPINNING; IMMUNOHISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; NANOTECHNOLOGY; NONHUMAN; POROSITY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SCAR FORMATION; STIMULATION; SWELLING; WOUND CLOSURE; WOUND HEALING; ANIMAL; BANDAGE; BURNS; CHEMISTRY; CICATRIX; COMPLICATION; DRUG EFFECTS; METABOLISM; PATHOLOGY; SKIN; SPRAGUE DAWLEY RAT;

ANIMALS; BANDAGES; BURNS; CELL ADHESION; CICATRIX; COLLAGEN; DRUG DELIVERY SYSTEMS; FIBROINS; GELATIN; NANOFIBERS; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; SILK; SKIN; TRITERPENES; WOUND HEALING;

EID: 84921044743     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.12.067     Document Type: Article

References (36)

1. C. Acharya, S.K. Ghosh, and S.C. Kundu Silk fibroin film from non-mulberry tropical tasar silkworms: a novel substrate for in vitro fibroblast culture Acta Biomater. 5 2009 429 437
2. G.H. Altman, F. Diaz, C. Jakuba, T. Calabro, R.L. Horan, J. Chen, H. Lu, J. Richmond, and D.L. Kaplan Silk-based biomaterials Biomaterials 24 2003 401 416
3. P.A. Brigham, and E. McLoughlin Burn incidence and medical care use in the United States: estimates trends, and data sources J. Burn Care Rehabil. 17 1996 95 107
4. X. Chen, L.H. Peng, N. Li, Q.M. Li, P. Li, K.P. Fung, P.C. Leung, and J.Q. Gao The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo J. Ethnopharmacol. 139 2012 721 727
5. X. Chen, L.H. Peng, Y.H. Shan, N. Li, W. Wei, L. Yu, Q.M. Li, W.Q. Liang, and J.Q. Gao Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery Int. J. Pharm. 447 2013 171 181
6. A.O. Elzoghby, W.M. Samy, and N.A. Elgindy Protein-based nanocarriers as promising drug and gene delivery systems J. Control. Release 161 2012 38 49
7. V. Falanga The chronic wound: impaired healing and solutions in the context of wound bed preparation Blood Cell Mol. Dis. 32 2004 88 94
8. T.M. Freyman, I.V. Yannas, and L.J. Gibson Cellular materials as porous scaffolds for tissue engineering Prog. Mater. Sci. 46 2001 273 282
9. D.W. Friedman, C.D. Boyd, J.W. Mackenzie, P. Norton, R.M. Olson, and S.B. Deak Regulation of collagen gene expression in keloids and hypertrophic scars J. Surg. Res. 55 1993 214 222
10. M. Hromadka, J.B. Collins, C. Reed, L. Han, K.K. Kolappa, B.A. Cairns, T. Andrady, and J.A. van Aalst Nanofiber applications for burn care J. Burn Care Res. 29 2008 695 703
11. B. Jankovic, J. Pelipenko, M. Skarabot, I. Musevic, and J. Kristl The design trend in tissue-engineering scaffolds based on nanomechanical properties of individual electrospun nanofibers Int. J. Pharm. 455 2013 338 347
12. Z. Janzekovic A new concept in the early excision and immediate grafting of burns J. Trauma 10 1970 1103 1108
13. M.G. Jeschke, S. Shahrokhi, C.C. Finnerty, L.K. Branski, M. Dibildox, The A.B.A.O., delivery of burn care, C, and Delivery of Burn Care Committee Wound coverage technologies in burn care: established techniques J. Burn Care Res. 2013 10.1097/BCR.0b013e3182920d29
14. T. Kondo, and Y. Ishida Molecular pathology of wound healing Forensic Sci. Int. 203 2010 93 98
15. K.H. Kwan, X. Liu, M.K. To, K.W. Yeung, C.M. Ho, and K.K. Wong Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing Nanomed. Nanotechnol. Biol. Med. 7 2011 497 504
16. J.L. Li, J.L. Pan, L.G. Zhang, and Y.T. Yu Culture of hepatocytes on fructose-modified chitosan scaffolds Biomaterials 24 2003 2317 2322
17. Y. Lu, H. Jiang, K. Tu, and L. Wang Mild immobilization of diverse macromolecular bioactive agents onto multifunctional fibrous membranes prepared by coaxial electrospinning Acta Biomater. 5 2009 1562 1574
18. L. Meinel, S. Hofmann, V. Karageorgiou, C. Kirker-Head, J. McCool, G. Gronowicz, L. Zichner, R. Langer, G. Vunjak-Novakovic, and D.L. Kaplan The inflammatory responses to silk films in vitro and in vivo Biomaterials 26 2005 147 155
19. H. Meng, L. Chen, Z. Ye, S. Wang, and X. Zhao The effect of a self-assembling peptide nanofiber scaffold (peptide) when used as a wound dressing for the treatment of deep second degree burns in rats J. Biomed. Mater. Res. B Biomater 89B 2009 379 391
20. S.W. Merrell, J.R. Saffle, C.M. Larson, and J.J. Sullivan The declining incidence of fatal sepsis following thermal injury J. Trauma 29 1989 1362 1366
21. M. Okhawilai, R. Rangkupan, S. Kanokpanont, and S. Damrongsakkul Preparation of Thai silk fibroin/gelatin electrospun fiber mats for controlled release applications Int. J. Biol. Macromol. 46 2010 544 550
22. L.H. Peng, K.P. Fung, P.C. Leung, and J.Q. Gao Genetically manipulated adult stem cells for wound healing Drug Discov. Today 16 2011 957 966
23. L.H. Peng, X. Chen, L. Chen, N. Li, W.Q. Liang, and J.Q. Gao Topical astragaloside IV-releasing hydrogel improves healing of skin wounds in vivo Biol. Pharm. Bull. 35 2012 881 888
24. L.H. Peng, S.Y. Tsang, Y. Tabata, and J.Q. Gao Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration J. Control. Release 157 2012 321 330
25. L.H. Peng, Z.Y. Mao, X.T. Qi, X. Chen, N. Li, Y. Tabata, and J.Q. Gao Transplantation of bone-marrow-derived mesenchymal and epidermal stem cells contribute to wound healing with different regenerative features Cell Tissue Res. 352 2013 573 583
26. L.H. Peng, W. Wei, X.T. Qi, Y.H. Shan, F.J. Zhang, X. Chen, Q.Y. Zhu, L. Yu, W.Q. Liang, and J.Q. Gao Epidermal stem cells manipulated by pDNA-VEGF165/CYD-PEI nanoparticles loaded gelatin/beta-TCP matrix as a therapeutic agent and gene delivery vehicle for wound healing Mol. Pharm. 10 2013 3090 3102
27. J.M. Rhett, G.S. Ghatnekar, J.A. Palatinus, M. O'Quinn, M.J. Yost, and R.G. Gourdie Novel therapies for scar reduction and regenerative healing of skin wounds Trends Biotechnol. 26 2008 173 180
28. S. Sethuraman, L.S. Nair, S. El-Amin, M.T. Nguyen, A. Singh, N. Krogman, Y.E. Greish, H.R. Allcock, P.W. Brown, and C.T. Laurencin Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: side group effects Acta Biomater. 6 2010 1931 1937
29. J.D. Stitzel, K.J. Pawlowski, G.E. Wnek, D.G. Simpson, and G.L. Bowlin Arterial smooth muscle cell proliferation on a novel biomimicking, biodegradable vascular graft scaffold J. Biomater. Appl. 16 2001 22 33
30. A. Stojadinovic, E.A. Elster, K. Anam, D. Tadaki, M. Amare, S. Zins, and T.A. Davis Angiogenic response to extracorporeal shock wave treatment in murine skin isografts Angiogenesis 11 2008 369 380
31. K. Tonsomboon, D.G. Strange, and M.L. Oyen Gelatin nanofiber-reinforced alginate gel scaffolds for corneal tissue engineering Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2013 6671 6674.
32. X. Wen, and P.A. Tresco Fabrication and characterization of permeable degradable poly(-lactide-co-glycolide) (PLGA) hollow fiber phase inversion membranes for use as nerve tract guidance channels Biomaterials 27 2006 3800 3809
33. W. Xi-Qiao, L. Ying-Kai, Q. Chun, and L. Shu-Liang Hyperactivity of fibroblasts and functional regression of endothelial cells contribute to microvessel occlusion in hypertrophic scarring Microvasc. Res. 77 2009 204 211
34. E.K. Yim, and K.W. Leong Significance of synthetic nanostructures in dictating cellular response Nanomed. Nanotechnol. Biol. Med. 1 2005 10 21
35. G.B. Yin, Y.Z. Zhang, W.W. Bao, J.L. Wu, D.B. Shi, and Z.H. Dong Study on the properties of the electrospun silk fibroin/gelatin blend nanofibers for scaffolds J. Appl. Polym. Sci. 111 2009 1471 1477
36. S. Zhong, Y. Zhang, and C.T. Lim Fabrication of large pores in electrospun nanofibrous scaffolds for cellular infiltration: a review Tissue Eng. Part B 18 2012 77 87