TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2+ signaling in motor neurons

Neurobiology of Disease

Volumn 75, Issue , 2015, Pages 64-77

  Mutihac, R ^a,b   Alegre Abarrategui, J ^a   Gordon, D ^b   Farrimond, L ^b   Yamasaki Mann, M ^a,c   Talbot, K ^b   Wade Martins, R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bcl 2; Ca2+ dysregulation; Motor neurons; TDP 43

Indexed keywords

CALCIUM; CASPASE 3; PROTEIN BCL 2; SMALL INTERFERING RNA; TAR DNA BINDING PROTEIN; THAPSIGARGIN; BCL2 PROTEIN, HUMAN; BCL2 PROTEIN, MOUSE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; DNA BINDING PROTEIN; TDP-43 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MOTONEURON; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; SPINAL CORD MOTONEURON; TARDBP GENE; UPREGULATION; ANIMAL; BACTERIAL ARTIFICIAL CHROMOSOME; CELL CULTURE; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CALCIUM; CASPASE 3; CELLS, CULTURED; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CYTOPLASM; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION, MISSENSE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; SPINAL CORD;

EID: 84921038796     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.12.010     Document Type: Article

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