Mass spectrometric evaluation of mephedrone in vivo human metabolism: Identification of phase i and phase II metabolites, including a novel succinyl conjugate

Drug Metabolism and Disposition

Volumn 43, Issue 2, 2015, Pages 248-257

  Pozo, Óscar J ^a   Ibáñez, Maria ^b   Sancho, Juan V ^b   Lahoz Beneytez, Julio ^c,d   Farré, Magi ^c   Papaseit, Esther ^c   De La Torre, Rafael ^c   Hernández, Félix ^b  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITAT JAUME I   (Spain)

^c INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^d UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4' METHYLMETHCATHINONE; AMINOKETONE; CYTOCHROME P450 2D6; DRUG METABOLITE; N SUCCINYL NORMEPHEDRONE; SUCCINIC ACID; UNCLASSIFIED DRUG; DESIGNER DRUG; METHAMPHETAMINE;

ARTICLE; DRUG CONJUGATION; DRUG HYDROXYLATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MASS SPECTROMETRY; NORMAL HUMAN; QUADRUPOLE MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; ADULT; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DETOXIFICATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLISM; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TOXICOKINETICS; URINE;

RATTUS;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESIGNER DRUGS; HUMANS; MALE; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; METHAMPHETAMINE; MOLECULAR STRUCTURE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TOXICOKINETICS;

EID: 84921031065     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.061416     Document Type: Article

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