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Volumn 9, Issue 11, 2014, Pages 2516-2527

Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres

(5) Gehringer, Matthias a Forster, Michael a Pfaffenrot, Ellen a Bauer, Silke M a Laufer, Stefan A a

a UNIVERSITY OF TÜBINGEN (Germany)

Author keywords

bioisosteres; cytokines; inflammation; Janus kinase; structure activity relationships

Indexed keywords

JANUS KINASE 3 INHIBITOR; RUXOLITINIB; TOFACITINIB; TOFACITINIB BIOISOSTERE DERIVATIVE; TRICYCLIC INHIBITOR; UNCLASSIFIED DRUG; JANUS KINASE 3; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; HYDROGEN BONDING; JANUS KINASE 3; PIPERIDINES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84921023407 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201402252 Document Type: Article

Times cited : (26)

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