Mild and efficient DBU-catalyzed amidation of cyanoacetates

Organic Letters

Volumn 11, Issue 9, 2009, Pages 2003-2006

  Price, Kristin E ^a   Larrivee Aboussafy, Claude ^a   Lillie, Brett M ^a   McLaughlin, Robert W ^a   Mustakis, Jason ^a   Hettenbach, Kevin W ^a   Hawkins, Joel M ^a   Vaidyanathan, Rajappa ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAZABICYCLO[2.2.2]OCTANE; 1,8 DIAZABICYCLO(5.4.0)UNDEC 7 ENE; 1,8-DIAZABICYCLO(5.4.0)UNDEC-7-ENE; ACETIC ACID DERIVATIVE; AMIDE; CP 690,550 10; CP-690,550-10; CYANOACETIC ACID; FUSED HETEROCYCLIC RINGS; IMMUNOSUPPRESSIVE AGENT; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; SYNTHESIS;

ACETIC ACIDS; AMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; IMMUNOSUPPRESSIVE AGENTS; MOLECULAR STRUCTURE; PIPERAZINES; PYRIMIDINES; PYRROLES;

EID: 65549151322     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol900435t     Document Type: Article

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31. 1/2 = 16 h with 0.5 equiv of DBU in 2-MeTHF at 40 °C). Significant rate enhancements have been observed in the amidation of acyl imidazoles as well. Larrivee- Aboussafy, C.; Price, K. E.; Hawkins, J. M.; Vaidyanathan, R. Manuscript in preparation.