Profiling and multivariate statistical analysis of Panax ginseng based on ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 107, Issue , 2015, Pages 141-150

  Wu, Wei ^a   Sun, Le ^a   Zhang, Zhe ^a   Guo, Yingying ^a   Liu, Shuying ^a,b  

^a CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

^b CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

Author keywords

Chemical profiling; Ginsenoside; Identification; Panax ginseng; UHPLC Q TOF MS

Indexed keywords

CHIKUSETSU SAPONIN; GINSENOSIDE; GINSENOSIDE F 2; GINSENOSIDE MRA 1; GINSENOSIDE MRA 2; GINSENOSIDE MRA 3; GINSENOSIDE MRB 1; GINSENOSIDE MRB 2; GINSENOSIDE MRB 3; GINSENOSIDE MRC; GINSENOSIDE MRD; GINSENOSIDE MRE; GINSENOSIDE NOTO R2; GINSENOSIDE NOTOR 1; GINSENOSIDE RA 1; GINSENOSIDE RA 2; GINSENOSIDE RA 3; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RE 1; GINSENOSIDE RF; GINSENOSIDE RG 1; GINSENOSIDE RG 3; GINSENOSIDE RG 4; GINSENOSIDE RH 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; PLANT EXTRACT;

ARTICLE; CONTROLLED STUDY; DRUG ANALYSIS; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG MANUFACTURE; DRUG MIXTURE; ENANTIOMER; GINSENG; HIGH TEMPERATURE; ISOMER; MOLECULAR WEIGHT; PRIORITY JOURNAL; QUALITY CONTROL; SIGNAL NOISE RATIO; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; MULTIVARIATE ANALYSIS; PANAX; PROCEDURES; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GINSENOSIDES; HYDROLYSIS; MASS SPECTROMETRY; MULTIVARIATE ANALYSIS; PANAX; PLANT EXTRACTS; TANDEM MASS SPECTROMETRY;

EID: 84921019896     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.12.030     Document Type: Article

References (34)

1. Coleman C.I., Hebert J.H., Reddy P. The effects of Panax ginseng on quality of life. J. Clin. Pharm. Ther. 2003, 28:5-15.
2. Kennedy D.O., Scholey A.B. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol. Biochem. Behav. 2003, 75:687-700.
3. Jia L., hao Y. Current evaluation of the millennium phytomedicine-Ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr. Med. Chem. 2009, 16:2475-2484.
4. Attele A.S., Wu J.A., Yuan C. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 1999, 58:1685-1693.
5. Angelova N., Kong H., Heijden R.V.D., Yang S., Choi Y.H., Kim H.K., Hankemeier T., Greef J.V.D., Xu G., Verproorte R. Recent methodology in the phytochemical analysis of ginseng. Phytochem. Anal. 2008, 19:2-16.
6. Liu C., Xiao P. Recent advances on ginseng research in China. J. Ethnopharmacol. 1992, 36:27-38.
7. Lü J., Yao Q., Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr. Vasc. Pharmacol. 2009, 7:293-302.
8. Fuzzati N. Analysis methods of ginsenosides. J. Chromatogr. B 2004, 812:119-133.
9. Kong H., Wang M., Van Der Heijden R., Van Der Greef J., Hankemeier T., Xu G. Separation and identification of malonyl-ginsenosides in white ginseng using HPLC-LTQ-FTMS. World Sci. Technol./Mod. Tradit. Chin. Med. 2009, 11:190-194.
10. Kite G.C., Howes M.J.R., Leon C., Simmonds M.S.J. Liquid chromatography/mass spectrometry of malonyl-ginsenosides in the authentication of ginseng. Rapid Commun. Mass Spectrom. 2003, 17:238-244.
11. Li X., Guo R., Li L. Pharmacological variations of Panax ginseng C. A. Meyer during processing. China J. Chin. Mater. Med. 1991, 16:3-7.
12. Zhang H., Li S., Zhang H., Wang Y., Zhao Z., Chen S., Xu H. Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach. J. Pharm. Biomed. Anal. 2012, 62:258-273.
13. Xie Y., Luo D., Cheng Y., Ma J., Wang Y., Liang Q., Luo G. Steaming-induced chemical transformations and holistic quality assessment of red ginseng derived from Panax ginseng by means of HPLC-ESI-MS/MSn-based multicomponent quantification fingerprint. J. Agric. Food Chem. 2012, 60:8213-8224.
14. Yue P.Y.K., Mak N.K., Cheng Y.K., Leung K.W., Ng T.B., Fan D.T.P., Yeung H.W., Wong R.N.S. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin. Med. 2007, 2:1-21.
15. Yue P.Y.K., Wong D.Y.L., Wu P.K., Leung P.Y., Mark N.K., Yeung H.W. The angiosuppressive effects of 20(R)-ginsenoside Rg3. Biochem. Pharmacol. 2006, 72:437-445.
16. Lee J.I., Ha Y.W., Choi T.W., Kim H.J., Kim S.M., Jang H.J., Choi J.H., Choi M.H., Chung B.C., Sethi G., Kim S.H., Ahn K.S., Choi S.H., Shim B.S., Ahn K.S. Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells. Planta Med. 2011, 77:133-140.
17. Zhang X., Song F., Cui M., Liu Z., Liu S. Investigation of the hydrolysis of ginsenosides by high performance liquid chromatograph-electrospray ionization mass spectrometry. Planta Med. 2007, 73:1225-1229.
18. Li S., Lai S., Song J., Qiao C., Liu X., Zhou Y., Cai H., Cai B., Xu H. Decocting-induced chemical transformations and global quality of Du-Shen-Tang, the decoction of ginseng evaluated by UPLC-Q-TOF-MS/MS based chemical profiling approach. J. Pharm. Biomed. Anal. 2010, 53:946-957.
19. Zhang X., Wang L.N., Song F.R., Liu Z.Q., Liu S.Y. Study on the variation of chemical constituents during combination of Ginseng with Trogopteroum Feces and Semen Raphani by high performance liquid chromatography mass spectrometry. Chin. J. Anal. Chem. 2007, 35:559-563.
20. Kwon S.W., Han S.B., Park I.H., Kim J.M., Park M.K., Park J.H. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J. Chromatogr. A 2001, 921:335-339.
21. Ha Y.W., Lim S.S., Ha I.J., Na Y., Seo J., Shin H., Son S.H., Kim Y.S. Preparative isolation of four ginsenosides from Koren red ginseng (steam-treated Panax ginseng C. A. Meyer) by high-speed counter-current chromatography coupled with evaporative light scattering detection. J. Chromatogr. A 2007, 1151:37-44.
22. Kim W.Y., Kim J.M., Han S.B., Lee S.K., Kim N.D., Park M.K., Kim C.K., Park J.H. Steaming of ginseng at high temperature enhances biological activity. J. Nat. Prod. 2000, 63:1702-1704.
23. Wang X., Su M., Qiu Y., Ni Y., Zhao T., Zhou M., Zhao A., Yang S., Zhao L., Jia W. Metabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention. J. Proteome Res. 2007, 6:3449-3455.
24. Kong H., Wang M., Venema K., Maathuis A., Van der Heijden R., Van der Greef J., Xu G., Hankemeier T. Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry. J. Chromatogr. A 2009, 1216:2195-2203.
25. Chan E.C.Y., Yap S., Lau A., Leow P., Toh D., Koh H. Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rapid Commun. Mass Spectrom. 2007, 21:519-528.
26. Dan M., Su M., Gao X., Zhao T., Zhao A., Xie G., Qiu Y., Zhou M., Liu Z., Jia W. Metabolite profiling of Panax notoginseng using UPLC-ESI-MS. Phytochemistry 2008, 69:2237-2244.
27. Xie G.X., Plumb R., Su M.M., Xu Z.H., Zhao A.H., Qiu M.F., Long X.B., Liu Z., Jia W. Ultra-performance LC/TOFMS analysis of medicinal Panax herbs for metabolomic research. J. Sep. Sci. 2008, 31:1015-1026.
28. Sun J., Chen P. Differentiation of Panax quinquefolius grown in the USA and China using LC/MS-based chromatographic fingerprinting and chemometric approaches. Anal. Bioanal. Chem. 2011, 399:1877-1889.
29. Domon B., Costello C.E. A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates. Glycoconj. J. 1988, 5:397-409.
30. Perreault H., Costello C.E. Liquid secondary ionization tandem and matrix-assisted laser desorption/ionization time-of-flight mass spectrometric characterization of glycosphingolipid derivatives. Org. Mass Spectrom. 1994, 29:720-735.
31. Liu S., Cui M., Liu Z., Song F. Structural analysis of saponins from medicinal herbs using electrospray ionization tandem mass spectrometry. J. Am. Soc. Mass Spectrom. 2004, 15:133-141.
32. Wu W., Qin Q., Guo Y., Sun J., Liu S. Studies on the chemical transformation of 20(S)-PPT-type ginsenosides Re, Rg2, and Rf by using RRLC-Q-TOF-MS. J. Agric. Food Chem. 2012, 60:10007-10014.
33. Sengupta S., Toh S., Sellers L.A., Skepper J.N., Koolwijk P., Leung H.W., Yeung H., Wong R.N.S., Sasisekharan R., Fan T.D. Modulating angiogenesis: the Yin and Yang in Ginseng. Circulation 2004, 110:1219-1225.
34. Shi W., Wang Y., Li J., Zhang H., Ding L. Investigation of ginsenosides in different parts and ages of Panax ginseng. Food Chem. 2007, 102:664-668.