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Volumn 5, Issue DEC, 2014, Pages

UCH-L1 and GFAP serum levels in neonates with hypoxic-ischemic encephalopathy: A single center pilot study

Author keywords

Biomarkers; GFAP; HIE; UCH L1

Indexed keywords

BIOLOGICAL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; UBIQUITIN C TERMINAL HYDROLASE L1; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG;

EID: 84920995891     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2014.00273     Document Type: Article
Times cited : (55)

References (43)
  • 1
    • 0001038760 scopus 로고    scopus 로고
    • Hypoxia ischemia: pathogenesis and neuropathology
    • Fanaroff A, editor. 6th ed. St. Louis, MO: Mosby
    • Vannucci R. Hypoxia ischemia: pathogenesis and neuropathology. In: Fanaroff A, editor. Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 6th ed. St. Louis, MO: Mosby (1997). p. 856-91.
    • (1997) Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant , pp. 856-891
    • Vannucci, R.1
  • 2
    • 0025049840 scopus 로고
    • Selective vulnerability of cultured cortical glia to injury by extracellular acidosis
    • Giffard RG, Monyer H, Choi DW. Selective vulnerability of cultured cortical glia to injury by extracellular acidosis. Brain Res (1990) 530(1):138-41. doi: 10.1016/0006-8993(90)90670-7
    • (1990) Brain Res , vol.530 , Issue.1 , pp. 138-141
    • Giffard, R.G.1    Monyer, H.2    Choi, D.W.3
  • 3
    • 0031443993 scopus 로고    scopus 로고
    • Threshold of metabolic acidosis associated with newborn complications
    • Low JA, Lindsay BG, Derrick EJ. Threshold of metabolic acidosis associated with newborn complications. Am J Obstet Gynecol (1997) 177(6):1391-4. doi:10.1016/S0002-9378(97)70080-2
    • (1997) Am J Obstet Gynecol , vol.177 , Issue.6 , pp. 1391-1394
    • Low, J.A.1    Lindsay, B.G.2    Derrick, E.J.3
  • 4
    • 0018867282 scopus 로고
    • Neonatal asphyxia. I. Relationship of obstetric and neonatal complications to neonatal mortality in 38,405 consecutive deliveries
    • MacDonald HM, Mulligan JC, Allen AC, Taylor PM. Neonatal asphyxia. I. Relationship of obstetric and neonatal complications to neonatal mortality in 38,405 consecutive deliveries. J Pediatr (1980) 96(5):898-902. doi:10.1016/S0022-3476(80)80574-9
    • (1980) J Pediatr , vol.96 , Issue.5 , pp. 898-902
    • MacDonald, H.M.1    Mulligan, J.C.2    Allen, A.C.3    Taylor, P.M.4
  • 5
    • 0019378943 scopus 로고
    • Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome
    • Finer NN, Robertson CM, Richards RT, Pinnell LE, Peters KL. Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome. J Pediatr (1981) 98(1):112-7. doi:10.1016/S0022-3476(81)80555-0
    • (1981) J Pediatr , vol.98 , Issue.1 , pp. 112-117
    • Finer, N.N.1    Robertson, C.M.2    Richards, R.T.3    Pinnell, L.E.4    Peters, K.L.5
  • 6
    • 0024602050 scopus 로고
    • School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term
    • Robertson CM, Finer NN, Grace MG. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr (1989) 114(5):753-60. doi:10.1016/S0022-3476(89)80132-5
    • (1989) J Pediatr , vol.114 , Issue.5 , pp. 753-760
    • Robertson, C.M.1    Finer, N.N.2    Grace, M.G.3
  • 7
    • 0017199855 scopus 로고
    • Neonatal encephalopathy following fetal distress A clinical and electroencephalographic study
    • Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol (1976) 33(10):696-705. doi:10.1001/archneur.1976.00500100030012
    • (1976) Arch Neurol , vol.33 , Issue.10 , pp. 696-705
    • Sarnat, H.B.1    Sarnat, M.S.2
  • 8
    • 34248209089 scopus 로고    scopus 로고
    • Determinants of outcomes after head cooling for neonatal encephalopathy
    • Wyatt JS, Gluckman PD, Liu PY, Azzopardi D, Ballard R, Edwards AD, et al. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics (2007) 119(5):912-21. doi:10.1542/peds.2006-2839
    • (2007) Pediatrics , vol.119 , Issue.5 , pp. 912-921
    • Wyatt, J.S.1    Gluckman, P.D.2    Liu, P.Y.3    Azzopardi, D.4    Ballard, R.5    Edwards, A.D.6
  • 10
    • 84861521265 scopus 로고    scopus 로고
    • Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis
    • Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson DA. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med (2012) 166(6):558-66. doi:10.1001/archpediatrics.2011.1772
    • (2012) Arch Pediatr Adolesc Med , vol.166 , Issue.6 , pp. 558-566
    • Tagin, M.A.1    Woolcott, C.G.2    Vincer, M.J.3    Whyte, R.K.4    Stinson, D.A.5
  • 11
    • 84881310734 scopus 로고    scopus 로고
    • Cooling in the real world: therapeutic hypothermia in hypoxic-ischemic encephalopathy
    • Garfinkle J, Sant'Anna GM, Wintermark P, Ali N, Morneault L, Koclas L, et al. Cooling in the real world: therapeutic hypothermia in hypoxic-ischemic encephalopathy. Eur J Paediatr Neurol (2013) 17(5):492-7. doi:10.1016/j.ejpn.2013.03.006
    • (2013) Eur J Paediatr Neurol , vol.17 , Issue.5 , pp. 492-497
    • Garfinkle, J.1    Sant'Anna, G.M.2    Wintermark, P.3    Ali, N.4    Morneault, L.5    Koclas, L.6
  • 13
    • 41549116819 scopus 로고    scopus 로고
    • Prediction of short-term neurological outcome in full-term neonates with hypoxic-ischaemic encephalopathy based on combined use of electroencephalogram and neuro-imaging
    • Leijser LM, Vein AA, Liauw L, Strauss T, Veen S, Wezel-Meijler Gv. Prediction of short-term neurological outcome in full-term neonates with hypoxic-ischaemic encephalopathy based on combined use of electroencephalogram and neuro-imaging. Neuropediatrics (2007) 38(5):219-27. doi:10.1055/s-2007-992815
    • (2007) Neuropediatrics , vol.38 , Issue.5 , pp. 219-227
    • Leijser, L.M.1    Vein, A.A.2    Liauw, L.3    Strauss, T.4    Veen, S.5    Wezel-Meijler, G.6
  • 15
    • 33744808267 scopus 로고    scopus 로고
    • Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients
    • Boichot C, Walker PM, Durand C, Grimaldi M, Chapuis S, Gouyon JB, et al. Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients. Radiology (2006) 239(3):839-48. doi:10.1148/radiol.2393050027
    • (2006) Radiology , vol.239 , Issue.3 , pp. 839-848
    • Boichot, C.1    Walker, P.M.2    Durand, C.3    Grimaldi, M.4    Chapuis, S.5    Gouyon, J.B.6
  • 16
    • 84872868529 scopus 로고    scopus 로고
    • Prognostic tests in term neonates with hypoxic-ischemic encephalopathy: a systematic review
    • van Laerhoven H, de Haan TR, Offringa M, Post B, van der Lee JH. Prognostic tests in term neonates with hypoxic-ischemic encephalopathy: a systematic review. Pediatrics (2012) 131(1):88-98. doi:10.1542/peds.2012-1297
    • (2012) Pediatrics , vol.131 , Issue.1 , pp. 88-98
    • van Laerhoven, H.1    de Haan, T.R.2    Offringa, M.3    Post, B.4    van der Lee, J.H.5
  • 17
    • 80052548876 scopus 로고    scopus 로고
    • A new neurological focus in neonatal intensive care
    • Bonifacio SL, Glass HC, Peloquin S, Ferriero DM. A new neurological focus in neonatal intensive care. Nat Rev Neurol (2011) 7(9):485-94. doi:10.1038/nrneurol.2011.119
    • (2011) Nat Rev Neurol , vol.7 , Issue.9 , pp. 485-494
    • Bonifacio, S.L.1    Glass, H.C.2    Peloquin, S.3    Ferriero, D.M.4
  • 18
    • 37249042147 scopus 로고    scopus 로고
    • Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy
    • Gunn AJ, Wyatt JS, Whitelaw A, Barks J, Azzopardi D, Ballard R, et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr (2008) 152(1):55-8. doi:10.1016/j.jpeds.2007.06.003
    • (2008) J Pediatr , vol.152 , Issue.1 , pp. 55-58
    • Gunn, A.J.1    Wyatt, J.S.2    Whitelaw, A.3    Barks, J.4    Azzopardi, D.5    Ballard, R.6
  • 19
    • 77954355545 scopus 로고    scopus 로고
    • Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia
    • Thoresen M, Hellström-Westas L, Liu X, de Vries LS. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics (2010) 126(1):e131-9. doi:10.1542/peds.2009-2938
    • (2010) Pediatrics , vol.126 , Issue.1 , pp. e131-e139
    • Thoresen, M.1    Hellström-Westas, L.2    Liu, X.3    de Vries, L.S.4
  • 20
    • 0021849021 scopus 로고
    • Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes
    • Eng LF. Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes. J Neuroimmunol (1985) 8(4-6):203-14. doi:10.1016/S0165-5728(85)80063-1
    • (1985) J Neuroimmunol , vol.8 , Issue.4-6 , pp. 203-214
    • Eng, L.F.1
  • 21
    • 77949272190 scopus 로고    scopus 로고
    • UCHL1 (PGP 9 5): neuronal biomarker and ubiquitin system protein
    • Day IN, Thompson RJ. UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein. Prog Neurobiol (2009) 90(3):327-62. doi:10.1016/j.pneurobio.2009.10.020
    • (2009) Prog Neurobiol , vol.90 , Issue.3 , pp. 327-362
    • Day, I.N.1    Thompson, R.J.2
  • 22
    • 77049106939 scopus 로고    scopus 로고
    • Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats
    • Liu MC, Akinyi L, Scharf D, Mo J, Larner SF, Muller U, et al. Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats. Eur J Neurosci (2010) 31(4):722-32. doi:10.1111/j.1460-9568.2010.07097.x
    • (2010) Eur J Neurosci , vol.31 , Issue.4 , pp. 722-732
    • Liu, M.C.1    Akinyi, L.2    Scharf, D.3    Mo, J.4    Larner, S.F.5    Muller, U.6
  • 23
    • 84865853598 scopus 로고    scopus 로고
    • Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury
    • Mondello S, Linnet A, Buki A, Robicsek S, Gabrielli A, Tepas J, et al. Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury. Neurosurgery (2011) 70(3):666-75. doi:10.1227/NEU.0b013e318236a809
    • (2011) Neurosurgery , vol.70 , Issue.3 , pp. 666-675
    • Mondello, S.1    Linnet, A.2    Buki, A.3    Robicsek, S.4    Gabrielli, A.5    Tepas, J.6
  • 24
    • 74049143794 scopus 로고    scopus 로고
    • Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury
    • Papa L, Akinyi L, Liu MC, Pineda JA, Tepas JJ III, Oli MW, et al. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med (2009) 38(1):138-44. doi:10.1097/CCM.0b013e3181b788ab
    • (2009) Crit Care Med , vol.38 , Issue.1 , pp. 138-144
    • Papa, L.1    Akinyi, L.2    Liu, M.C.3    Pineda, J.A.4    Tepas, J.J.5    Oli, M.W.6
  • 25
    • 84861531178 scopus 로고    scopus 로고
    • Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention
    • Papa L, Lewis LM, Falk JL, Zhang Z, Silvestri S, Giordano P, et al. Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Ann Emerg Med (2011) 59(6):471-83. doi:10.1016/j.annemergmed.2011.08.021
    • (2011) Ann Emerg Med , vol.59 , Issue.6 , pp. 471-483
    • Papa, L.1    Lewis, L.M.2    Falk, J.L.3    Zhang, Z.4    Silvestri, S.5    Giordano, P.6
  • 26
    • 84864567402 scopus 로고    scopus 로고
    • Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention
    • Papa L, Lewis LM, Silvestri S, Falk JL, Giordano P, Brophy GM, et al. Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention. J Trauma Acute Care Surg (2012) 72(5):1335-44. doi:10.1097/TA.0b013e3182491e3d
    • (2012) J Trauma Acute Care Surg , vol.72 , Issue.5 , pp. 1335-1344
    • Papa, L.1    Lewis, L.M.2    Silvestri, S.3    Falk, J.L.4    Giordano, P.5    Brophy, G.M.6
  • 27
    • 84861970101 scopus 로고    scopus 로고
    • Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator
    • Czeiter E, Mondello S, Kovacs N, Sandor J, Gabrielli A, Schmid K, et al. Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator. J Neurotrauma (2012) 29(9):1770-8. doi:10.1089/neu.2011.2127
    • (2012) J Neurotrauma , vol.29 , Issue.9 , pp. 1770-1778
    • Czeiter, E.1    Mondello, S.2    Kovacs, N.3    Sandor, J.4    Gabrielli, A.5    Schmid, K.6
  • 28
    • 79959727775 scopus 로고    scopus 로고
    • Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids
    • Brophy GM, Mondello S, Papa L, Robicsek SA, Gabrielli A, Tepas J3rd, et al. Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids. J Neurotrauma (2011) 28(6):861-70. doi:10.1089/neu.2010.1564
    • (2011) J Neurotrauma , vol.28 , Issue.6 , pp. 861-870
    • Brophy, G.M.1    Mondello, S.2    Papa, L.3    Robicsek, S.A.4    Gabrielli, A.5    Tepas, J.6
  • 29
    • 80052271909 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling
    • Ennen CS, Huisman TA, Savage WJ, Northington FJ, Jennings JM, Everett AD, et al. Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling. Am J Obstet Gynecol (2011) 205(3):e1-7. doi:10.1016/j.ajog.2011.06.025
    • (2011) Am J Obstet Gynecol , vol.205 , Issue.3 , pp. e1-e7
    • Ennen, C.S.1    Huisman, T.A.2    Savage, W.J.3    Northington, F.J.4    Jennings, J.M.5    Everett, A.D.6
  • 30
    • 84865420593 scopus 로고    scopus 로고
    • Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure
    • Mondello S, Palmio J, Streeter J, Hayes RL, Peltola J, Jeromin A. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure. BMC Neurol (2012) 12(1):85. doi:10.1186/1471-2377-12-85
    • (2012) BMC Neurol , vol.12 , Issue.1 , pp. 85
    • Mondello, S.1    Palmio, J.2    Streeter, J.3    Hayes, R.L.4    Peltola, J.5    Jeromin, A.6
  • 31
    • 84892745672 scopus 로고    scopus 로고
    • Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP)
    • Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, et al. Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP). J Neurotrauma (2014) 31(1):19-25. doi:10.1089/neu.2013.3040
    • (2014) J Neurotrauma , vol.31 , Issue.1 , pp. 19-25
    • Diaz-Arrastia, R.1    Wang, K.K.2    Papa, L.3    Sorani, M.D.4    Yue, J.K.5    Puccio, A.M.6
  • 32
    • 84882623948 scopus 로고    scopus 로고
    • GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study
    • Okonkwo DO, Yue JK, Puccio AM, Panczykowski DM, Inoue T, McMahon PJ, et al. GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma (2013) 30(17):1490-7. doi:10.1089/neu.2013.2883
    • (2013) J Neurotrauma , vol.30 , Issue.17 , pp. 1490-1497
    • Okonkwo, D.O.1    Yue, J.K.2    Puccio, A.M.3    Panczykowski, D.M.4    Inoue, T.5    McMahon, P.J.6
  • 33
    • 84863937903 scopus 로고    scopus 로고
    • Characterization of antibodies that detect human GFAP after traumatic brain injury
    • Zoltewicz JS, Scharf D, Yang B, Chawla A, Newsom KJ, Fang L. Characterization of antibodies that detect human GFAP after traumatic brain injury. Biomark Insights (2012) 7:71-9. doi:10.4137/BMI.S9873
    • (2012) Biomark Insights , vol.7 , pp. 71-79
    • Zoltewicz, J.S.1    Scharf, D.2    Yang, B.3    Chawla, A.4    Newsom, K.J.5    Fang, L.6
  • 36
    • 0021027748 scopus 로고
    • Thompson RJ, Doran JF, Jackson P, Dhillon AP, Rode J. PGP 9.5 - a new marker for vertebrate neurons and neuroendocrine cells. Brain Res (1983) 278(1-2):224-8. doi:10.1016/0006-8993(83)90241-X
    • (1983) Brain Res , vol.278 , Issue.1-2 , pp. 224-228
    • Thompson, R.J.1    Doran, J.F.2    Jackson, P.3    Dhillon, A.P.4
  • 37
    • 44349123834 scopus 로고    scopus 로고
    • Detection of phosphorylated NF-H in the cerebrospinal fluid and blood of aneurysmal subarachnoid hemorrhage patients
    • Lewis SB, Wolper RA, Miralia L, Yang C, Shaw G. Detection of phosphorylated NF-H in the cerebrospinal fluid and blood of aneurysmal subarachnoid hemorrhage patients. J Cereb Blood Flow Metab (2008) 28(6):1261-71. doi:10.1038/jcbfm.2008.12
    • (2008) J Cereb Blood Flow Metab , vol.28 , Issue.6 , pp. 1261-1271
    • Lewis, S.B.1    Wolper, R.A.2    Miralia, L.3    Yang, C.4    Shaw, G.5
  • 38
    • 84874942659 scopus 로고    scopus 로고
    • Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study
    • Massaro AN, Jeromin A, Kadom N, Vezina G, Hayes RL, Wang KK, et al. Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study. Pediatr Crit Care Med (2013) 14(3):310-7. doi:10.1097/PCC.0b013e3182720642
    • (2013) Pediatr Crit Care Med , vol.14 , Issue.3 , pp. 310-317
    • Massaro, A.N.1    Jeromin, A.2    Kadom, N.3    Vezina, G.4    Hayes, R.L.5    Wang, K.K.6
  • 39
    • 79959853430 scopus 로고    scopus 로고
    • Elevated serum ubiquitin carboxy-terminal hydrolase L1 is associated with abnormal blood-brain barrier function after traumatic brain injury
    • Blyth BJ, Farahvar A, He H, Nayak A, Yang C, Shaw G, et al. Elevated serum ubiquitin carboxy-terminal hydrolase L1 is associated with abnormal blood-brain barrier function after traumatic brain injury. J Neurotrauma (2011) 28(12):2453-62. doi:10.1089/neu.2010.1653
    • (2011) J Neurotrauma , vol.28 , Issue.12 , pp. 2453-2462
    • Blyth, B.J.1    Farahvar, A.2    He, H.3    Nayak, A.4    Yang, C.5    Shaw, G.6
  • 40
    • 51649124497 scopus 로고    scopus 로고
    • Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy
    • Kumar A, Mittal R, Khanna HD, Basu S. Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy. Pediatrics (2008) 122(3):e722-7. doi:10.1542/peds.2008-0269
    • (2008) Pediatrics , vol.122 , Issue.3 , pp. e722-e727
    • Kumar, A.1    Mittal, R.2    Khanna, H.D.3    Basu, S.4
  • 41
    • 84874558259 scopus 로고    scopus 로고
    • Biomarkers of brain injury in the premature infant
    • Douglas-Escobar M, Weiss MD. Biomarkers of brain injury in the premature infant. Front Neurol (2012) 3:185. doi:10.3389/fneur.2012.00185
    • (2012) Front Neurol , vol.3 , pp. 185
    • Douglas-Escobar, M.1    Weiss, M.D.2
  • 42
    • 84894352084 scopus 로고    scopus 로고
    • Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy
    • Chalak LF, Sánchez PJ, Adams-Huet B, Laptook AR, Heyne RJ, Rosenfeld CR. Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy. J Pediatr (2014) 164(3):468-474e1. doi:10.1016/j.jpeds.2013.10.067
    • (2014) J Pediatr , vol.164 , Issue.3 , pp. 468-474e1
    • Chalak, L.F.1    Sánchez, P.J.2    Adams-Huet, B.3    Laptook, A.R.4    Heyne, R.J.5    Rosenfeld, C.R.6
  • 43
    • 84870947198 scopus 로고    scopus 로고
    • Biomarkers of hypoxic-ischemic encephalopathy in newborns
    • Douglas-Escobar M, Weiss MD. Biomarkers of hypoxic-ischemic encephalopathy in newborns. Front Neurol (2012) 3:144. doi:10.3389/fneur.2012.00144
    • (2012) Front Neurol , vol.3 , pp. 144
    • Douglas-Escobar, M.1    Weiss, M.D.2


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