Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: A pilot study

Pediatric Critical Care Medicine

Volumn 14, Issue 3, 2013, Pages 310-317

  Massaro, An N ^a   Jeromin, Andreas ^b   Kadom, Nadja ^a   Vezina, Gilbert ^a   Hayes, Ronald L ^b   Wang, Kevin K W ^b   Streeter, Jackson ^b   Johnston, Michael V ^c  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b Banyan Biomarkers   (United States)

^c KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

asphyxia; biomarker; hypoxic ischemic encephalopathy; neonate; therapeutic hypothermia

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; UBIQUITIN THIOLESTERASE;

ARTICLE; BRAIN INJURY; CLINICAL ARTICLE; DISEASE SEVERITY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; INTENSIVE CARE UNIT; MALE; NEWBORN; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIATION INJURY;

BIOLOGICAL MARKERS; BRAIN INJURIES; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MALE; PILOT PROJECTS; PROSPECTIVE STUDIES; ROC CURVE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; UBIQUITIN THIOLESTERASE;

EID: 84874942659     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3182720642     Document Type: Article

References (44)

1. Shankaran S, Woldt E, Koepke T, et al: Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev 1991; 25:135-148
2. Dilenge ME, Majnemer A, Shevell MI: Long-term developmental outcome of asphyxiated term neonates. J Child Neurol 2001; 16:781-792
3. Azzopardi DV, Strohm B, Edwards AD, et al: Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009; 361:1349-1358
4. Shankaran S, Laptook AR, Ehrenkranz RA, et al: Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353:1574-1584
5. Gluckman PD, Wyatt JS, Azzopardi D, et al: Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial. Lancet 2005; 365:663-670
6. Ramaswamy V, Horton J, Vandermeer B, et al: Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatr Neurol 2009; 40:215-226
7. Wilkinson KD, Lee KM, Deshpande S, et al: The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science 1989; 246:670-673
8. Lewis SB, Wolper R, Chi YY, et al: Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage. J Neurosci Res 2010; 88:1475-1484
9. Papa L, Akinyi L, Liu MC, et al: Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med 2010; 38:138-144
10. Siman R, Toraskar N, Dang A, et al: A panel of neuron-enriched proteins as markers for traumatic brain injury in humans. J Neurotrauma 2009; 26:1867-1877
11. Siman R, Roberts VL, McNeil E, et al: Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. Brain Res 2008; 1213:1-11
12. Arnaoutakis GJ, George TJ, Wang KK, et al: Serum levels of neuronspecific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest. J Thorac Cardiovasc Surg 2011; 142:902-910.e1
13. Eng LF, Vanderhaeghen JJ, Bignami A, et al: An acidic protein isolated from fibrous astrocytes. Brain Res 1971; 28:351-354
14. Eng LF, Ghirnikar RS, Lee YL: Glial fibrillary acidic protein: GFAPthirty-one years (1969-2000). Neurochem Res 2000; 25:1439-1451
15. Lumpkins KM, Bochicchio GV, Keledjian K, et al: Glial fibrillary acidic protein is highly correlated with brain injury. J Trauma 2008; 65:778-782
16. Honda M, Tsuruta R, Kaneko T, et al: Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. J Trauma 2010; 69:104-109
17. Kaneko T, Kasaoka S, Miyauchi T, et al: Serum glial fibrillary acidic protein as a predictive biomarker of neurological outcome after cardiac arrest. Resuscitation 2009; 80:790-794
18. Bembea MM, Savage W, Strouse JJ, et al: Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Care Med 2011; 12:572-579
19. Douglas-Escobar M, Yang C, Bennett J, et al: A pilot study of novel biomarkers in neonates with hypoxic-ischemic encephalopathy. Pediatr Res 2010; 68:531-536
20. Ennen CS, Huisman TA, Savage WJ, et al: Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling. Am J Obstet Gynecol 2011; 205:251.e1-251.e7
21. Liu MC, Akinyi L, Scharf D, et al: Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats. Eur J Neurosci 2010; 31:722-732
22. Barkovich AJ, Hajnal BL, Vigneron D, et al: Prediction of neuromotor outcome in perinatal asphyxia: Evaluation of MR scoring systems. AJNR Am J Neuroradiol 1998; 19:143-149
23. Sarnat HB, Sarnat MS: Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976; 33:696-705
24. Miller SP, Ramaswamy V, Michelson D, et al: Patterns of brain injury in term neonatal encephalopathy. J Pediatr 2005; 146:453-460
25. Holmes G, Rowe J, Hafford J, et al: Prognostic value of the electroencephalogram in neonatal asphyxia. Electroencephalogr Clin Neurophysiol 1982; 53:60-72
26. Obrecht R, Pollock MA, Evans S, et al: Prediction of outcome in neonates using EEG. Clin Electroencephalogr 1982; 13:46-49
27. Aly H, Khashaba MT, El-Ayouty M, et al: IL-1beta, IL-6 and TNF-alpha and outcomes of neonatal hypoxic ischemic encephalopathy. Brain Dev 2006; 28:178-182
28. Bartha AI, Foster-Barber A, Miller SP, et al: Neonatal encephalopathy: Association of cytokines with MR spectroscopy and outcome. Pediatr Res 2004; 56:960-966
29. Sävman K, Blennow M, Gustafson K, et al: Cytokine response in cerebrospinal fluid after birth asphyxia. Pediatr Res 1998; 43:746-751
30. Huang CC, Wang ST, Chang YC, et al: Measurement of the urinary lactate:creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy. N Engl J Med 1999; 341:328-335
31. Dellenbach P, Haberey P: Lactate as indicator for fetal and neonatal asphyxia. Lancet 1982; 1:907
32. Dorrepaal CA, Berger HM, Benders MJ, et al: Nonprotein-bound iron in postasphyxial reperfusion injury of the newborn. Pediatrics 1996; 98:883-889
33. Nagdyman N, Grimmer I, Scholz T, et al: Predictive value of brainspecific proteins in serum for neurodevelopmental outcome after birth asphyxia. Pediatr Res 2003; 54:270-275
34. Blennow M, Sävman K, Ilves P, et al: Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants. Acta Paediatr 2001; 90:1171-1175
35. Tekgul H, Yalaz M, Kutukculer N, et al: Value of biochemical markers for outcome in term infants with asphyxia. Pediatr Neurol 2004; 31:326-332
36. Thorngren-Jerneck K, Alling C, Herbst A, et al: S100 protein in serum as a prognostic marker for cerebral injury in term newborn infants with hypoxic ischemic encephalopathy. Pediatr Res 2004; 55:406-412
37. Massaro AN CT, Kadom N, Tsuchida T, et al: Biomarkers of brain injury in neonatal encephalopathy treated with hypothermia. J Pediatr 2012; 161:434-440
38. Valentim LM, Michalowski CB, Gottardo SP, et al: Effects of transient cerebral ischemia on glial fibrillary acidic protein phosphorylation and immunocontent in rat hippocampus. Neuroscience 1999; 91:1291-1297
39. Bidmon HJ, Jancsik V, Schleicher A, et al: Structural alterations and changes in cytoskeletal proteins and proteoglycans after focal cortical ischemia. Neuroscience 1998; 82:397-420
40. Ambalavanan N, Carlo WA, Shankaran S, et al: Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics 2006; 118:2084-2093
41. Wyatt JS, Gluckman PD, Liu PY, et al: Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics 2007; 119:912-921
42. Gunn AJ, Wyatt JS, Whitelaw A, et al: Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr 2008; 152:55-8, 58.e1
43. Rutherford M, Ramenghi LA, Edwards AD, et al: Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxicischaemic encephalopathy: A nested substudy of a randomised controlled trial. Lancet Neurol 2010; 9:39-45
44. Higgins RD, Raju T, Edwards AD, et al: Hypothermia and other treatment options for neonatal encephalopathy: An executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr 2011; 159:851-858.e1