Cadmium transporters in the kidney and cadmium-induced nephrotoxicity

International Journal of Molecular Sciences

Volumn 16, Issue 1, 2015, Pages 1484-1494

  Yang, Hong ^a   Shu, Yan ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Cadmium; Nephrotoxicity; Transporter

Indexed keywords

ACETYLCYSTEINE; CADMIUM TRANSPORTER; CALCIUM TRANSPORTER; CYSTEINE; GLUTATHIONE; HOMOCYSTEINE; MEMBRANE PROTEIN; METALLOTHIONEIN; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 2; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; ORGANIC CATION TRANSPORTER; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; ZINC TRANSPORTER; CADMIUM; CALCIUM CHANNEL; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; ZINC-BINDING PROTEIN;

CADMIUM INDUCED NEPHROTOXICITY; CADMIUM POISONING; CADMIUM TRANSPORT; HUMAN; MEMBRANE TRANSPORT; NONHUMAN; POLLUTANT; REVIEW; ZINC TRANSPORT; DRUG EFFECTS; ION TRANSPORT; KIDNEY; METABOLISM;

CADMIUM; CALCIUM CHANNELS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; HUMANS; ION TRANSPORT; KIDNEY; METALLOTHIONEIN; ORGANIC CATION TRANSPORT PROTEINS;

EID: 84920973478     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16011484     Document Type: Review

References (39)

1. Liu, J.; Qu, W.; Kadiiska, M.B. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol. Appl. Pharmacol. 2009, 238, 209–214.
2. Rani, A.; Kumar, A.; Lal, A.; Pant, M. Cellular mechanisms of cadmium-induced toxicity: A review. Int. J. Environ. Health Res. 2014, 24, 378–399.
3. Thevenod, F.; Lee, W.K. Cadmium and cellular signaling cascades: Interactions between cell death and survival pathways. Arch. Toxicol. 2013, 87, 1743–1786.
4. Yang, H.; Shu, Y. University of Maryland at Baltimore, Baltimore City, MD. Unpublished work, 2015.
5. Klaassen, D.C.; Liu, J.; Choudhuri, S. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 1999, 39, 267–294.
6. Kagi, J.H.; Valee, B.L. Metallothionein: A cadmium- and zinc-containing protein from equine renal cortex. J. Biol. Chem. 1960, 235, 3460–3465.
7. Dudley, E.R.; Gammal, L.M.; Klaassen, C.D. Cadmium-induced hepatic and renal injury in chronically exposed rats: Likely role of hepatic cadmium-metallothionein in nephrotoxicity. Toxicol. Appl. Pharmacol. 1985, 77, 414–426.
8. Zalups, R.K.; Ahmad, S. Molecular handling of cadmium in transporting epithelia. Toxicol. Appl. Pharmacol. 2003, 186, 163–188.
9. Chan, H.M.; Zhu, L.F.; Zhong, R.; Grant, D.; Goyer, R.A.; Cherian, M.G. Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol. Appl. Pharmacol. 1993, 123, 89–96.
10. Liu, Y.; Liu, J.; Habeebu, S.M.; Waalkes, M.P.; Klaassen, C.D. Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicol. Sci. 2000, 57, 167–176.
11. Dorian, C.; Gattone, V.H.,II.; Klaassen, C.D. Accumulation and degradation of the protein moiety of cadmium-metallothionein (CdMT) in the mouse kidney. Toxicol. Appl. Pharmacol. 1992, 117, 242–248.
12. Liu, J.; Liu, Y.; Habeebu, S.S.; Klaassen, C.D. Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. Toxicol. Sci. 1998, 46, 197–203.
13. Jenkitkasemwong, S.; Wang, C. Y.; Mackenzie, B.; Knutson, M. D. Physiologic implications of metal-ion transport by ZIP14 and ZIP 8. Biometals 2012, 25, 643–655.
14. Fujishiro, H.; Yano, Y.; Takada, Y.; Tanihara, M.; Himeno, S. Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. Metallomics 2012, 4, 700–708.
15. Martin, P.; Boulukos, K.E.; Poggi, M.C.; Pognonec, P. Long-term extracellular signal-related kinase activation following cadmium intoxication is negatively regulated by a protein kinase C-dependent pathway affecting cadmium transport. FEBS J. 2009, 276, 1667–1679.
16. Fujishiro, H.; Doi, M.; Enomoto, S.; Himeno, S. High sensitivity of RBL-2H3 cells to cadmium and manganese: An implication of the role of ZIP 8. Metallomics 2011, 3, 710–718.
17. Fujishiro, H.; Ohashi, T.; Takuma, M.; Himeno, S. Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells. Metallomics 2013, 5, 437–444.
18. Barbier, O.; Jacquillet, G.; Tauc, M.; Poujeol, P.; Cougnon, M. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. Am. J. Physiol. Renal. Physiol. 2004, 287, F1067–F1075.
19. Tang, W.; Sadovic, S.; Shaikh, Z.A. Nephrotoxicity of cadmium-metallothionein: Protection by zinc and role of glutathione. Toxicol. Appl. Pharmacol. 1998, 151, 276–282.
20. Agirdir, B.V.; Bilgen, I.; Dinc, O.; Ozcaglar, H.U.; Fisenk, F.; Turhan, M.; Oner, G. Effect of zinc ion on cadmium-induced auditory changes. Biol. Trace Elem. Res. 2002, 88, 153–163.
21. Jacquillet, G.; Barbier, O.; Cougnon, M.; Tauc, M.; Namorado, M.C.; Martin, D.; Reyes, J.L.; Poujeol, P. Zinc protects renal function during cadmium intoxication in the rat. Am. J. Physiol. Renal. Physiol. 2006, 290, F127–F137.
22. Rentschler, G.; Kippler, M.; Axmon, A.; Raqib, R.; Skerfving, S.; Vahter, M.; Broberg, K. Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes. Metallomics 2014, 6, 885–891.
23. Lin, Y.S.; Ho, W.C.; Caffrey, J.L.; Sonawane, B. Low serum zinc is associated with elevated risk of cadmium nephrotoxicity. Environ. Res. 2014, 134C, 33–38.
24. Wang, Y.; Zalups, R.K.; Barfuss, D.W. Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules. Toxicol. Lett. 2010, 193, 61–68.
25. Kovacs, G.; Montalbetti, N.; Franz, M.C.; Graeter, S.; Simonin, A.; Hediger, M.A. Human TRPV5 and TRPV6: Key players in cadmium and zinc toxicity. Cell Calcium 2013, 54, 276–286.
26. Kovacs, G.; Danko, T.; Bergeron, M.J.; Balazs, B.; Suzuki, Y.; Zsembery, A.; Hediger, M.A. Heavy metal cations permeate the TRPV6 epithelial cation channel. Cell Calcium 2011, 49, 43–55.
27. Marchetti, C. Role of calcium channels in heavy metal toxicity. ISRN Toxicol. 2013, 2013, 184360.
28. Bannon, D.I.; Abounader, R.; Lees, P.S.; Bressler, J.P. Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells. Am. J. Physiol. Cell Physiol. 2003, 284, C44–C50.
29. Fujishiro, H.; Kubota, K.; Inoue, D.; Inoue, A.; Yanagiya, T.; Enomoto, S.; Himeno, S. Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese. Toxicology 2011, 280, 118–125.
30. Illing, A.C.; Shawki, A.; Cunningham, C.L.; Mackenzie, B. Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1. J. Biol. Chem. 2012, 287, 30485–30496.
31. Hiratsuka, H.; Katsuta, O.; Toyota, N.; Tsuchitani, M.; Umemura, T.; Marumo, F. Chronic cadmium exposure-induced renal anemia in ovariectomized rats. Toxicol. Appl. Pharmacol. 1996, 137, 228–236.
32. Kim, D.W.; Kim, K.Y.; Choi, B.S.; Youn, P.; Ryu, D.Y.; Klaassen, C.D.; Park, J.D. Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake. Arch. Toxicol. 2007, 81, 327–334.
33. Morrissey, K.M.; Stocker, S.L.; Wittwer, M.B.; Xu, L.; Giacomini, K.M. Renal transporters in drug development. Annu. Rev. Pharmacol. Toxicol. 2013, 53, 503–529.
34. Soodvilai, S.; Nantavishit, J.; Muanprasat, C.; Chatsudthipong, V. Renal organic cation transporters mediated cadmium-induced nephrotoxicity. Toxicol. Lett. 2011, 204, 38–42.
35. Zalups, R. K. Evidence for basolateral uptake of cadmium in the kidneys of rats. Toxicol. Appl. Pharmacol. 2000, 164, 15–23.
36. Shaikh, A.Z.; Northup, J.B.; Vestergaard, P. Dependence of cadmium-metallothionein nephrotoxicity on glutathione. J. Toxicol. Environ. Health. A 1999, 57, 211–222.
37. Kimura, O.; Endo, T.; Hotta, Y.; Sakata, M. Effects of P-glycoprotein inhibitors on transepithelial transport of cadmium in cultured renal epithelial cells, LLC-PK1 and LLC-GA5-COL 150. Toxicology 2005, 208, 123–132.
38. Lee, W.K.; Torchalski, B.; Kohistani, N.; Thevenod, F. ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: Roles of cadmium and ceramide transport. Toxicol. Sci. 2011, 121, 343–356.
39. Martin, P.; Fareh, M.; Poggi, M.C.; Boulukos, K.E.; Pognonec, P. Manganese is highly effective in protecting cells from cadmium intoxication. Biochem. Biophys. Res. Commun. 2006, 351, 294–299.