Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules

Toxicology Letters

Volumn 193, Issue 1, 2010, Pages 61-68

  Wang, Yanhua ^a   Zalups, Rudolfs K ^b   Barfuss, Delon W ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cadmium transport; Calcium transporters; Divalent cation transporter 1; Molecular mimicry; Proximal tubule; Zinc transporters

Indexed keywords

ARGININE; ASPARTIC ACID; CADMIUM; CALCIUM ION; CYSTEINE; CYSTINE; GLUTAMIC ACID; HOMOCYSTEINE; IRON; METHIONINE; THIOL; ZINC ION;

ACUTE TOXICITY; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY; TOXICITY TESTING;

ABSORPTION; ANIMALS; ARGININE; CADMIUM; CALCIUM; CELLS, CULTURED; CYSTINE; FEMALE; HOMOCYSTEINE; IRON; KIDNEY TUBULES, PROXIMAL; PERFUSION; RABBITS; TEMPERATURE; ZINC;

ORYCTOLAGUS CUNICULUS;

EID: 75749103651     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.12.007     Document Type: Article

References (30)

1. Barbier O., Jacquillet G., Tauc M., Poujeol P., and Cougnon M. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. Am. J. Physiol. Renal Physiol. 287 (2004) F1067-F1075
2. Beech D.J. TRPC1: store-operated channel and more. Pflugers Arch. 451 (2005) 53-60
3. Blazka M.E., and Shaikh Z.A. Differences in cadmium and mercury uptakes by hepatocytes: role of calcium channels. Toxicol. Appl. Pharmacol. 110 (1991) 355-363
4. Bridges C.C., Bauch C., Verrey F., and Zalups R.K. Mercuric conjugates of cysteine are transported by the amino acid transporter system b(0,+): implications of molecular mimicry. J. Am. Soc. Nephrol. 15 (2004) 663-673
5. Bridges C.C., and Zalups R.K. Homocysteine, system b0,+ and the renal epithelial transport and toxicity of inorganic mercury. Am. J. Pathol. 165 (2004) 1385-1394
6. Cannon V.T., Zalups R.K., and Barfuss D.W. Amino acid transporters involved in luminal transport of mercuric conjugates of cysteine in rabbit proximal tubule. J. Pharmacol. Exp. Ther. 298 (2001) 780-789
7. Canonne-Hergaux F., and Gros P. Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int. 62 (2002) 147-156
8. Cragg R.A., Christie G.R., Phillips S.R., Russi R.M., Kury S., Mathers J.C., Taylor P.M., and Ford D. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. J. Biol. Chem. 277 (2002) 22789-22797
9. Felley-Bosco E., and Diezi J. Fate of cadmium in rat renal tubules: a microinjection study. Toxicol. Appl. Pharmacol. 91 (1987) 204-211
10. Ferguson C.J., Wareing M., Ward D.T., Green R., Smith C.P., and Riccardi D. Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am. J. Physiol. Renal Physiol. 280 (2001) F803-814
11. Fromter E., and Gessner K. Free-flow potential profile along rat kidney proximal tubule. Pflugers Arch. 351 (1974) 69-83
12. Furriols M., Chillaron J., Mora C., Castello A., Bertran J., Camps M., Testar X., Vilaro S., Zorzano A., and Palacin M. rBAT, related to l-cysteine transport, is localized to the microvilli of proximal straight tubules, and its expression is regulated in kidney by development. J. Biol. Chem. 268 (1993) 27060-27068
13. Girijashanker K., He L., Soleimani M., Reed J.M., Li H., Liu Z., Wang B., Dalton T.P., and Nebert D.W. Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Mol. Pharmacol. 73 (2008) 1413-1423
14. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
15. He L., Girijashanker K., Dalton T.P., Reed J., Li H., Soleimani M., and Nebert D.W. ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Mol. Pharmacol. 70 (2006) 171-180
16. Ishido M., Suzuki T., Adachi T., and Kunimoto M. Zinc stimulates DNA synthesis during its antiapoptotic action independently with increments of an antiapoptotic protein, Bcl-2, in porcine kidney LLC-PK(1) cells. J. Pharmacol. Exp. Ther. 290 (1999) 923-928
17. Jacquillet G., Barbier O., Cougnon M., Tauc M., Namorado M.C., Martin D., Reyes J.L., and Poujeol P. Zinc protects renal function during cadmium intoxication in the rat. Am. J. Physiol. Renal Physiol. 290 (2006) F127-137
18. Lucis O.J., and Lucis R. Distribution of cadmium 109 and zinc 65 in mice of inbred strains. Arch. Environ. Health 19 (1969) 334-336
19. Mora C., Chillaron J., Calonge M.J., Forgo J., Testar X., Nunes V., Murer H., Zorzano A., and Palacin M. The rBAT gene is responsible for l-cystine uptake via the b0,(+)-like amino acid transport system in a "renal proximal tubular" cell line (OK cells). J. Biol. Chem. 271 (1996) 10569-10576
20. Okubo M., Yamada K., Hosoyamada M., Shibasaki T., and Endou H. Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes. Toxicol. Appl. Pharmacol. 187 (2003) 162-167
21. Olivi L., Sisk J., and Bressler J. Involvement of DMT1 in uptake of Cd in MDCK cells: role of protein kinase C. Am. J. Physiol. Cell Physiol. 281 (2001) C793-800
22. Palacin M., Nunes V., Font-Llitjos M., Jimenez-Vidal M., Fort J., Gasol E., Pineda M., Feliubadalo L., Chillaron J., and Zorzano A. The genetics of heteromeric amino acid transporters. Physiology (Bethesda) 20 (2005) 112-124
23. Piersol M.C., Sterling K.M., and Ahearn G.A. Absorption of tetraethylammonium (TEA+) by perfused lobster intestine. J. Exp. Zool. Part A: Ecol. Genet. Physiol. 307 (2007) 176-186
24. Robinson M.K., Barfuss D.W., and Zalups R.K. Cadmium transport and toxicity in isolated perfused segments of the renal proximal tubule. Toxicol. Appl. Pharmacol. 121 (1993) 103-111
25. Schafer J.A., and Barfuss D.W. Membrane mechanisms for transepithelial amino acid absorption and secretion. Am. J. Physiol. 238 (1980) F335-346
26. Wang B., Schneider S.N., Dragin N., Girijashanker K., Dalton T.P., He L., Miller M.L., Stringer K.F., Soleimani M., Richardson D.D., and Nebert D.W. Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. Am. J. Physiol. Cell Physiol. 292 (2007) C1523-1535
27. Zalups R.K. Evidence for basolateral uptake of cadmium in the kidneys of rats. Toxicol. Appl. Pharmacol. 164 (2000) 15-23
28. Zalups R.K., and Ahmad S. Molecular handling of cadmium in transporting epithelia. Toxicol. Appl. Pharmacol. 186 (2003) 163-188
29. Zalups R.K., and Barfuss D.W. Transport and toxicity of methylmercury along the proximal tubule of the rabbit. Toxicol. Appl. Pharmacol. 121 (1993) 176-185
30. Zhang M.I., and O'Neil R.G. Regulated calcium channel in apical membranes renal proximal tubule cells. Am. J. Physiol. 271 (1996) C1757-1764