Shared intermediate phenotypes for schizophrenia and bipolar disorder: Neuroanatomical features of subtypes distinguished by executive dysfunction

Journal of Psychiatry and Neuroscience

Volumn 40, Issue 1, 2015, Pages 58-68

  Shepherd, Alana M ^a,b   Quidé, Yann ^b   Laurens, Kristin R ^a,b,c   O’Reilly, Nicole ^a   Rowland, Jesseca E ^a   Mitchell, Philip B ^a,d   Vaughan, Carr J ^b   Green, Melissa J ^a,b,d,e  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d BLACK DOG INSTITUTE   (Australia)

^e NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMNESIA; ANGULAR GYRUS; ARTICLE; BIPOLAR I DISORDER; BRAIN SIZE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; FUNCTIONAL DISSOCIATION; GRAY MATTER; HIPPOCAMPUS; HUMAN; IMAGE PROCESSING; INFERIOR FRONTAL GYRUS; MAJOR CLINICAL STUDY; MALE; MIDDLE FRONTAL GYRUS; NEGATIVE SYNDROME; NUCLEAR MAGNETIC RESONANCE IMAGING; ORBITAL CORTEX; PHENOTYPE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRECUNEUS; PRIMARY MOTOR CORTEX; SCHIZOPHRENIA; SUPERIOR FRONTAL GYRUS; TASK PERFORMANCE; WECHSLER INTELLIGENCE SCALE; WHITE MATTER; BIPOLAR DISORDER; BRAIN; COMPARATIVE STUDY; EXECUTIVE FUNCTION; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; PSYCHOLOGY;

ADULT; BIPOLAR DISORDER; BRAIN; EXECUTIVE FUNCTION; FEMALE; GRAY MATTER; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE; PHENOTYPE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; WHITE MATTER;

EID: 84920973347     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.130283     Document Type: Article

References (82)

1. Lichtenstein P, Yip BH, Björk C, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009;373:234-9.
2. Ivleva EI, Morris DW, Moates AF, et al. Genetics and intermediate phenotypes of the schizophrenia–bipolar disorder boundary. Neurosci Biobehav Rev 2010;34:897-921.
3. Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013;45:984-94.
4. Purcell SM, Wray NR, Stone JL, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009;460:748-52.
5. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011;43:969-76.
6. Insel T, Cuthbert B, Garvey M, et al. Research Domain Criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry 2010;167:748-51.
7. Buckholtz JW, Meyer-Lindenberg A. Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness. Neuron 2012;74:990-1004.
8. Bora E, Yucel M, Pantelis C. Cognitive functioning in schizophrenia, schizoaffective disorder and affective psychoses: meta-analytic study. Br J Psychiatry 2009;195:475-82.
9. Ivleva EI, Morris DW, Osuji J, et al. Cognitive endophenotypes of psychosis within dimension and diagnosis. Psychiatry Res 2012;196:38-44.
10. De Peri L, Crescini A, Deste G, et al. Brain structural abnormalities at the onset of schizophrenia and bipolar disorder: a meta-analysis of controlled magnetic resonance imaging studies. Curr Pharm Des 2012;18:486-94.
11. Molina V, Galindo G, Cortés B, et al. Different gray matter patterns in chronic schizophrenia and chronic bipolar disorder patients identified using voxel-based morphometry. Eur Arch Psychiatry Clin Neurosci 2011;261:313-22.
12. Rimol LM, Hartberg CB, Nesvag R, et al. Cortical Thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry 2010;68:41-50.
13. Quidé Y, Morris RW, Shepherd AM, et al. Task-related fronto-striatal functional connectivity during working memory performance in schizophrenia. Schizophr Res 2013;150:468-75.
14. Gur RE, Calkins ME, Gur RC, et al. The consortium on the genetics of schizophrenia: neurocognitive endophenotypes. Schizophr Bull 2007;33:49-68.
15. Glahn DC, Almasy L, Barguil M, et al. Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry 2010;67:168-77.
16. Krabbendam L, Arts B, van Os J, et al. Cognitive functioning in patients with schizophrenia and bipolar disorder: a quantitative review. Schizophr Res 2005;80:137-49.
17. Glahn DC, Bearden CE, Cakir S, et al. Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis. Bipolar Disord 2006;8:117-23.
18. Glahn DC, Almasy L, Blangero J, et al. Adjudicating neurocognitive endophenotypes for schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2007;144B:242-9.
19. Goldberg TE, Egan MF, Gscheidle T, et al. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase val158met genotype and schizophrenia. Arch Gen Psychiatry 2003;60:889-96.
20. Egan MF, Goldberg TE, Kolachana BS, et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 2001;98:6917-22.
21. Badcock JC, Michie PT, Rock D. Spatial working memory and planning ability: contrasts between schizophrenia and bipolar I disorder. Cortex 2005;41:753-63.
22. Vohringer PA, Barroilhet SA, Amerio A, et al. Cognitive impairment in bipolar disorder and schizophrenia: a systematic review. Front Psychiatry 2013;4:87.
23. Bora E, Yucel M, Pantelis C. Cognitive impairment in schizophrenia and affective psychoses: implications for DSM-V criteria and beyond. Schizophr Bull 2010;36:36-42.
24. Simonsen C, Sundet K, Vaskinn A, et al. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull 2011;37:73-83.
25. Cuthbert BN, Insel TR. Toward new approaches to psychotic disorders: the NIMH Research Domain Criteria project. Schizophr Bull 2010;36:1061-2.
26. Shepherd AM, Laurens KR, Matheson SL, et al. Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia. Neurosci Biobehav Rev 2012;36:1342-56.
27. Strakowski SM, DelBello MP, Adler C. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry 2005;10:105-16.
28. Callicott JH, Ramsey NF, Tallent K, et al. Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology 1998;18:186-96.
29. Arnone D, Cavanagh J, Gerber D, et al. Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. Br J Psychiatry 2009;195:194-201.
30. Ellison-Wright I, Bullmore E. Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophr Res 2010;117:1-12.
31. Strakowski SM, Delbello M, Adler C. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry 2005;10:105-16.
32. Bora E, et al. Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis. Schizophr Res 2011;127:46-57.
33. Killgore W, Rosso IM, Gruber SA, et al. Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder. Cogn Behav Neurol 2009;22:28-37.
34. Garlinghouse MA, Roth RM, Isquith PK, et al. Subjective rating of working memory is associated with frontal lobe volume in schizophrenia. Schizophr Res 2010;120:71-5.
35. Harms MP, Wang L, Csernansky JG, et al. Structure-function relationship of working memory activity with hippocampal and prefrontal cortex volumes. Brain Struct Funct 2013;218:173-86.
36. Hartberg CB, Sundet K, Rimol LM, et al. Brain cortical thickness and surface area correlates of neurocognitive performance in patients with schizophrenia, bipolar disorder, and healthy adults. J Int Neuropsychol Soc 2011;17:1080-93.
37. Hartberg CB, Sundet K, Rimol LM, et al. Subcortical brain volumes relate to neurocognition in schizophrenia and bipolar disorder and healthy controls. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1122-30.
38. Karlsgodt KH, van Erp TG, Poldrack RA, et al. Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia. Biol Psychiatry 2008;63:512-8.
39. Antonova E, Sharma T, Morris R, et al. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophr Res 2004;70:117-45.
40. Crespo-Facorro B, Barbadillo L, Pelayo-Terán JM, et al. Neuropsychological functioning and brain structure in schizophrenia. Int Rev Psychiatry 2007;19:325-36.
41. Cocchi L, Walterfang M, Testa R, et al. Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia. Schizophr Res 2009;115:163-72.
42. McGuffin P, Farmer A. A polydiagnostic application of operational criteria in studies of psychotic illness: development and validation of the OPCRIT system. Arch Gen Psychiatry 1991;48:764-70.
43. Castle DJ, Jablensky A, McGrath JJ, et al. The diagnostic interview for psychoses (DIP): development, reliability and applications. Psychol Med 2006;36:69-80.
44. Loughland C, Draganic D, McCabe K, et al. Australian Schizophrenia Research Bank: a database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia. Aust N Z J Psychiatry 2010;44:1029-35.
45. Mitchell PB, Johnston AK, Corry J, et al. Characteristics of bipolar disorder in an Australian specialist outpatient clinic: comparison across large datasets. Aust N Z J Psychiatry 2009;43:109-17.
46. Kay SR, Flszbein A, Opfer LA. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophr Bull 1987;13:261-76.
47. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington (DC): The Association; 1994.
48. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97-113.
49. Lovibond SH, Lovibond PF. Manual for the Depression Anxiety Stress Scales. 2nd edition. Sydney (AU): Psychology Foundation of Australia; 1995.
50. Wechsler D. Wechsler Abbreviated Scale of Intelligence (WASI). New York (NY): The Psychological Corporation; 1999.
51. Wechsler D. Wechsler Test of Adult Reading (WTAR). New York (NY): The Psychological Corporation; 2001.
52. Randolph C. Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). San Antonio (TX): The Psychological Corporation; 1998.
53. Wechsler D. Wechsler Adult Intelligence Scales. 3rd edition. New York (NY): The Psychological Corporation; 1997.
54. Spreen O, Strauss E. A compendium of neuropsychological tests: administration, norms, and commentary. New York (NY): Oxford University Press; 1998.
55. Ivleva EI, Bidesi AS, Keshavan MS, et al. Gray matter volume as an intermediate phenotype for psychosis: bipolar-schizophrenia network on intermediate phenotypes (B-SNIP). Am J Psychiatry 2013;170:1285-96.
56. Bilder RM, Volavka J, Czobor P, et al. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 2002;52:701-7.
57. Burdick KE, Funke B, Goldberg JF, et al. COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord 2007;9:370-6.
58. Carless MA, Glahn DC, Johnson MP, et al. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Mol Psychiatry 2011;16:1096-104.
59. Lawrie SM, Hall J, McIntosh AM, et al. Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential. Br J Pharmacol 2008;153(Supple 1):S120-4.
60. Ohnishi T, Hashimoto R, Mori T, et al. The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia. Brain 2006;129:399-410.
61. Ehrlich S, Morrow EM, Roffman JL, et al. The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. Neuroimage 2010;53:992-1000.
62. Callicott JH, Straub RE, Pezawas L, et al. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A 2005;102:8627-32.
63. Owen MJ, Craddock N, Jablensky A. The genetic deconstruction of psychosis. Schizophr Bull 2007;33:905-11.
64. Wager TD, Smith E. Neuroimaging studies of working memory: a meta-analysis. Cogn Affect Behav Neurosci 2003;3:255-74.
65. Antonova E, Kumari V, Morris R, et al. The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biol Psychiatry 2005;58:457-67.
66. Brass M, Derrfuss J, Forstmann B, et al. The role of the inferior frontal junction area in cognitive control. Trends Cogn Sci 2005;9:314-6.
67. Derrfuss J, Brass M, Neumann J, et al. Involvement of the inferior frontal junction in cognitive control: meta-analyses of switching and Stroop studies. Hum Brain Mapp 2005;25:22-34.
68. Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends Cogn Sci 2004;8:170-7.
69. Ehrlich S, Brauns S, Yendiki A, et al. Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls. Schizophr Bull 2012;38:1050-62.
70. Tan H-Y, Choo WC, Fones CS, et al. fMRI study of maintenance and manipulation processes within working memory in first-episode schizophrenia. Am J Psychiatry 2005;162:1849-58.
71. Townsend J, Bookheimer SY, Foland-Ross LC, et al. fMRI abnormalities in dorsolateral prefrontal cortex during a working memory task in manic, euthymic and depressed bipolar subjects. Psychiatry Res 2010;182:22-9.
72. Suga M, Yamasue H, Abe O, et al. Reduced gray matter volume of Brodmann’s area 45 is associated with severe psychotic symptoms in patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci 2010;260:465-73.
73. Iwashiro N, Suga M, Takano Y, et al. Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia. Schizophr Res 2012;137:124-31.
74. Gaser C, Nenadic I, Volz HP, et al. Neuroanatomy of “hearing voices”: a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia. Cereb Cortex 2004;14:91-6.
75. Bergé D, Carmona S, Rovira M, et al. Gray matter volume deficits and correlation with insight and negative symptoms in first-psychotic-episode subjects. Acta Psychiatr Scand 2011;123:431-9.
76. Fusar-Poli P, Borgwardt S, Crescini A, et al. Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis. Neurosci Biobehav Rev 2011;35:1175-85.
77. Nenadic I, Sauer H, Smesny S, et al. Aging effects on regional brain structural changes in schizophrenia. Schizophr Bull 2012;38:838-44.
78. Kirkpatrick B, Messias E, Harvey PD, et al. Is schizophrenia a syndrome of accelerated aging? Schizophr Bull 2008;34:1024-32.
79. Koutsouleris N, Davatzikos C, Borgwardt S, et al. Accelerated brain aging in schizophrenia and beyond: a neuroanatomical marker of psychiatric disorders. Schizophr Bull 2013 Oct. 13 [Epub ahead of print].
80. Mechelli A, Price CJ, Friston KJ, et al. Voxel-based morphometry of the human brain: methods and applications. Current Medical Imaging Reviews 2005;1:105-13.
81. Hallahan B, Newell J, Soares JC, et al. Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data. Biol Psychiatry 2011;69:326-35.
82. Leung M, Cheung C, Yu K, et al. Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting. Schizophr Bull 2011;37:199-211.