Testing the limits of rational design by engineering pH sensitivity into membrane-active peptides

Biochimica et Biophysica Acta - Biomembranes

Volumn 1848, Issue 4, 2015, Pages 951-957

  Wiedman, Gregory ^a   Wimley, William C ^b   Hristova, Kalina ^a  

^a Johns Hopkins University   (United States)

^b TULANE UNIVERSITY   (United States)

Author keywords

Membrane; Peptides; pH sensitivity

Indexed keywords

GALA PEPTIDE; MELP5 PEPTIDE; MEMBRANE PROTEIN; PHLIP PEPTIDE; UNCLASSIFIED DRUG; LIPID BILAYER; LIPOSOME; MELITTIN; PEPTIDE; PHLIP PROTEIN; PHOSPHATIDYLCHOLINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING KINETICS; CHANNEL GATING; LIPID BILAYER; MACROMOLECULE; MEMBRANE BINDING; PH; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; SENSITIVITY ANALYSIS; CELL MEMBRANE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG DESIGN; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; CELL MEMBRANE; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HYDROGEN-ION CONCENTRATION; LIPID BILAYERS; LIPOSOMES; MELITTEN; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHATIDYLCHOLINES;

EID: 84920964209     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2014.12.023     Document Type: Article

References (29)

1. Y. Shai Mode of action of membrane active antimicrobial peptides Biopolymers 66 2002 236 248
2. R.E.W. Hancock, and R. Lehrer Cationic peptides: a new source of antibiotics Trends Biotechnol. 16 1998 82 88
3. K.L. Brown, and R.E.W. Hancock Cationic host defense (antimicrobial) peptides Curr. Opin. Immunol. 18 2006 24 30
4. D.M. Easton, A. Nijnik, M.L. Mayer, and R.E.W. Hancock Potential of immunomodulatory host defense peptides as novel anti-infectives Trends Biotechnol. 27 2009 582 590
5. R.E.W. Hancock, and H.G. Sahl Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Nat. Biotechnol. 24 2006 1551 1557
6. H. Jenssen, P. Hamill, and R.E.W. Hancock Peptide antimicrobial agents Clin. Microbiol. Rev. 19 2006 491 511
7. J.F. Marcos, and M. Gandia Antimicrobial peptides: to membranes and beyond Expert Opin. Drug Discov. 4 2009 659 671
8. P. Nicolas Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides FEBS J. 276 2009 6483 6496
9. W.C. Wimley Describing the mechanism of antimicrobial peptide action with the interfacial activity model ACS Chem. Biol. 5 2010 905 917
10. W.C. Wimley, and K. Hristova Antimicrobial peptides: successes, challenges and unanswered questions J. Membr. Biol. 239 2011 27 34
11. A.J. Krauson, J. He, and W.C. Wimley Gain-of-function analogues of the pore-forming peptide melittin selected by orthogonal high-throughput screening J. Am. Chem. Soc. 134 2012 12732 12741
12. G. Wiedman, T. Fuselier, J. He, P.C. Searson, K. Hristova, and W.C. Wimley Highly efficient macromolecule-sized poration of lipid bilayers by a synthetically evolved peptide J. Am. Chem. Soc. 136 2014 4724 4731
13. G. Wiedman, K. Herman, P. Searson, W.C. Wimley, and K. Hristova The electrical response of bilayers to the bee venom toxin melittin: evidence for transient bilayer permeabilization Biochim. Biophys. Acta 1828 2013 1357 1364
14. Y. Shai, and Z. Oren From "carpet" mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides Peptides 22 2001 1629 1641
15. L. Yao, J. Daniels, D. Wijesinghe, O.A. Andreev, and Y.K. Reshetnyak pHLIP (R)-mediated delivery of PEGylated liposomes to cancer cells J. Control. Release 167 2013 228 237
16. O.A. Andreev, D.M. Engelman, and Y.K. Reshetnyak pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents Mol. Membr. Biol. 27 2010 341 352
17. J. Fendos, F.N. Barrera, and D.M. Engelman Aspartate embedding depth affects pHLIP's insertion pK(a) Biochemistry 52 2013 4595 4604
18. R.A. Parente, S. Nir, and F.C. Szoka Jr. Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA Biochemistry 29 1990 8720 8728
19. N.K. Subbarao, R.A. Parente, F.C. Szoka, L. Nadasdi, and K. Pongracz pH-dependent bilayer destabilization by an amphipathic peptide Biochemistry 26 1987 2964 2972
20. L.D. Mayer, M.J. Hope, and P.R. Cullis Vesicles of variable sizes produced by a rapid extrusion procedure Biochim. Biophys. Acta 858 1986 161 168
21. M.J. Hope, M.B. Bally, L.D. Mayer, A.S. Janoff, and P.R. Cullis Generation of multilamellar and unilamellar phospholipid vesicles Chem. Phys. Lipids 40 1986 89 107
22. J.C. Stewart Colorimetric determination of phospholipids with ammonium ferrothiocyanate Anal. Biochem. 104 1980 10 14
23. A.S. Ladokhin, S. Jayasinghe, and S.H. White How to measure and analyze tryptophan fluorescence in membranes properly, and why bother? Anal. Biochem. 285 2000 235 245
24. S.H. White, and W.C. Wimley Membrane protein folding and stability: physical principles Annu. Rev. Biophys. Biomol. Struct. 28 1999 319 365
25. W.C. Wimley, and S.H. White Experimentally determined hydrophobicity scale for proteins at membrane interfaces Nat. Struct. Biol. 3 1996 842 848
26. S.H. White, W.C. Wimley, A.S. Ladokhin, and K. Hristova Protein folding in membranes: determining the energetics of peptide-bilayer interactions Methods Enzymol. 295 1998 62 87
27. P.F. Almeida, and A. Pokorny Mechanisms of antimicrobial, cytolytic, and cell-penetrating peptides: from kinetics to thermodynamics Biochemistry 48 2009 8083 8093
28. R. Rathinakumar, W.F. Walkenhorst, and W.C. Wimley Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity J. Am. Chem. Soc. 131 2009 7609 7617
29. J.R. Marks, J. Placone, K. Hristova, and W.C. Wimley Spontaneous membrane-translocating peptides by orthogonal high-throughput screening J. Am. Chem. Soc. 133 2011 8995 9004