Immunomodulatory effects of chitin microparticles on Leishmania major-infected BALB/c mice

Parasitology International

Volumn 64, Issue 2, 2015, Pages 219-221

  Ghotloo, Somayeh ^a   Hoseini, Mostafa Haji Molla ^a   Alimohammadian, Mohammad Hossein ^b   Khaze, Vahid ^b   Memarnejadian, Arash ^b   Rostami, Ali ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Chitin microparticles; Cytokine; Immunomodulation; Leishmania major

Indexed keywords

CHITIN; CHITIN MICROPARTICLE; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DRUG DOSAGE FORM; IMMUNOLOGICAL ADJUVANT;

ANIMAL EXPERIMENT; ARTICLE; BALB/C NUDE MOUSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOMODULATION; IN VIVO STUDY; LEISHMANIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE; ANIMAL; BAGG ALBINO MOUSE; DRUG DOSAGE FORM; DRUG EFFECTS; FEMALE; IMMUNOLOGY; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; TH1 CELL;

LEISHMANIA MAJOR; MUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CHITIN; DOSAGE FORMS; FEMALE; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; TH1 CELLS;

EID: 84920938374     PISSN: 13835769     EISSN: 18730329     Source Type: Journal    
DOI: 10.1016/j.parint.2014.12.007     Document Type: Article

References (19)

1. Lee C.G., Da Silva C.A., Dela Cruz C.S. Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol 2011, 73:479-501.
2. Da Silva C.A., Chalouni C., Williams A., Hartl D., Lee C.G., Elias J.A. Chitin is a size-dependent regulator of macrophage TNF and IL-10 production. J Immunol 2009, 182:3573-3582.
3. Shibata Y., Foster L.A., Bradfield J.F., Myrvik Q.N. Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse. J Immunol 2000, 164:1314-1321.
4. Shibata Y., Honda I., Justice J.P., Van Scott M.R., Nakamura R.M., Myrvik Q.N. Th1 adjuvant N-acetyl-d-glucosamine polymer up-regulates Th1 immunity but down-regulates Th2 immunity against a mycobacterial protein (MPB-59) in interleukin-10-knockout and wild-type mice. Infect Immun 2001, 69:6123-6130.
5. Baaten B.J., Clarke B., Strong P., Hou S. Nasal mucosal administration of chitin microparticles boosts innate immunity against influenza A virus in the local pulmonary tissue. Vaccine 2010, 28:4130-4137.
6. Okwor I., Mou Z., Liu D., Uzonna J. Protective immunity and vaccination against cutaneous leishmaniasis. Front Immunol 2012, 3:128.
7. Rojas R., Valderrama L., Valderrama M., Varona M.X., Ouellette M., Saravia N.G. Resistance to antimony and treatment failure in human Leishmania (Viannia) infection. J Infect Dis 2006, 193:1375-1383.
8. Marincola F. Interleukin-10. Texas: Landes. Bioscience 2006, 111-112.
9. Dehghani F., Haji Molla Hoseini M., Memarnejadian A., Yeganeh F., Rezaie A.M., Khaze V., et al. Immunomodulatory activities of chitin microparticles on Leishmania major-infected murine macrophages. Arch Med Res 2011, 42:572-576.
10. Da Silva C.A., Hartl D., Liu W., Lee C.G., Elias J.A. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol 2008, 181:4279-4286.
11. Lima H.C., Bleyenberg J.A., Titus R.G. A simple method for quantifying Leishmania in tissues of infected animals. Parasitol Today 1997, 13:80-82.
12. Daneshvar H., Hagan P., Phillips R.S. Leishmania mexicana H-line attenuated under pressure of gentamicin, potentiates a Th1 response and control of cutaneous leishmaniasis in BALB/c mice. Parasite Immunol 2003, 25:589-596.
13. Liew F.Y., Li Y., Millott S. Tumour necrosis factor (TNF-alpha) in leishmaniasis. II. TNF-alpha-induced macrophage leishmanicidal activity is mediated by nitric oxide from l-arginine. Immunology 1990, 71:556-559.
14. Heinzel F.P., Sadick M.D., Holaday B.J., Coffman R.L., Locksley R.M. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med 1989, 169:59-72.
15. Reese T.A., Liang H.E., Tager A.M., et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 2007, 447:92-96.
16. Lee C.G., Da Silva C.A., Lee J.Y., Hartl D., Elias J.A. Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol 2008, 20:684-689.
17. Kogiso M., Nishiyama A., Shinohara T. Chitin particles induce size-dependent but carbohydrate-independent innate eosinophilia. J Leukoc Biol 2011, 90:167-176.
18. Gonzalez-Lombana C., Gimblet C., Bacellar O. IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection. PLoS Pathog 2013, 9:e1003243.
19. Nagatani K., Wang S., Llado V. Chitin microparticles for the control of intestinal inflammation. Inflamm Bowel Dis 2012, 18:1698-1710.