Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity

Cellular Physiology and Biochemistry

Volumn 34, Issue 6, 2014, Pages 2200-2208

  Ivanova, Vilena V ^a   Khaiboullina, Svetlana F ^a,b   Cherenkova, Ekaterina E ^a   Martynova, Ekaterina V ^a   Nevzorova, Tatiana A ^a   Kunst, Michail A ^c   Sibgatullin, Timur B ^c   Maksudova, Adelia N ^c   Oliveira, Paulo J ^d   Lombardi, Vincent C ^a,b   Palotás, András ^a,e,f   Rizvanov, Albert A ^a,f  

^a KAZAN FEDERAL UNIVERSITY   (Russian Federation)

^b UNIVERSITY OF NEVADA   (United States)

^c KAZAN STATE MEDICAL UNIVERSITY   (Russian Federation)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e Asklepios Med (private medical practice and research center)   (Hungary)

^f UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Auto antibody; Auto antigens; Auto immune disease; Biomarker; Mitochondria; Nucleic acid; Systemic lupus erythematosus (SLE)

Indexed keywords

GENOMIC DNA; GENOMIC RNA; MITOCHONDRIAL DNA; DNA; RNA;

ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL ELECTROPHORESIS; HUMAN; IMMUNOREACTIVITY; PATHOGENESIS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RUSSIAN FEDERATION; SYSTEMIC LUPUS ERYTHEMATOSUS; ADOLESCENT; ADULT; FEMALE; HEK293 CELL LINE; HUMAN GENOME; IMMUNOLOGY; MALE; MITOCHONDRION; PATHOLOGY;

ADOLESCENT; ADULT; DNA; DNA, MITOCHONDRIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOME, HUMAN; HEK293 CELLS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MITOCHONDRIA; RNA;

EID: 84920915026     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000369663     Document Type: Article

References (46)

1. Soto ME, Vallejo M, Guillen F, Simon JA, Arena E, Reyes PA: Gender impact in systemic lupus erythematosus. Clin Exp Rheumatol 2004;22:713-721
2. Haugbro K, Nossent JC, Winkler T, Figenschau Y, Rekvig OP: Anti-dsdna antibodies and disease classification in antinuclear antibody positive patients: the role of analytical diversity. Ann Rheum Dis 2004;63:386-394
3. Lopez-Hoyos M, Cabeza R, Martinez-Taboada VM, Crespo J, SanSegundo D, Blanco R, Lopez-Escribano H, Pena M, Rodriguez-Valverde V: Clinical disease activity and titers of anti-dsdna antibodies measured by an automated immunofluorescence assay in patients with systemic lupus erythematosus. Lupus 2005;14:505-509
4. Winfield JB, Faiferman I, Koffler D: Avidity of anti-DNA antibodies in serum and igg glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis. J Clin Invest 1977;59:90-96
5. Hochberg MC: Updating the american college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725
6. Gualtierotti R, Biggioggero M, Penatti AE, Meroni PL: Updating on the pathogenesis of systemic lupus erythematosus. Autoimmun Rev 2010;10:3-7
7. Ippolito A, Wallace DJ, Gladman D, Fortin PR, Urowitz M, Werth V, Costner M, Gordon C, Alarcon GS, Ramsey-Goldman R, Maddison P, Clarke A, Bernatsky S, Manzi S, Bae SC, Merrill JT, Ginzler E, Hanly JG, Nived O, Sturfelt G, Sanchez-Guerrero J, Bruce I, Aranow C, Isenberg D, Zoma A, Magder LS, Buyon J, Kalunian K, Dooley MA, Steinsson K, van Vollenhoven RF, Stoll T, Weisman M, Petri M: Autoantibodies in systemic lupus erythematosus: Comparison of historical and current assessment of seropositivity. Lupus 2011;20:250-255
8. Schur PH, Monroe M: Antibodies to ribonucleic acid in systemic lupus erythematosus. Proc Natl Acad Sci USA 1969;63:1108-1112
9. Al-Shobaili HA, Rasheed Z: Physicochemical and immunological studies on mitochondrial DNA modified by peroxynitrite: Implications of neo-epitopes of mitochondrial DNA in the etiopathogenesis of systemic lupus erythematosus. Lupus 2013;22:1024-1037
10. Vyshkina T, Sylvester A, Sadiq S, Bonilla E, Canter JA, Perl A, Kalman B: Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus. Clin Immunol 2008;129:31-35
11. Shiraishi W, Hayashi S, Kamada T, Isobe N, Yamasaki R, Murai H, Ohyagi Y, Kira J: A case of neuromyelitis optica harboring both anti-Aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy. Mult Scler 2014;20:258-260
12. Zhang B, Angelidou A, Alysandratos KD, Vasiadi M, Francis K, Asadi S, Theoharides A, Sideri K, Lykouras L, Kalogeromitros D, Theoharides TC: Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children. J Neuroinflamm 2010;7:80
13. Quaio CR, Carvalho JF, da Silva CA, Bueno C, Brasil AS, Pereira AC, Jorge AA, Malaquias AC, Kim CA, Bertola DR: Autoimmune disease and multiple autoantibodies in 42 patients with rasopathies. Am J Med Genet A 2012;158A:1077-1082
14. Knight JS, Carmona-Rivera C, Kaplan MJ: Proteins derived from neutrophil extracellular traps may serve as self-Antigens and mediate organ Damage in autoimmune diseases. Front Immunol 2012;3:380
15. Munoz LE, van Bavel C, Franz S, Berden J, Herrmann M, van Der Vlag J: Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus 2008;17:371-375
16. Bijl M, Reefman E, Horst G, Limburg PC, Kallenberg CG: Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: Correlates with decreased serum levels of complement. Ann Rheum Dis 2006;65:57-63
17. Ren Y, Tang J, Mok MY, Chan AW, Wu A, Lau CS: Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis Rheum 2003;48:2888-2897
18. Shoshan Y, Shapira I, Toubi E, Frolkis I, Yaron M, Mevorach D: Accelerated fas-mediated apoptosis of monocytes and maturing macrophages from patients with systemic lupus erythematosus: Relevance to in vitro impairment of interaction with ic3b-opsonized apoptotic cells. J Immunol 2001;167:5963-5969
19. Garcia-Romo GS, Caielli S, Vega B, Connolly J, Allantaz F, Xu Z, Punaro M, Baisch J, Guiducci C, Coffman RL, Barrat FJ, Banchereau J, Pascual V: Netting neutrophils are major inducers of type i ifn production in pediatric systemic lupus erythematosus. Sci Transl Med 2011;3:73ra20
20. Savill J: Recognition and phagocytosis of cells undergoing apoptosis. Brit Med Bull 1997;53:491-508
21. Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, Earp HS, Matsushima G, Reap EA: Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 2002;196:135-140
22. Dieker JW, van Der Vlag J, Berden JH: Triggers for anti-chromatin autoantibody production in SLE. Lupus 2002;11:856-864
23. Cairns AP, Crockard AD, McConnell JR, Courtney PA, Bell AL: Reduced expression of cd44 on monocytes and neutrophils in systemic lupus erythematosus: Relations with apoptotic neutrophils and disease activity. Ann Rheum Dis 2001;60:950-955
24. Skiljevic D, Jeremic I, Nikolic M, Andrejevic S, Sefik-Bukilica M, Stojimirovic B, Bonaci-Nikolic B: Serum dnase i activity in systemic lupus erythematosus: Correlation with immunoserological markers, the disease activity and organ involvement. Clin Chem Lab Med 2013;51:1083-1091
25. Casciola-Rosen L, Rosen A, Petri M, Schlissel M: Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci USA 1996;93:1624-1629
26. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994;179:1317-1330
27. Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E: Protection against HIV-1 gp120-induced brain Damage by neuronal expression of human amyloid precursor protein. J Exp Med 1995;181:1551-1556
28. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG: Sequence and organization of the human mitochondrial genome. Nature 1981;290:457-465
29. Alarcon-Segovia D, Fishbein E: Immunochemical characterization of the anti-rna antibodies found in scleroderma and systemic lupus erythematosus. I. Differences in reactivity with poly (u) and poly-(a) poly (u). J Immunol 1975;115:28-31
30. Wilusz J, Keene JD: Autoantibodies specific for u1 rna and initiator methionine trna. J Biol Chem 1986;261:5467-5472
31. Ara J, Ali A, Ali R: Antibodies against free radical modified native DNA recognize b-conformation. Immunol Invest 1992;21:553-563
32. Blount S, Griffiths H, Emery P, Lunec J: Reactive oxygen species modify human DNA, eliciting a more discriminating antigen for the diagnosis of systemic lupus erythematosus. Clin Exp Immunol 1990;81:384-389
33. Sano H, Morimoto C: Dna isolated from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus is rich in guanine-cytosine content. J Immunol 1982;128:1341-1345
34. Sano H, Takai O, Harata N, Yoshinaga K, Kodama-Kamada I, Sasaki T: Binding properties of human anti-DNA antibodies to cloned human DNA fragments. Scand. J Immunol 1989;30:51-63
35. Van Helden PD: Potential z-DNA-forming elements in serum DNA from human systemic lupus erythematosus. J Immunol 1985;134:177-179
36. Wedderburn LR, McHugh NJ, Chinoy H, Cooper RG, Salway F, Ollier WE, McCann LJ, Varsani H, Dunphy J, North J, Davidson JE, Juvenile Dermatomyositis Research G: HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. Rheumatology 2007;46:1786-1791
37. Krapf F, Herrmann M, Leitmann W, Kalden JR: Antibody binding of macromolecular DNA and rna in the plasma of sle patients. Clin Exp Immunol 1989;75:336-342
38. Hong EE, Okitsu CY, Smith AD, Hsieh CL: Regionally specific and genome-wide analyses conclusively demonstrate the absence of cpg methylation in human mitochondrial DNA. Mol Cell Biol 2013;33:2683-2690
39. Collins LV, Hajizadeh S, Holme E, Jonsson IM, Tarkowski A: Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukocyte Biol 2004;75:995-1000
40. Ytterberg SR, Schnitzer TJ: Serum interferon levels in patients with systemic lupus erythematosus. Arthritis Rheum 1982;25:401-406
41. Kim T, Kanayama Y, Negoro N, Okamura M, Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus. Clin Exp Immunol 1987;70:562-569
42. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S, Liu YJ: The nature of the principal type 1 interferon-producing cells in human blood. Science 1999;284:1835-1837
43. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C: Innate antiviral responses by means of tlr7-mediated recognition of single-stranded RNA. Science 2004;303:1529-1531
44. Kerkmann M, Rothenfusser S, Hornung V, Towarowski A, Wagner M, Sarris A, Giese T, Endres S, Hartmann G: Activation with cpg-A and cpg-b oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J Immunol 2003;170:4465-4474
45. Puig M, Tosh KW, Schramm LM, Grajkowska LT, Kirschman KD, Tami C, Beren J, Rabin RL, Verthelyi D: Tlr9 and tlr7 agonists mediate distinct type i ifn responses in humans and nonhuman primates in vitro and in vivo. J Leukocyte Biol 2012;91:147-158
46. Ries M, Schuster P, Thomann S, Donhauser N, Vollmer J, Schmidt B: Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation. J Leukocyte Biol 2013;94:123-135