UlaR activates expression of the ula operon in Streptococcus pneumoniae in the presence of ascorbic acid

Microbiology (United Kingdom)

Volumn 161, Issue 1, 2015, Pages 41-49

  Afzal, Muhammad ^a   Shafeeq, Sulman ^b   Henriques Normark, Birgitta ^b   Kuipers, Oscar P ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; BETA GALACTOSIDASE; CARBOHYDRATE; GLUCOSE; PROTEIN BINDING; TRANSCRIPTION FACTOR;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GENE LOCATION; MEMBRANE COMPONENT; NONHUMAN; OPERON; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS DYSGALACTIAE; STREPTOCOCCUS EQUI; STREPTOCOCCUS MITIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STREPTOCOCCUS SANGUINIS; STREPTOCOCCUS SUIS; STREPTOCOCCUS UBERIS; ULA OPERON; ULAR MUTANT; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENE ORDER; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; POSITION WEIGHT MATRIX; TRANSCRIPTION INITIATION;

STREPTOCOCCUS PNEUMONIAE; ULA;

ASCORBIC ACID; BASE SEQUENCE; CONSERVED SEQUENCE; GENE EXPRESSION REGULATION, BACTERIAL; GENE ORDER; GLUCOSE; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OPERON; POSITION-SPECIFIC SCORING MATRICES; PROTEIN BINDING; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84920903663     PISSN: 13500872     EISSN: 14652080     Source Type: Journal    
DOI: 10.1099/mic.0.083899-0     Document Type: Article

References (36)

1. Afzal, M., Shafeeq, S. & Kuipers, O. P. (2014). LacR is a repressor of lacABCD and LacT is an activator of lacTFEG, constituting the lac gene cluster in Streptococcus pneumoniae. Appl Environ Microbiol 80, 5349-5358.
2. Bailey, T. L. & Elkan, C. (1994). Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc. Int. Conf. Intell. Syst. Mol. Biol. ISMB Int. Conf. Intell. Syst. Mol. Biol. 2, 28-36.
3. Bidossi, A., Mulas, L., Decorosi, F., Colomba, L., Ricci, S., Pozzi, G., Deutscher, J., Viti, C. & Oggioni, M. R. (2012). A functional genomics approach to establish the complement of carbohydrate transporters in Streptococcus pneumoniae. PLoS ONE 7, e33320.
4. Campos, E., Aguilar, J., Baldoma, L. & Badia, J. (2002). The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli. J Bacteriol 184, 6065-6068.
5. Campos, E., Baldoma, L., Aguilar, J. & Badia, J. (2004). Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in L-Ascorbate dissimilation in Escherichia coli. J Bacteriol 186, 17201728.
6. Campos, E., Montella, C., Garces, F., Baldoma, L., Aguilar, J. & Badia, J. (2007). Aerobic L-ascorbate metabolism and associated oxidative stress in Escherichia coli. Microbiology 153, 3399-3408.
7. Campos, E., de la Riva, L., Garces, F., Gimenez, R., Aguilar, J., Baldoma, L. & Badia, J. (2008). The yiaKLX1X2PQRS and ulaABCDEFG gene systems are required for the aerobic utilization of L-ascorbate in Klebsiella pneumoniae strain 13882 with L-ascorbate- 6-phosphate as the inducer. J Bacteriol 190, 6615-6624.
8. Carvalho, S. M., Kloosterman, T. G., Kuipers, O. P. & Neves, A. R. (2011). CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae D39. PLos One 6, e26707.
9. Fujita, Y. (2009). Carbon catabolite control of the metabolic network in Bacillus subtilis. Biosci Biotechnol Biochem 73, 245-259.
10. Giammarinaro, P. & Paton, J. C. (2002). Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae. Infect Immun 70, 5454-5461.
11. Halfmann, A., Hakenbeck, R. & Bruckner, R. (2007). A new integrative reporter plasmid for Streptococcus pneumoniae. FEMS Microbiol Lett 268, 217-224.
12. Heravi, K. M., Wenzel, M. & Altenbuchner, J. (2011). Regulation of mtl operon promoter of Bacillus subtilis: requirements of its use in expression vectors. Microb Cell Fact 10, 83.
13. Ibanez, E., Campos, E., Baldoma, L., Aguilar, J. & Badia, J. (2000). Regulation of expression of the yiaKLMNOPQRS operon for carbohydrate utilization in Escherichia coli: involvement of the main transcriptional factors. J Bacteriol 182, 4617-4624.
14. Israelsen, H., Madsen, S. M., Vrang, A., Hansen, E. B. & Johansen, E. (1995). Cloning and partial characterization of regulated promoters from Lactococcus lactis Tn917-lacZ integrants with the new promoter probe vector, pAK80. Appl Environ Microbiol 61, 2540-2547.
15. Iyer, R. & Camilli, A. (2007). Sucrose metabolism contributes to in vivo fitness of Streptococcus pneumoniae. Mol Microbiol 66, 1-13.
16. Iyer, R., Baliga, N. S. & Camilli, A. (2005). Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae. J Bacteriol 187, 8340-8349.
17. Joyet, P., Derkaoui, M., Poncet, S. & Deutscher, J. (2010). Control of Bacillus subtilis mtl operon expression by complex phosphorylation- dependent regulation of the transcriptional activator MtlR. Mol Microbiol 76, 1279-1294.
18. Joyet, P., Bouraoui, H., Ake, F. M. D., Derkaoui, M., Zebre, A. C., Cao, T. N., Ventroux, M., Nessler, S., Noirot-Gros, M.-F. & other authors (2013). Transcription regulators controlled by interaction with enzyme IIB components of the phosphoenolpyruvate: sugar phosphotransferase system. Biochim Biophys Acta 1834, 1415-1424.
19. Kloosterman, T. G., Bijlsma, J. J. E., Kok, J. & Kuipers, O. P. (2006). To have neighbour’s fare: extending the molecular toolbox for Streptococcus pneumoniae. Microbiology 152, 351-359.
20. Lanie, J. A., Ng, W. L., Kazmierczak, K. M., Andrzejewski, T. M., Davidsen, T. M., Wayne, K. J., Tettelin, H., Glass, J. I. & Winkler, M. E. (2007). Genome sequence of Avery’s virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6. J Bacteriol 189, 38-51.
21. Leenhouts, K., Venema, G. & Kok, J. (1998). A lactococcal pWV01 based integration toolbox for bacteria. Methods Cell Sci 20, 35-50.
22. Mehmeti, I., Solheim, M., Nes, I. F. & Holo, H. (2013). Enterococcus faecalis grows on ascorbic acid. Appl Environ Microbiol 79, 47564758.
23. Nieto, C., Espinosa, M. & Puyet, A. (1997). The maltose/maltodextrin regulon of Streptococcus pneumoniae. Differential promoter regulation by the transcriptional repressor MalR. J Biol Chem 272, 30860-30865.
24. Novichkov, P. S., Laikova, O. N., Novichkova, E. S., Gelfand, M. S., Arkin, A. P., Dubchak, I. & Rodionov, D. A. (2010). RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes. Nucleic Acids Res 38 (Database issue), D111-D118.
25. Rosenow, C., Maniar, M. & Trias, J. (1999). Regulation of the a- galactosidase activity in Streptococcus pneumoniae: characterization of the raffinose utilization system. Genome Res 9, 1189-1197.
26. Shafeeq, S., Yesilkaya, H., Kloosterman, T. G., Narayanan, G., Wandel, M., Andrew, P. W., Kuipers, O. P. & Morrissey, J. A. (2011a). The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae. Mol Microbiol 81, 1255-1270.
27. Shafeeq, S., Kloosterman, T. G. & Kuipers, O. P. (2011b). Transcriptional response of Streptococcus pneumoniae to Zn2+ limitation and the repressor/activator function of AdcR. Metallomics 3, 609-618.
28. Shafeeq, S., Kloosterman, T. G. & Kuipers, O. P. (2011c). CelR- mediated activation of the cellobiose-utilization gene cluster in Streptococcus pneumoniae. Microbiology 157, 2854-2861.
29. Shafeeq, S., Kuipers, O. P. & Kloosterman, T. G. (2013). Cellobiose- mediated gene expression in Streptococcus pneumoniae: a repressor function of the novel GntR-type regulator BguR. PLoS ONE 8, e57586.
30. Stulke, J. & Hillen, W. (1998). Coupling physiology and gene regulation in bacteria: the phosphotransferase sugar uptake system delivers the signals. Naturwissenschaften 85, 583-592.
31. Terzaghi, B. E. & Sandine, W. E. (1975). Improved medium for lactic streptococci and their bacteriophages. Appl Microbiol 29, 807-813.
32. Titgemeyer, F. & Hillen, W. (2002). Global control of sugar metabolism: a gram-positive solution. Antonie van Leeuwenhoek 82, 59-71.
33. Tobisch, S., Stulke, J. & Hecker, M. (1999). Regulation of the lic operon of Bacillus subtilis and characterization of potential phosphorylation sites of the LicR regulator protein by site-directed mutagenesis. J Bacteriol 181, 4995-5003.
34. Yew, W. S. & Gerlt, J. A. (2002). Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf- sga and yia-sgb operons. J Bacteriol 184, 302-306.
35. Zeng, L. & Burne, R. A. (2009). Transcriptional regulation of the cellobiose operon of Streptococcus mutans. J Bacteriol 191, 2153-2162.
36. Zhang, Z., Aboulwafa, M., Smith, M. H. & Saier, M. H., Jr (2003). The ascorbate transporter of Escherichia coli. J Bacteriol 185, 2243-2250.