Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury

Annals of Neurology

Volumn 77, Issue 1, 2015, Pages 177-182

  Valko, Philipp O ^a,b   Gavrilov, Yury V ^a,b,c   Yamamoto, Mihoko ^a   Finn, Kristen ^a   Reddy, Hasini ^a   Haybaeck, Johannes ^d   Weis, Serge ^e   Scammell, Thomas E ^a   Baumann, Christian R ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Russian Federation)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

^e KEPLER UNIVERSITY HOSPITAL   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; HISTAMINE; HISTIDINE DECARBOXYLASE; HYPOPHYSIS HORMONE; HYPOTHALAMUS HORMONE; MELANIN; MELANIN-CONCENTRATING HORMONE; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

ACTIMETRY; ACUTE HEART FAILURE; ACUTE KIDNEY FAILURE; ACUTE PANCREATITIS; AGED; ARTICLE; ASTROCYTE; AXONAL INJURY; BRAIN TISSUE; CELL COUNT; CLINICAL ARTICLE; COLON PERFORATION; DAYTIME SOMNOLENCE; FEMALE; GLIOSIS; HEAD INJURY; HISTAMINERGIC TUBEROMAMMILLARY NEURON; HOSPITAL ADMISSION; HUMAN; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTENSIVE CARE UNIT; LUNG EMBOLISM; MALE; MEDIAL FOREBRAIN BUNDLE; MENTAL DISEASE; MEYNERT BASAL NUCLEUS; NERVE FIBER DEGENERATION; PNEUMONIA; POLYSOMNOGRAPHY; POSTERIOR HYPOTHALAMUS; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIGNAL TRANSDUCTION; THALAMUS ANTERIOR NUCLEUS; TRAUMATIC BRAIN INJURY; TUBEROMAMMILLARY NUCLEUS; UPPER GASTROINTESTINAL BLEEDING; AUSTRIA; BRAIN INJURY; INJURY SCALE; LATERAL HYPOTHALAMUS; METABOLISM; NERVE CELL; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AUSTRIA; BRAIN INJURIES; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HISTAMINE; HISTIDINE DECARBOXYLASE; HUMANS; HYPOTHALAMIC AREA, LATERAL; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANINS; NEURONS; NEUROPEPTIDES; PITUITARY HORMONES; TRAUMA SEVERITY INDICES;

EID: 84920864213     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24298     Document Type: Article

References (20)

1. Maas AIR, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol 2008;7:728-741.
2. Frost RB, Farrer TJ, Primosch M, Hedges DW. Prevalence of traumatic brain injury in the general adult population: a meta-analysis. Neuroepidemiology 2012;40:154-159.
3. Stiefel MF, Spiotta A, Gracias VH, et al. Reduced mortality rate in patients with severe traumatic brain injury treated with brain tissue oxygen monitoring. J Neurosurg 2005;103:805-811.
4. Baumann CR, Werth E, Stocker R, et al. Sleep-wake disturbances 6 months after traumatic brain injury: a prospective study. Brain 2007;130:1873-1883.
5. Sommerauer M, Valko PO, Werth E, Baumann CR. Excessive sleep need following traumatic brain injury: a case-control study of 36 patients. J Sleep Res 2013;22:634-639.
6. Kaiser PR, Valko PO, Werth E, et al. Modafinil ameliorates excessive daytime sleepiness after traumatic brain injury. Neurology 2010;75:1780-1785.
7. Baumann CR, Bassetti CL, Valko PO, et al. Loss of hypocretin (orexin) neurons with traumatic brain injury. Ann Neurol 2009;66:555-559.
8. Valko PO, Gavrilov YV, Yamamoto M, et al. Increase of histaminergic tuberomammillary neurons in narcolepsy. Ann Neurol 2013;74:794-804.
9. Steininger TL, Alam MN, Gong H, et al. Sleep-waking discharge of neurons in the posterior lateral hypothalamus of the albino rat. Brain Res 1999;840:138-147.
10. Ko EM, Estabrooke IV, McCarthy M, Scammell TE. Wake-related activity of tuberomammillary neurons in rats. Brain Res 2003;992:220-226.
11. Takahashi K, Lin JS, Sakai K. Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse. J Neurosci 2006;26:10292-10298.
12. Roehrs TA, Tietz EI, Zorick FJ, Roth T. Daytime sleepiness and antihistamines. Sleep 1984;7:137-141.
13. Parmentier R, Ohtsu H, Djebbara-Hannas Z, et al. Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control. J Neurosci 2002;22:7695-7711.
14. John J, Thannickal TC, McGregor R, et al. Greatly increased numbers of histamine cells in human narcolepsy with cataplexy. Ann Neurol 2013;74:786-793.
15. Dauvilliers Y, Bassetti C, Lammers GJ, et al. Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial. Lancet Neurol 2013;12:1068-1075.
16. Tabbal SD, Tian L, Karimi M, et al. Low nigrostriatal reserve for motor parkinsonism in nonhuman primates. Exp Neurol 2012;237:355-362.
17. Luppi PH, Clément O, Fort P. Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control. Curr Opin Neurobiol 2013;14:714-718.
18. Monti JM, Torterolo P, Lagos P. Melanin-concentrating hormone control of sleep-wake behavior. Sleep Med Rev 2013;17:293-298.
19. Konadhode RR, Pelluru D, Blanco-Centurion C, et al. Optogenetic stimulation of MCH neurons increases sleep. J Neurosci 2013;33:10257-10263.
20. Jego S, Glasgow SD, Herrera CG, et al. Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. Nat Neurosci 2013;16:1637-1643.