Clinical trial of chlorhexidine vaginal irrigation to prevent peripartal infection in nulliparous women

American Journal of Obstetrics and Gynecology

Volumn 189, Issue 1, 2003, Pages 166-170

  Rouse, Dwight J ^a   Cliver, Suzanne ^a   Lincoln, Tina L ^a   Andrews, William W ^a   Hauth, John C ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Chlorhexidine; Clinical trial; Vaginal irrigation

Indexed keywords

CHLORHEXIDINE; CHLORHEXIDINE ACETATE; PLACEBO;

ADULT; ANTIMICROBIAL ACTIVITY; ARTICLE; CHORIOAMNIONITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENDOMETRITIS; FEMALE; FETUS OUTCOME; HUMAN; INFECTION RATE; INFECTION RISK; LAVAGE; MAJOR CLINICAL STUDY; NEWBORN INFECTION; NEWBORN MORBIDITY; NULLIPARA; PERINATAL INFECTION; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; VAGINA FLORA; VAGINA MUCOSA;

EID: 0038336564     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2003.322     Document Type: Article

References (13)

1. Vorherr H, Vorherr UF, Mehta P, Ulrich JA, Messer RH. Antimicrobial effect of chlorhexidine and povidone-iodine on vaginal bacteria. J Infect 1984;8:195-9.
2. Taha TE, Biggar RJ, Broadhead RL, Mtimavalye AR, Justesen AB, Liomba GN, et al. Effect of washing the birth canal with antiseptic solution on maternal and newborn morbidity and mortality, in Malawi: clinical trial. BMJ 1997;315:216-9.
3. Stray-Pedersen B, Bergan T, Hafstad A, Normann E, Gr_gaard J, Vangdal M. Vaginal disinfection with chlorhexidine during childbirth. Int J Antimicrob Agents 1999;12:245-51.
4. Case DE. Safety of hibitane, 1: laboratory experiments. J Clin Periodontol 1977;4:66-72.
5. Bergqvist-Karlsson A. Delayed and immediate-type hypersensitivity to chlorhexidine. Contact Dermatitis 1988;18:84-8.
6. Rouse DJ, Hauth JC, Andrews WW, Mills BB, Maher JE. Chlorhexidine vaginal irrigation for the prevention of peripartal infection: a placebo-controlled randomized clinical trial. Am J Obstet Gynecol 1997:176:617-22.
7. Burman LG, Christensen P, Christensen K, Fryklund B, Helgesson A-M, Svenningsen NW, et al. Prevention of excess neonatal morbidity associated with group B streptococci by vaginal chlorhexidine disinfection during labor. Lancet 1992;340:65-9.
8. Emilson CG. Susceptibility of various microorganisms to chlorhexidine. Scand J Dent Res 1977;85:255-65.
9. Gibbs RS, Duff P. Progress in pathogenesis and management of clinical intraamniotic infection. Am J Obstet Gynecol 1991;164:1317-26.
10. Sweeten KM, Eriksen NL, Blanco JD. Chlorhexidine versus sterile water vaginal wash during labor to prevent peripartum infection. Am J Obstet Gynecol 1997;176:426-30.
11. Dykes AK, Christensen KK, Christensen P, Kahlmeter G. Chlorhexidine for prevention of neonatal colonization with group B streptococci: II, chlorhexidine concentrations and recovery of group B streptococci following vaginal washing in pregnant women. Eur J Obstet Gynecol Reprod Biol 1983;16:167-72.
12. Lieberman E, O'Donoghue CO. Unintended effects of epidural analgesia during labor: a systematic review. Am J Obstet Gynecol 2002;186:S31-68.
13. Dashe JS, Rogers BB, McIntire DD, Leveno KJ. Epidural analgesia and intrapartum fever: placental findings. Obstet Gynecol 1999;93:341-4.