Generalizability of the disease state index prediction model for identifying patients progressing from mild cognitive impairment to Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 44, Issue 1, 2015, Pages 79-92

  Hall, Anette ^a   Muñoz Ruiz, Miguel ^a,b   Mattila, Jussi ^c   Koikkalainen, Juha ^c   Tsolaki, Magda ^d   Mecocci, Patrizia ^e   Kloszewska, Iwona ^f   Vellas, Bruno ^g   Lovestone, Simon ^h,i   Visser, Pieter Jelle ^j,k   Lötjonen, Jyrki ^c   Soininen, Hilkka ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^d ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^e UNIVERSITY OF PERUGIA   (Italy)

^f MEDICAL UNIVERSITY OF LODZ   (Poland)

^g UNIVERSITÉ DE TOULOUSE   (France)

^h Queen Mary University of London and Barts NIHR BRC NHS Trust National Institute for Health and Care Research   (United Kingdom)

ⁱ KING'S COLLEGE LONDON   (United Kingdom)

^j VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^k MAASTRICHT UNIVERSITY   (Netherlands)

more..

Author keywords

Alzheimer's disease; Computer assisted diagnosis; Dementia; Magnetic resonance imaging (MRI); Mild cognitive impairment

Indexed keywords

APOLIPOPROTEIN E;

AGED; ALZHEIMER DISEASE; ARTICLE; BOOTSTRAPPING; CEREBROSPINAL FLUID ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE STATE INDEX; FEMALE; GENOTYPE; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; MORPHOMETRICS; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSTIC ASSESSMENT; VALIDATION PROCESS; VOLUMETRY; VOXEL BASED MORPHOMETRY; AREA UNDER THE CURVE; BRAIN; DISEASE COURSE; GENETICS; IMAGE PROCESSING; MENTAL HEALTH; MIDDLE AGED; MULTICENTER STUDY (TOPIC); PATHOLOGY; PATHOPHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; AREA UNDER CURVE; BRAIN; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; MULTICENTER STUDIES AS TOPIC; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS;

EID: 84920859932     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-140942     Document Type: Article

References (60)

1. Mitchell AJ, Shiri-Feshki M (2009) Rate of progression of mild cognitive impairment to dementia - meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 119, 252-265.
2. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7 270-279.
3. Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P (2010) Revising the definition of Alzheimer's disease: A new lexicon. Lancet Neurol 9, 1118-1127.
4. Risacher SL, Saykin AJ, West JD, Shen L, Firpi HA, McDonald BC, Alzheimer's Disease Neuroimaging Initiative (ADNI) (2009) Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort. Curr Alzheimer Res 6, 347-361.
5. Lötjönen JM, Wolz R, Koikkalainen JR, Thurfjell L, Waldemar G, Soininen H, Rueckert D, Alzheimer's Disease Neuroimaging, Initiative (2010) Fast and robust multi-atlas segmentation of brain magnetic resonance images. Neuroimage 49, 2352-2365.
6. Wolz R, Julkunen V, Koikkalainen J, Niskanen E, Zhang DP, Rueckert D, Soininen H, Lötjönen J, Alzheimer's Disease Neuroimaging, Initiative (2011) Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease. PLoS One 6, e25446.
7. Koikkalainen J, Lötjönen J, Thurfjell L, Rueckert D, Waldemar G, Soininen H (2011) Multi-template tensor-based morphometry: Application to analysis of Alzheimer's disease. Neuroimage 56, 1134-1144.
8. Brun CC, Leporè N, Pennec X, Lee AD, Barysheva M, Madsen SK, Avedissian C, Chou YY, de Zubicaray GI, McMahon KL, Wright MJ, TogaAW, ThompsonPM(2009) Mapping the regional influence of genetics on brain structure variability- a tensor-based morphometry study. Neuroimage 48, 37-49.
9. Hua X, Leow AD, Parikshak N, Lee S, Chiang MC, Toga AW, Jack CR, Jr., Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging, Initiative (2008) Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects. Neuroimage 43, 458-469.
10. Chételat G, Landeau B, Eustache F, Mèzenge F, Viader F, de la Sayette V, Desgranges B, Baron JC (2005) Using voxelbased morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study. Neuroimage 27, 934-946.
11. Ashburner J, Friston KJ (2000) Voxel-based morphometry- the methods. Neuroimage 11, 805-821.
12. Mattila J, Koikkalainen J, Virkki A, Simonsen A, van Gils M, Waldemar G, Soininen H, Lötjönen J, Alzheimer's Disease Neuroimaging, Initiative (2011) A disease state fingerprint for evaluation of Alzheimer's disease. J Alzheimers Dis 27, 163-176.
13. Mattila J, Soininen H, Koikkalainen J, Rueckert D, Wolz R, Waldemar G, Lötjönen J (2012) Optimizing the diagnosis of early Alzheimer's disease in mild cognitive impairment subjects. J Alzheimers Dis 32, 969-979.
14. Munõz-Ruiz MA, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka SK, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H (2013) Disease State Fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment. J Alzheimers Dis 35, 727-739.
15. Visser PJ, Verhey FR, Boada M, Bullock R, De Deyn PP, Frisoni GB, Frolich L, Hampel H, Jolles J, Jones R, Minthon L, Nobili F, Olde Rikkert M, Ousset PJ, Rigaud AS, Scheltens P, Soininen H, Spiru L, Touchon J, Tsolaki M, Vellas B, Wahlund LO, Wilcock G, Winblad B (2008) Development of screening guidelines and clinical criteria for predementia Alzheimer's disease. The DESCRIPA Study. Neuroepidemiology 30, 254-265.
16. Mueller SG, Weiner MW, Thal LJ, Petersen RC, Jack C, Jagust W, Trojanowski JQ, Toga AW, Beckett L (2005) The Alzheimer's disease neuroimaging initiative. Neuroimaging Clin N Am 15, 869-877.
17. Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, Morris JC, Petersen RC, Saykin AJ, Schmidt ME, Shaw L, Shen L, Siuciak JA, Soares H, Toga AW, Trojanowski JQ, Alzheimer's Disease Neuroimaging, Initiative (2013) The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimers Dement 9, e111-e194.
18. Lovestone S, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M, AddNeuroMed, Consortium (2009) AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer's disease. Ann N Y Acad Sci 1180, 36-46.
19. Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, Hallikainen M, Kivipelto M, Tervo S, Vanninen R, Evans A, Soininen H (2009) Cortical thickness analysis to detect progressive mild cognitive impairment: A reference to Alzheimer's disease. Dement Geriatr Cogn Disord 28, 404-412.
20. Julkunen V, Niskanen E, Koikkalainen J, Herukka SK, Pihlajam äki M, Hallikainen M, Kivipelto M, Muehlboeck S, Evans AC, Vanninen R, Hilkka, Soininen (2010) Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: A longitudinal study. J Alzheimers Dis 21, 1141-1151.
21. Hänninen T, Hallikainen M, Tuomainen S, Vanhanen M, Soininen H (2002) Prevalence of mild cognitive impairment: A population-based study in elderly subjects. Acta Neurol Scand 106, 148-154.
22. Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A (2001) Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study. BMJ 322, 1447-1451.
23. Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala EL, Vainio P, Vanninen R, Partanen K, Soininen H (2004) Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging 25, 303-310.
24. Herukka SK, Pennanen C, Soininen H, Pirttilä T (2008) CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. J Alzheimers Dis 14, 51-57. Erratum in: J Alzheimers Dis 15, 347.
25. Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, Thompson PM, Stein JL, Moore JH, Farrer LA, Green RC, Bertram L, Jack CR Jr, Weiner MW, Alzheimer's Disease Neuroimaging, Initiative (2010) Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement 6, 265-273.
26. Liu Y, Paajanen T, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H, AddNeuroMed, Consortium (2010) Effect of APOE ε4 allele on cortical thicknesses and volumes: The AddNeuroMed study. J Alzheimers Dis 21, 947-966.
27. Norberg J, GraffC, Almkvist O, Ewers M, Frisoni GB, Frölich L, Hampel H, Jones RW, Kehoe PG, Lenoir H, Minthon L, Nobili F, Olde Rikkert M, Rigaud AS, Scheltens P, Soininen H, Spiru L, Tsolaki M, Wahlund LO, Vellas B, Wilcock G, Elias-Sonnenschein LS, Verhey FR, Visser PJ (2011) Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects. Dement Geriatr Cogn Disord 32, 135-142.
28. Tsukamoto K, Watanabe T, Matsushima T, Kinoshita M, Kato H, Hashimoto Y, Kurokawa K, Teramoto T (1993) Determination by PCR-RFLP of apo E genotype in a Japanese population. J Lab Clin Med 121, 598-602.
29. Simmons A, Westman E, Muehlboeck S, Mecocci P, Vellas B, Tsolaki M, Kłstrokoszewska I, Wahlund LO, Soininen H, Lovestone S, Evans A, Spenger C, AddNeuroMed, Consortium (2009) MRI measures of Alzheimer's disease and the AddNeuroMed study. Ann N Y Acad Sci 1180, 47-55.
30. Jack CR Jr, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, Whitwell LJ, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J, WeinerMW(2008) The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging 27, 685-691.
31. Lötjönen J, Wolz R, Koikkalainen J, Julkunen V, Thurfjell L, Lundqvist R, Waldemar G, Soininen H, Rueckert D, Alzheimer's Disease Neuroimaging, Initiative (2011) Fast and robust extraction of hippocampus from MR images for diagnostics of Alzheimer's disease. Neuroimage 56, 185-196.
32. Heckemann R, Hajnal R, Aljabar P, Rueckert D, Hammers A (2006) Automatic anatomical brain MRI segmentation combining label propagation and decision fusion. Neuroimage 33, 115-126.
33. Hammers A, Allom R, Koepp MJ, Free SL, Myers R, Lemieux L, Mitchell TN, Brooks DJ, Duncan JS (2003) Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 19, 224-247.
34. Gousias IS, Rueckert D, Heckemann RA, Dyet LE, Boardman JP, Edwards AD, Hammers A (2008) Automatic segmentation of brain MRIs of 2-year-olds into 83 regions of interest. Neuroimage 40, 672-684.
35. Munõz-Ruiz MA, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka SK, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H (2012) Structural MRI in frontotemporal dementia: Comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry. PLoS One 7, e52531.
36. Koikkalainen J, Pölönen H, Mattila J, van Gils M, Soininen H, Lötjönen J (2012) Improved classification of Alzheimer's disease data via removal of nuisance variability. PLoS One 7, e31112.
37. Clerx L, van Rossum IA, Burns L, Knol DL, Scheltens P, Verhey F, Aalten P, Lapuerta P, van de Pol L, van Schijndel R, de Jong R, Barkhof F, Wolz R, Rueckert D, Bocchetta M, Tsolaki M, Nobili F, Wahlund LO, Minthon L, Frölich L, Hampel H, Soininen H, Visser PJ (2013) Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment. Neurobiol Aging 34, 2003-2013.
38. Chincarini A, Bosco P, Gemme G, Esposito M, Rei L, Squarcia S, Bellotti R, Minthon L, Frisoni G, Scheltens P, Frölich L, Soininen H, Visser PJ, Nobili F, Alzheimer's Disease Neuroimaging, Initiative (2013) Automatic temporal lobe atrophy assessment in prodromal AD: Data from the DESCRIPA study. Alzheimers Dement 10, 456-467.
39. Aguilar C, Westman E, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Spenger C, Simmons A, Wahlund LO (2013) Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment. Psychiatry Res 212, 89-98.
40. Nordlund A, Rolstad S, Hellström P, Sjögren M, Hansen S, Wallin A (2005) The Goteborg MCI study: Mild cognitive impairment is a heterogeneous condition. J Neurol Neurosurg Psychiatry 76, 1485-1490.
41. Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, van der Flier WM, Blankenstein MA, Ewers M, Rich K, Kaiser E, Verbeek M, Tsolaki M, Mulugeta E, Rosèn E, Aarsland D, Visser PJ, Schröder J, Marcusson J, de Leon M, Hampel H, Scheltens P, Pirttilä T, Wallin A, Jönhagen ME, Minthon L, Winblad B, Blennow K (2009) CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA302, 385-393.
42. Munõz-RuizMA, Hall A, Mattila J, Koikkalainen J, Herukka SK, Vanninen R, Liu Y, Lötjönen J, Soininen H (2014) Comparing predictors of conversion to Alzheimer's disease using the disease state index. Neurodegener Dis 13, 200-202.
43. Vos S, van Rossum I, Burns L, Knol D, Scheltens P, Soininen H, Wahlund LO, Hampel H, Tsolaki M, Minthon L, Handels R, L'Italien G, van der FlierW, Aalten P, Teunissen C, Barkhof F, BlennowK, Wolz R, Rueckert D, Verhey F, Visser PJ (2012) Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI. Neurobiol Aging 33, 2272-2281.
44. Hansson O, ZetterbergH, Buchhave P, Londos E, BlennowK, Minthon L (2006) Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study. Lancet Neurol 5, 228-234.
45. Zetterberg H, Wahlund LO, Blennow K (2003) Cerebrospinal fluid markers for prediction of Alzheimer's disease. Neurosci Lett 352, 67-69.
46. Ashford JW, Schmitt FA (2001) Modeling the time-course of Alzheimer dementia. Curr Psychiatry Rep 3, 20-28.
47. Liu Y, Julkunen V, Paajanen T, Westman E, Wahlund LO, Aitken A, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H, AddNeuroMed Consortium (2012) Education increases reserve against Alzheimer's disease-evidence from structural MRI analysis. Neuroradiology 54, 929-938.
48. Raber J, Huang Y, Ashford JW (2004) ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging 25, 641-650.
49. Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K (2011) The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement 7, 386-395.
50. Mattsson N, Zetterberg H, Blennow K (2010) Lessons from multicenter studies on CSF biomarkers for Alzheimer's disease. Int J Alzheimers Dis 2010, pii: 610613.
51. Westman E, Simmons A, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Weiner MW, Lovestone S, Spenger C, Wahlund LO, AddNeuroMed consortium, Alzheimer's Disease Neuroimaging, Initiative (2011) AddNeuroMed and ADNI: Similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America. Neuroimage 58, 818-828.
52. Stonnington CM, Tan G, Klöppel S, Chu C, Draganski B, Jack CR Jr, Chen K, Ashburner J, Frackowiak RS (2008) Interpreting scan data acquired from multiple scanners: A study with Alzheimer's disease. Neuroimage 39, 1180-1185.
53. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger- Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746.
54. Petersen R, Aisen P, Boeve B, Geda Y, Ivnik R, Knopman D, Mielke M (2013) Mild Cognitive Impairment Due to Alzheimer Disease in the Community. Ann Neurol 74, 199-208.
55. Esposito R, Mosca A, Pieramico V, Cieri F, Cera N, Sensi SL (2013) Characterization of resting state activity in MCI individuals. PeerJ 1, e135.
56. Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H, AddNeuroMed, Consortium (2010) APOE ε2 allele is associated with larger regional cortical thicknesses and volumes. Dement Geriatr Cogn Disord 30, 229-237.
57. Christa Maree Stephan B, Minett T, Pagett E, Siervo M, Brayne C, McKeith IG (2013) Diagnosing mild cognitive impairment (MCI) in clinical trials:Asystematic review. BMJ Open 3, pii: e001909.
58. Palmqvist S, Hertze J, Minthon L, Wattmo C, Zetterberg H, Blennow K, Londos E, Hansson O (2012) Comparison of brief cognitive tests and CSF biomarkers in predicting Alzheimer's disease in mild cognitive impairment: Six-year follow-up study. PLoS One 7, e38639.
59. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC (2004) Mild cognitive impairment - beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256, 240-246.
60. Galluzzi S, Geroldi C, Amicucci G, Bocchio-Chiavetto L, Bonetti M, Bonvicini C, Cotelli M, Ghidoni R, Paghera B, Zanetti O, Frisoni GB, Translational Outpatient Memory ClinicWorking, Group (2013) Supporting evidence for using biomarkers in the diagnosis of MCI due to AD. J Neurol 260, 640-650.