Plants used to treat snakebites in Santarém, western Pará, Brazil: An assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom

Journal of Ethnopharmacology

Volumn 161, Issue , 2015, Pages 224-232

  De Moura, Valéria Mourão ^a,b   Freitas De Sousa, Luciana A ^a   Cristina Dos Santos, Maria ^b   Almeida Raposo, Juliana Divina ^a   Evangelista Lima, Aline ^a   De Oliveira, Ricardo Bezerra ^a   Da Silva, Milton Nascimento ^c   Veras Mourão, Rosa Helena ^a  

^a UNIVERSIDADE FEDERAL DO OESTE DO PARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

^c FEDERAL UNIVERSITY OF PARÁ   (Brazil)

Author keywords

Anti snakebite plants; Ethnobotany; Hemorrhage; Plant extracts; Snakebite envenomation

Indexed keywords

BATROXOBIN; FLAVONOID; PLANT EXTRACT; SNAKE VENOM ANTISERUM; TANNIN DERIVATIVE; PLANT MEDICINAL PRODUCT; SNAKE VENOM; VENOM ANTISERUM;

ANIMAL EXPERIMENT; ARTICLE; BARK; BELLUCIA DICHOTOMA; BLEEDING; BOTHROPS JARARACA; BRAZIL; CLINICAL ASSESSMENT; COLORIMETRY; CONNARUS FAVOSUS; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; JUSTICIA PECTORALIS; MALE; MOUSE; NONHUMAN; OPEN ENDED QUESTIONNAIRE; PHILODENDRON MEGALOPHYLLUM; PLANT LEAF; PLANT SEED; PLATHYMENIA RETICULATA; POLYACRYLAMIDE GEL ELECTROPHORESIS; QUESTIONNAIRE; SNAKEBITE; THIN LAYER CHROMATOGRAPHY; TINCTURE; TRADITIONAL MEDICINE; WESTERN BLOTTING; ADULT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; BOTHROPS; CHEMISTRY; HEMORRHAGE; HUMAN; MEDICINAL PLANT; MIDDLE AGED; PHYTOTHERAPY; SNAKE BITES; VERY ELDERLY;

BOTHROPS JARARACA;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIVENINS; BOTHROPS; BRAZIL; CROTALID VENOMS; FEMALE; HEMORRHAGE; HUMANS; MALE; MEDICINE, TRADITIONAL; MICE; MIDDLE AGED; PHYTOCHEMICALS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; SNAKE BITES;

EID: 84920854940     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.12.020     Document Type: Article

References (48)

1. Ambikabothy, J., Ibrahim, H., Ambu, S., Chakravarthi, S., Awang, K., Vejayan, J., 2011. Efficacy evaluations of Mimosa pudica tannin isolate (MPT) for its anti-ophidian properties. Journal of Ethnopharmacology 137, 257-262.
2. Araújo, F.A.A., Santalúcia, M., Cabral, R.F., 2003. Epidemiologia dos acidentes por animais pec¸onhentos. In: Cardoso, J.L.C., Franc¸a, F.O.S., Wen, F.H., Malaque, C.M.S., Haddad Junior, V (Eds.), Animais pec¸onhentos no Brasil: biologia, clínica e terapêutica dos acidentes. Sarvier, São Paulo, SP, pp. 6-12.
3. Bjarnason, J.B., Fox, J.M., 1995. Snake venom metalloendopeptidases: reprolysins. Methods in Enzimology 248, 345-368.
4. Baldo, C., Jamora, C., Yamanouye, N., Zorn, T.M., Moura-da-Silva, A.M., 2010. Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis. PLoS Neglected Tropical Diseases 4, e727.
5. Bochner, R., Struchiner, C., 2003. Snakebite epidemiology in the last 100 years in Brazil: a rewiew. Cadernos de Saúde Pública 19, 7-16.
6. Borges, C.C., Cavalcanti-Neto, A.J., Boechat, A.L., Francisco, C.H., Arruda, M.R.E., Dos- Santos, M.C., 1996. Eficácia da espécie vegetal Peltodon radicans (Labiatae, Lameaceae) na neutralizac¸ão da atividade edematogênica e ineficácia do extrato vegetal Específico Pessoa na neutralizac¸ão das principais atividades do veneno de Bothrops atrox. Revista da Universidade do Amazonas, 1. Ciências Biológicas, Série, pp. 97-113.
7. Borges, C.C., Sadahiro, M., Dos-Santos, M.C., 1999. Aspectos epidemiológicos e clínicos dos acidentes ofídicos ocorridos nos municípios do Estado do Amazonas. Revista da Sociedade Brasileira de Medicina Tropical 32, 637-646.
8. Cardoso, J.L.C., Franc¸a, F.O.S., Wen, F.H., Málaque, S.A., Haddad, V.J., 2003. Animais Pec¸onhentos No Brasil: Biologia, Clínica e Terapêutica dos acidentes. Editora Sarvier, São Paulo.
9. Castro, O., Gutiérrez, J.M., Barrios, M., Castro, I., Romero, M., Umaña, E., 1999. Neutralizacíón Del efecto hemorrágico inducido por veneno de Bothrops asper (Serpentes: Viperidae) por extractos de plantas tropicales. Revista de Biologia Tropical 47, 605-616.
10. Castro, K.N.C., Carvalho, A.L.O., Almeida, A.P., Oliveira, D.B., Borba, H.R., Costa, S.S., Zingali, R.B., 2003. Preliminary in vitro studies on the Marsypianthes chamaedrys (boia-caá) extracts at fibrinoclotting induced by snake venoms. Toxicon 41, 929-932.
11. Chabariberi, R.A.O., Pozzi, A.C.S., Zeraik, M.L., Yariwake, J.H., 2009. Determinac¸ão espectrométrica dos flavonoides das folhas de Maytenus (Celastraceae) e de Passiflora (Passifloraceae) e comparac¸ão com método CLAE-UV. Brazilian Journal of Pharmacognosy 19, 860-864.
12. Da Silva, J.O., Fernandes, R.S., Ticli, F.K., Oliveira, C.Z., Mazzi, M.V., Franco, J.J., Giuliatt, S, Pereira, P.S., Soares, A.M., Sampaio, S.V., 2007. Triterpenoid saponins, new metalloproteinase snake venom inhibitors isolated from Pentaclethra macroloba. Toxicon 50, 283-291.
13. Dougherty, E.R., 2002. Foundations of Morphological Image Processing. In: J.P., Hornak (Ed.), Encyclopedia of Imaging Science and Technology. John Wiley, New York.
14. Dougherty, E.R., Lotufo, R.A., 2003. Hands-on Morphological Image Processing. SPIE Press, College Station, TX, USA/Campinas, SP, Brazil.
15. Farrapo, N.M., Silva, G.A.A., Costa, K.N., Silva, M.G., Cogo, J.C., Dal Belo, C.A., Santos, M.G., Groppo, F.C., Oshima-Franco, Y., 2011. Inhibition of Bothrops jararacussu venom activities by Plathymenia reticulata Benth extracts. Journal of Venom Research 2, 52-58.
16. Fonseca, F.V., Melo, M.M., Silva, J., Pereira, G.P., Dantas-Barros, AM., 2004. Extratos de Curcuma longa L. e Kalanchoe brasiliensis Camb. no tratamento local do envenenamento por Bothrops alternatus. Revista Brasileira de Farmacognosia 14, 26-29.
17. Fox, J.W., Serrano, S.M., 2008. Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity. The FEBS Journal 275, 3016-3030.
18. Gonzalez, R.C., Woods, R.E., Eddins, S,L., 2009. Digital Image Processing Using MATLAB, 2nd ed. Gatesmark Publishing, Knoxville, TN.
19. Guerra, C.E., Xavier, A.R., Andrade, A.J.N., 2011. Watershed Threshold and gray level morfology applied to object detecting in remote sensing and petrographics images. In: Proceedings of the 12th International Congress of the Brazilian Geophysical Society in Rio de Janeiro, Brazil.
20. Gutiérrez, J.M., León, G., Rojas, G., Lomonte, B., Rucavado, A., Chaves, F., 1998. Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom. Toxicon 36, 1529-1538.
21. Hagerman, A.E., Rice, M.E., Ritchard, N.T., 1998. Mechanisms of protein precipitation for two tannins, pentagalloyl glucose and epicatechin16(4- > 8) catechin (procyanidin). Journal of Agriculture and Food Chemistry 46, 2590-2595.
22. Haslam, E, 1996. Natural polyphenols (vegetable tannins) as drugs: possible modes of action. Journal of Natural Products 59, 205-215.
23. Kasturiratne, A., Wickremasinghe, A.R., Silva, N., Gunawardena, N.K., Pathmeswaran, A., Premaratna, R., Savioli, L., Lalloo, D.G., Silva, H.J., 2008. The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Medicine 5, 1591-1604.
24. Krishnan, S.A., Dileepkumar, R., Nair, A.S., Oommen, O.V., 2014. Studies on neutralizing effect of Ophiorrhiza mungos root extract against Daboia russelii venom. Journal of Ethnopharmacology 151, 543-547.
25. Kondo, H.S., Ikezawa, R., Murata, A., Ohsaka, 1960. Studies on the quantitative method for determination of hemorrhagic activity of Habu snake venom. Japanese Journal of Medical Science & Biology 13, 43-51.
26. Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
27. Magalhães, A., Santos, G.B., Verdam, M.C.S., Fraportid, L., Malheiro, A., Lima, E.M., Dos-Santos, M.C., 2011. Inhibition of the inflammatory and coagulant action of Bothrops atrox venom by the plant species Marsypianthes chamaedrys. Journal of Ethnopharmacology 134, 82-88.
28. Marini-Bettolo, G.B., Nicoletti, M., Patamia, M., 1981. Plant screening by chemical and chromatographic procedures under field conditions. Journal of Chromatography A 213, 113-127.
29. Mcnabb, W.C., Peters, J.S., Foo, L.Y., Waghorn, G.C., Jackson, S.J., 1998. Effect of condensed tannins prepared from several forages on the in vitro precipitation of ribulose-1,5-bisphospathe carboxilase (rubisco) protein and its digestion by trypsin (EC 2.4.21.4) and chymotrypsin (EC 2.4.21.1). Journal of the Science of Food and Agriculture 77, 201-212.
30. Ministério da Saúde, 2010. Doenc¸as infecciosas e parasitárias: Guia de bolso/Ministério da Saúde, Secretaria de Vigilância de Saúde (444 pp.). 8th ed. Departamento de Vigilância Epidemiológica, Brasília.
31. Ministério da Saúde, 2005. Guia de Vigilância Epidemiológica/Ministério da Saúde (816 pp.). 6th ed. Secretaria de Vigilância em Saúde, Brasília.
32. Mole, S., Waterman, P.G., 1987a. A critical analysis of techniques for measuring tannins in ecological studies I. Techniques for chemically defining tannins. Oecologia 72, 137-156.
33. Mole, S., Waterman, P.G., 1987b. A critical analysis of techniques for measuring tannins in ecological studies II. Techniques of biochemically defining tannins. Oecologia 72, 148-156.
34. Mors, W.B., Nascimento, M.C., Pereira, B.M.R., Pereira, N.A., 2000. Plant natural products active against snakebite the molecular approach. Phytochemistry 55, 627-642.
35. Moura, V.M., Mourão, R.H.V., 2012. Aspectos do ofidismo no Brasil e plantas medicinais utilizadas como complemento à soroterapia. Scientia Amazonia 1, 17-26.
36. Moura, V.M., Sousa, L.A.F., Oliveira, R.B., Moura-da-Silva, A.M., Chalkidis, H.M., Silva, M.N., Pacheco, S., Mourão, R.H.V., 2013. Inhibition of the principal enzymatic and biological effects of the crude venom of Bothrops atrox by plant extracts. Journal of Medicinal Plant Research 7, 2330-2337.
37. Moura, V.M., Bezerra, A.N.S., Mourão, R.H.V., Lameiras, J.L.V., Raposo, J.D.A., Sousa, R. L., Boechat, A.L., Oliveira, R.B., Chalkidis, H.M., Dos-Santos, M.C., 2014. A comparison of the ability of Bellucia dichotoma Cogn. (Melastomataceae) extract to inhibit the local effects of Bothrops atrox venom when pre-incubated and when used according to traditional methods. Toxicon 85, 59-68.
38. Otero, R., Fonnegra, R., Jiménez, S.L., Núñez, V., Evans, N., Alzate, S.P., García, M.E., Saldarriaga, M., Del Valle, G., Osorio, R.G., Díaz, A., Valderrama, R., Duque, A., Vélez, H.N., 2000. Snakebites and ethnobotany in the northwest region of Colombia part I: traditional use of plants. Journal of Ethnopharmacology 71, 493-504.
39. Sia, F.Y., Vejayan, J., Jamuna, A., Ambu, S., 2011. Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom. The Journal of Venomous Animals and Toxins including Tropical Diseases 17, 42-48.
40. Sistema de Informac¸ão de Agravos de Notificac¸ão- SINAN, 2013. Acidentes por Animais Pec¸onhentos. Available: http://dtr2004.saude.gov.br/sinanweb/ (accessed 10.08.14).
41. Sousa, L.A.F., Moura, V.M., Raposo, J.D.A., Sousa, L.F., Oliveira, R.B., Santos, L.S., Araújo, R.N.M., Moura-da-Silva, A.M., Aranha, E.P., Suemitsu, C., Guerra, C.E., Chalkidis, H.M., Pacheco, S., Mourão, R.H.V., 2013. The effect of the aqueous extract of Myrcia guianensis (AubL) DC and its fractions against the hemorrhagic activity of Bothrops jararaca venom. Journal of Medicinal Plants Research 7, 3139-3146.
42. Sun, B., Ricardo-da-Silva, J.M., Spranger, I., 1998. Critical Factors of Vanillin Assay for Catechins and Proanthocyanidins. J. Agric. Food Chem. 46, 4267-4274.
43. Vásquez, J., Jimenéz, S.L., Goméz, I.C., Rey, J.P., Henao, A.M., Marín, D.M., Romero, J. O., Alarcón, J.C., 2013. Snakebites and ethnobotany in the Eastern region of Antioquia, Colombia: the traditional use of plants. Journal of Ethnopharmacology 146, 449-455.
44. Vilar, J.C., Carvalho, C.M., Furtado, M.F.D., 2005. Ofidismo e plantas utilizadas como antiofídicas. Biologia Geral e Experimental 6, 3-36.
45. Warrell, D.A., 1992. The global problem of snake bite: its prevention and treatment. In: Gopalakrishnaakone, P, Tu, CK (Eds.), Recent Advances in Toxinology Research. National University of Singapore Publishers, Singapore, pp. 121-153.
46. Willis, R.B., Allen, P.R., 1998. Improved method for measuring hydrolyzable tannins using potassium iodate. Analyst 123, 435-439.
47. WHO, 2007. Rabies and envenomings. A neglected public health issue. Available: 〈http://whqlibdoc.who.int/publications/2007/9789241563482-eng.pdf〉 (accessed 18.08.14).
48. WHO, 2009. Snakebite. Available: 〈http://www.who.int/neglected-diseases/diseases/snakebites/en/index.html〉 (accessed 15.09.14).