The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Fan, Jia Dong ^a   Lei, Pin Ji ^a   Zheng, Jun Yi ^a   Wang, Xiang ^a   Li, Shangze ^a   Liu, Huan ^a   He, Yi Lei ^a   Wang, Zhao Ning ^a   Wei, Gang ^b   Zhang, Xiaodong ^a   Li, Lian Yun ^a   Wu, Min ^a  

^a WUHAN UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS RELATED CELL DEATH PROTEIN; CELL PROTEIN; ETOPOSIDE; FLUCYTOSINE DEOXYRIBOSIDE; FLUOROURACIL; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; LC3B PROTEIN; MESSENGER RNA; METHYLTRANSFERASE; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; PLACEBO; PROTEIN P21; PROTEIN P53; PROTEIN SMYD2; PUMA PROTEIN; RAPAMYCIN; TUMOR PROTEIN P53 INDUCIBLE NUCLEAR PROTEIN 2; UNCLASSIFIED DRUG; ATG4A PROTEIN, HUMAN; ATG9A PROTEIN, HUMAN; AZEPINE DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYSTEINE PROTEINASE; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; MAP1LC3A PROTEIN, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; QUINAZOLINE DERIVATIVE; SMALL INTERFERING RNA; SMYD2 PROTEIN, HUMAN; TRANSCRIPTOME; VESICULAR TRANSPORT PROTEIN;

APOPTOSIS; ARTICLE; ATG4A GENE; ATG9A GENE; AUTOPHAGY; BIOACCUMULATION; CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG TARGETING; GENE; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE TARGETING; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; KNOCKOUT GENE; OPEN READING FRAME; P53 GENE; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMYD2 GENE; TRANSCRIPTION REGULATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; HCT116 CELL LINE; METABOLISM; METHYLATION; RNA INTERFERENCE; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; AZEPINES; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYSTEINE ENDOPEPTIDASES; HCT116 CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; MEMBRANE PROTEINS; METHYLATION; MICROTUBULE-ASSOCIATED PROTEINS; QUINAZOLINES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIROLIMUS; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEIN P53; VESICULAR TRANSPORT PROTEINS;

EID: 84920854860     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116782     Document Type: Article

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