Epithelial cell adhesion molecule aptamer conjugated PEG-PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line in vitro

International Journal of Pharmaceutics

Volumn 479, Issue 1, 2015, Pages 241-251

  Alibolandi, Mona ^a   Ramezani, Mohammad ^a,b   Sadeghi, Fatemeh ^a,c   Abnous, Khalil ^b   Hadizadeh, Farzin ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aptamer; EpCAM; Nanopolymersomes; PEG PLGA; Targeted drug delivery

Indexed keywords

APTAMER; DOXORUBICIN; EPITHELIAL CELL ADHESION MOLECULE; MACROGOL; POLYGLACTIN; ANTINEOPLASTIC AGENT; CELL ADHESION MOLECULE; EPCAM PROTEIN, HUMAN; MACROGOL DERIVATIVE; NANOPARTICLE; POLYESTER; POLYETHYLENE GLYCOL-POLY(LACTIDE-CO-GLYCOLIDE); TUMOR ANTIGEN;

ADENOCARCINOMA CELL LINE; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CELL TRANSPORT; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INTERNALIZATION; MCF 7 CELL LINE; MOLECULARLY TARGETED THERAPY; NANOENCAPSULATION; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADENOCARCINOMA; BREAST TUMOR; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ADENOCARCINOMA; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; APTAMERS, NUCLEOTIDE; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HUMANS; NANOPARTICLES; POLYESTERS; POLYETHYLENE GLYCOLS;

EID: 84920767904     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.12.035     Document Type: Article

References (59)

1. Ahmed, F., Discher, D.E., 2004. Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles. J. Control. Release 96, 37-53.
2. Amin, M., Badiee, A., Jaafari, M.R., 2013. Improvement of pharmacokinetic and antitumor activity of PEGylated liposomal doxorubicin by targeting with N-methylated cyclic RGD peptide in mice bearing C-26 colon carcinomas. Int. J. Pharm. 458, 324-333. doi:http://dx.doi.org/10.1016/j.ijpharm.2013.10.018.
3. Bolotin, et al., 1999. Liposomal Bupivacaine compositions prepared using an ammonium sulfate gradient, U.S. Patent, No. 6162462.
4. Chai, C., Xie, Z., Grotewold, E., 2011. SELEX (systematic evolution of ligands by exponential enrichment), as a powerful tool for deciphering the protein-DNA interaction space. Methods Mol. Biol. 754, 249-258. doi:http://dx.doi.org/10.1007/978-1-61779-154-3-14.
5. Chen, H., Zhao, J., Zhang, M., Yang, H., Ma, Y., Gu, Y., 2014. MUC1 aptamer-based near-infrared fluorescence probes for tumor imaging. Mol. Imaging Biol..
6. Cheng, J., Teply, B.A., Sherifi, I., Sung, J., Luther, G., Gu, F.X., Levy-Nissenbaum, E., Radovic-Moreno, A.F., Langer, R., Farokhzad, O.C., 2007. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 28, 869-876.
7. Chiang, W.H., Huang, W.C., Chang, C.W., Shen, M.Y., Shih, Z.F., Huang, Y.F., Lin, S.C., Chiu, H.C., 2013. Functionalized polymersomes with outlayered polyelectrolyte gels for potential tumor-targeted delivery of multimodal therapies and MR imaging. J. Control. Release 168, 280-288. doi:http://dx.doi.org/10.1016/j.jconrel.2013.03.029.
8. Cho, B., 2015. RNA-RNA selex. Methods Mol. Biol.1240, 39-47. doi:http://dx.doi.org/10.1007/978-1-4939-1896-6-3.
9. Das, M., Duan, W., Sahoo, S.K., 2014. Multifunctional nanoparticle-EpCAM aptamer bioconjugates: a paradigm for targeted drug delivery and imaging in cancer therapy. Nanomedicine 525 pii: S1549-9634(14) 525-5, doi: 10.1016/j.nano.2014.09.002.
10. Dassie, J.P., Hernandez, L.I., Thomas, G.S., Long, M.E., Rockey, W.M., Howell, C.A., Chen, Y., Hernandez, F.J., Liu, X.Y., Wilson, M.E., Allen, L.A., Vaena, D.A., Meyerholz, D.K., Giangrande, P.H., 2014. Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen. Mol. Ther. 22, 1910-1922. doi:http://dx.doi.org/10.1038/mt.2014.117.
11. Discher, D.E., Eisenberg, A., 2002. Polymer vesicles. Science 297, 967-973.
12. Discher, B.M., Won, Y.Y., Ege, D.S., Lee, J.C.M., Bates, F.S., Discher, D.E., D.A, Hammer, 1999. Polymersomes: tough vesicles made from diblock copolymers. Science 284, 1143-1146.
13. Fong, D., Seeber, A., Terracciano, L., Kasal, A., Mazzoleni, G., Lehne, F., Gastl, G., Spizzo, G., 2014. Expression of EpCAM(MF) and EpCAM(MT) variants in human carcinomas. J. Clin. Pathol. 67, 408-414. doi:http://dx.doi.org/10.1136/jclinpath-2013-201932.
14. Fu, Y., Kao, W.J., 2010. Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems. Expert Opin. Drug Deliv. 7, 429-444.
15. Gan, C.W., Chien, S., Feng, S.S., 2010. Nanomedicine enhancement of chemotherapeutical efficacy of docetaxel by using a biodegradable nanoparticle formulation. Curr. Pharm. Des. 16, 2308-2320.
16. Gires, O., Stoecklein, N.H., 2014. Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences. Cell. Mol. Life Sci. 71, 4393-4402.
17. Iversen, T.G., Skotland, T., Sandvig, K., 2011. Endocytosis and intracellular transport of nanoparticles: present knowledge and need for future studies. Nano Today 6, 176-185.
18. Jayasena, S.D., 1999. Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin. Chem. 45, 1628-1650.
19. Lale, S.V., RGA, Aravind, A., Kumar, D.S., Koul, V., 2014. AS1411 aptamer and folic acid functionalized pH-responsive ATRP fabricated pPEGMA-PCL-pPEGMA polymeric nanoparticles for targeted drug delivery in cancer therapy. Biomacromolecules 15, 1737-1752. doi:http://dx.doi.org/10.1021/bm5001263.
20. Levacheva, I., Samsonova, O., Tazina, E., Beck-Broichsitter, M., Levachev, S., Strehlow, B., Baryshnikova, M., Oborotova, N., Baryshnikov, A., Bakowsky, U., 2014. Optimized thermosensitive liposomes for selective doxorubicin delivery: formulation development, quality analysis and bioactivity proof. Colloids Surf. B 121, 248-256.
21. Li, X., Yu, Y., Ji, Q., Qiu, L., 2014a. Targeted delivery of anticancer drugs by aptamer AS1411 mediated Pluronic F127/cyclodextrin-linked polymer composite micelles. Nanomedicine 436 pii: S1549-9634(14) 436-5, doi: 10.1016/j.nano.2014.08.013.
22. Li, W., Chen, H., Yu, M., Fang, J., 2014b. Targeted delivery of doxorubicin using a colorectal cancer-specific ssDNA aptamer. Anat. Rec. (Hoboken) doi:http://dx.doi.org/10.1002/ar.22990.
23. Li, L., Xiang, D., Shigdar, S., Yang, W., Li, Q., Lin, J., Liu, K., Duan, W., 2014c. Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. Int. J. Nanomed. 9, 1083-1096. doi:http://dx.doi.org/10.2147/IJN.S59779.
24. Li, J., You, J., Dai, Y., Shi, M., Han, C., Xu, K., 2014d. Gadolinium oxide nanoparticles and aptamer-functionalizedsilvernanoclusters-basedmultimodalmolecularimaging nanoprobe for optical/magnetic resonance cancer cell imaging. Anal. Chem..
25. Litvinov, S.V., Balzar, M., Winter, M.J., Bakker, H.A., Briaire-de Bruijn, I.H., Prins, F., Fleuren, G.J., Warnaar, S.O., 1997. Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J. Cell Biol. 139, 1337-1348.
26. Liu, Z., Duan, J.H., Song, Y.M., Ma, J., Wang, F.D., Lu, X., Yang, X.D., 2012. Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro. J. Transl. Med. 10, 148. doi:http://dx.doi.org/10.1186/1479-5876-10-148.
27. Lu, J., Zhao, W., Huang, Y., Liu, H., Marquez, R., Gibbs, R.B., Li, J., Venkataramanan, R., Xu, L., Li, S., Li, S., 2014. Targeted delivery of doxorubicin by folic acid-decorated dual functional nanocarrier. Mol. Pharmaceutics 11, 4164-4178. doi:http://dx.doi.org/10.1021/mp500389v.
28. Münz, M., Murr, A., Kvesic, M., Rau, D., Mangold, S., Pflanz, S., Lumsden, J., Volkland, J., Fagerberg, J., Riethmüller, G., Rüttinger, D., Kufer, P., Baeuerle, P.A., Raum, T., 2010. Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies. Cancer Cell Int. 10, 44. doi:http://dx.doi.org/10.1186/1475-2867-10-44.
29. Magenheim, B., Levy, M.Y., Benita, S.,1993. A new in vitro technique for evaluation of drug release profile from colloidal carriers-ultrafiltration technique at low pressure. Int. J. Pharm. 94, 115-123.
30. Massoner, P., Thomm, T., Mack, B., Untergasser, G., Martowicz, A., Bobowski, K., Klocker, H., Gires, O., Puhr, M., 2014. EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205. Br. J. Cancer 111, 955-964. doi:http://dx.doi.org/10.1038/bjc.2014.366.
31. McConnell, E.M., Holahan, M.R., DeRosa, M.C., 2014. Aptamers as promising molecular recognition elements for diagnostics and therapeutics in the central nervous system. Nucleic Acid Ther. 24 (6), 388-404. doi:http://dx.doi.org/10.1089/nat.2014.0492.
32. Niu, G., Cogburn, B., Hughes, J., 2010. Preparation and characterization of doxorubicin liposomes. Methods Mol. Biol. 624, 211-219. doi:http://dx.doi.org/10.1007/978-1-60761-609-2-14.
33. Oh, S.S., Lee, B.F., Leibfarth, F.A., Eisenstein, M., Robb, M.J., Lynd, N.A., Hawker, C.J., Soh, H.T., 2014a. Synthetic aptamer-polymer hybrid constructs for programmed drug delivery into specific target cells. J. Am. Chem. Soc. 136, 15010-15015. doi:http://dx.doi.org/10.1021/ja5079464.
34. Oh, S.S., Lee, B.F., Leibfarth, F.A., Eisenstein, M., Robb, M.J., Lynd, N.A., Hawker, C.J., Soh, H.T., 2014b. Synthetic aptamer-polymer hybrid constructs for programmed drug delivery into specific target cells. J. Am. Chem. Soc. 136, 15010-15015. doi:http://dx.doi.org/10.1021/ja5079464.
35. Oishi, N., Yamashita, T., Kaneko, S., 2014. Molecular biology of liver cancer stem cells. Liver Cancer 3, 71-84. doi:http://dx.doi.org/10.1159/000343863.
36. Patriarca, C., Macchi, R.M., Marschner, A.K., Mellstedt, H., 2012. Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. Cancer Treat Rev. 38, 68-75. doi:http://dx.doi.org/10.1016/j.ctrv.2011.04.002.
37. Pavšič, M., Gunčar, G., Djinović-Carugo, K., Lenarčič, B., 2014. Crystal structure and its bearing towards an understanding of key biological functions of EpCAM. Nat. Commun. 5, 4764. doi:http://dx.doi.org/10.1038/ncomms5764.
38. Ray, P., Cheek, M.A., Sharaf, M.L., Li, N., Ellington, A.D., Sullenger, B.A., Shaw, B.R., White, R.R., 2012. Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. Nucleic Acid Ther. 22, 295-305. doi:http://dx.doi.org/10.1089/nat.2012.0353.
39. Schulze, K., Gasch, C., Staufer, K., Nashan, B., Lohse, A.W., Pantel, K., Riethdorf, S., Wege, H., 2013. Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma. Int. J. Cancer 133, 2165-2171. doi:http://dx.doi.org/10.1002/ijc.28230.
40. Shahidi-Hamedani, N., Shier, W.T., Moghadam Ariaee, F., Abnous, K., Ramezani, M., 2013. Targeted gene delivery with noncovalent electrostatic conjugates of sgc-8c aptamer and polyethylenimine. J. Gene Med. 15, 261-269. doi:http://dx.doi.org/10.1002/jgm.2718.
41. Shigdar, S., Lin, J., Yu, Y., Pastuovic, M., Wei, M., Duan, W., 2011. RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci. 102, 991-998. doi:http://dx.doi.org/10.1111/j.1349-7006.2011.01897.x.
42. Shigdar, S., Qian, C., Lv, L., Pu, C., Li, Y., Li, L., Marappan, M., Lin, J., Wang, L., Duan, W., 2013. The use of sensitive chemical antibodies for diagnosis: detection of low levels of EpCAM in breast cancer. PLoS One 8 (2), e57613. doi:http://dx.doi.org/10.1371/journal.pone.0057613.
43. Song, Y., Huang, Z., Song, Y., Tian, Q., Liu, X., She, Z., Jiao, J., Lu, E., Deng, Y., 2014. The application of EDTA in drug delivery systems: doxorubicin liposomes loaded via NH4EDTA gradient. Int. J. Nanomed. 9, 3611-3621.
44. Soysal, S.D., Muenst, S., Barbie, T., Fleming, T., Gao, F., Spizzo, G., Oertli, D., Viehl, C.T., Obermann, E.C., Gillanders, W.E., 2013. EpCAM expression varies significantly and is differentially associated with prognosis in the luminal B HER2(+), basal-like, and HER2 intrinsic subtypes of breast cancer. Br. J. Cancer 108, 1480-1487. doi:http://dx.doi.org/10.1038/bjc.2013.80.
45. Subramanian, N., Raghunathan, V., Kanwar, J.R., Kanwar, R.K., Elchuri, S.V., Khetan, V., Krishnakumar, S., 2012. Target-specific delivery of doxorubicin to retinoblastoma using epithelial cell adhesion molecule aptamer. Mol. Vis. 18, 2783-2795.
46. Surovtseva, E.V., Johnston, A.H., Zhang, W., Zhang, Y., Kim, A., Murakoshi, M., Wada, H., Newman, T.A., Zou, J., Pyykkö, I., 2012. Prestin binding peptides as ligands for targeted polymersome mediated drug delivery to outer hair cells in the inner ear. Int. J. Pharm. 424, 121-127. doi:http://dx.doi.org/10.1016/j.ijpharm.2011.12.042.
47. Szeitner, Z., András, J., Gyurcsányi, R.E., Mészáros, T., 2014. Is less more? Lessons from aptamer selection strategies. J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2014.04.018, pii: S0731-7085(14) 209-X..
48. Taghdisi, S.M., Danesh, N.M., Sarreshtehdar Emrani, A., Tabrizian, K., Zandkarimi, M., Ramezani, M., Abnous, K., 2013. Targeted delivery of epirubicin to cancer cells by PEGylated A10 aptamer. J. Drug Targeting 21, 739-744. doi:http://dx.doi.org/10.3109/1061186X.2013.812095.
49. Tan, L., Neoh, K.G., Kang, E.T., Choe, W.S., Su, X., 2011. PEGylated anti-MUC1 aptamer-doxorubicin complex for targeted drug delivery to MCF7 breast cancer cells. Macromol. Biosci. 11, 1315-1331. doi:http://dx.doi.org/10.1002/mabi.201100173.
50. Tan, Y., Liang, H., Wu, X., Gao, Y., Zhang, X., 2013. Cell-ELA-based determination of binding affinity of DNA aptamer against U87-EGFRvIII cell. Sheng Wu Gong Cheng Xue Bao 29, 664-671.
51. Tas, F., Karabulut, S., Duranyildiz, D., 2014. Clinical significance of serum epithelial cell adhesion molecule (EPCAM) levels in patients with lung cancer. Mol. Cell. Biochem. 396, 307-312. doi:http://dx.doi.org/10.1007/s11010-014-2167-3.
52. Wang, H., Zhao, Y., Wu, Y., Hu, Y.L., Nan, K., Nie, G., Chen, H., 2011. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials 32, 8281-8290. doi:http://dx.doi.org/10.1016/j.biomaterials.2011.07.032.
53. Winter, M.J., Cirulli, V., Briaire-de Bruijn, I.H., Litvinov, S.V., 2007. Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinase. Mol. Cell. Biochem. 302, 19-26.
54. Yan, J.K., Ma, H.L., Chen, X., Pei, J.J., Wang, Z.B., Wu, J.Y., 2014. Self-aggregated nanoparticles of carboxylic curdlan-deoxycholic acid conjugates as a carrier of doxorubicin. Int. J. Biol. Macromol. 72C, 333-340.
55. Yoo, H.S., Park, T.G., 2001. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J. Control. Release 70, 63-70.
56. Zhang, L., Radovic-Moreno, A.F., Alexis, F., Gu, F.X., Basto, P.A., Bagalkot, V., Jon, S., Langer, R.S., Farokhzad, O.C., 2007Sep. Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates. ChemMedChem 2, 1268-1271.
57. Zhang, Y., Zhang, W., Johnston, A.H., Newman, T.A., Pyykkö, I., Zou, J., 2012. Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve. Int. J. Nanomed. 7, 1015-1022. doi:http://dx.doi.org/10.2147/IJN.S28185.
58. Zhou, W., Zhou, Y., Wu, J., Liu, Z., Zhao, H., Liu, J., Ding, J., 2014. Aptamer-nanoparticle bioconjugates enhance intracellular delivery of vinorelbine to breast cancer cells. J. Drug Targeting 22, 57-66. doi:http://dx.doi.org/10.3109/1061186X.2013.839683.
59. Zhu, H., Li, J., Zhang, X.B., Ye, M., Tan, W., 2014. Nucleic acid aptamer-mediated drug delivery for targeted cancer therapy. ChemMedChem doi:http://dx.doi.org/10.1002/cmdc.201402312.