Systemic and placental leptin and its receptors in pregnancies associated with obesity

Reproductive Sciences

Volumn 22, Issue 2, 2015, Pages 189-197

  Tsai, Pai Jong Stacy ^a   Davis, James ^a   Bryant Greenwood PhD, Gillian ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

Leptin; Leptin receptor; Obesity; Pregnancy

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; BIOLOGICAL MARKER; LEPTIN RECEPTOR, HUMAN;

ADULT; ARTICLE; BIRTH WEIGHT; BODY MASS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LABOR; MAJOR CLINICAL STUDY; MATERNAL OBESITY; PLACENTA; PRIORITY JOURNAL; SYNCYTIOTROPHOBLAST; UMBILICAL CORD BLOOD; BLOOD; CHEMISTRY; COMPARATIVE STUDY; ENDOTHELIUM CELL; FETUS BLOOD; GENETICS; MACROPHAGE; MALE; NEWBORN; OBESITY; PREGNANCY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; TROPHOBLAST;

ADULT; BIOMARKERS; BIRTH WEIGHT; BODY MASS INDEX; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FETAL BLOOD; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; LEPTIN; MACROPHAGES; MALE; OBESITY; PLACENTA; PREGNANCY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LEPTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS; TROPHOBLASTS;

EID: 84920763605     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719114537718     Document Type: Article

References (45)

1. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA . 2012;307(5):491-497.
2. Kristensen J, Vestergaard M, Wisborg K, Kesmodel U, Secher NJ. Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG. 2005;112(4):403-408.
3. Weiss JL, Malone FD, Emig D, et al. Obesity, obstetric complications and cesarean delivery rate - a population-based screening study. Am J Obstet Gynecol. 2004;190(4):1091-1097.
4. Ovesen P, Rasmussen S, Kesmodel U. Effect of prepregnancy maternal overweight and obesity on pregnancy outcome. Obstet Gynecol. 2011;118(2 pt 1):305-312.
5. Watkins ML, Rasmussen SA, Honein MA, Botto LD, Moore CA. Maternal obesity and risk for birth defects. Pediatrics. 2003;111(5 part 2):1152-1158.
6. Honein MA, Moore CA, Watkins ML. Subfertility and prepregnancy overweight/obesity: possible interaction between these risk factors in the etiology of congenital renal anomalies. Birth Defects Res A Clin Mol Teratol. 2003;67(8):572-577.
7. Stothard KJ, Tennant PW, Bell R, Rankin J. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA. 2009;301(6):636-650.
8. Whitaker RC. Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy. Pediatrics. 2004;114(1):e29-e36.
9. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290-e296.
10. Mohamed-Ali V, Pinkney JH, Coppack SW. Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord. 1998;22(12):1145-1158.
11. Briana DD, Malamitsi-Puchner A. Reviews: adipocytokines in normal and complicated pregnancies. Reprod Sci. 2009;16(10):921-937.
12. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395(6704):763-770.
13. Harris RB. Leptin - much more than a satiety signal. Annu Rev Nutr. 2000;20:45-75.
14. Tartaglia LA. The leptin receptor. J Biol Chem. 1997;272(10):6093-6096.
15. Zastrow O, Seidel B, Kiess W, et al. The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int J Obes Relat Metab Disord. 2003;27(12):1472-1478.
16. Bifulco G, Trencia A, Caruso M, et al. Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion. Placenta. 2003;24(4):385-391.
17. Perez-Perez A, Maymo J, Duenas JL, et al. Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway. Arch Biochem Biophys. 2008;477(2):390-395.
18. Dubern B, Clement K. Leptin and leptin receptor-related monogenic obesity. Biochimie. 2012;94(10):2111-2115.
19. Farooqi IS, Wangensteen T, Collins S, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med . 2007;356(3):237-247.
20. Ogier V, Ziegler O, Mejean L, Nicolas JP, Stricker-Krongrad A. Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans. Int J Obes Relat Metab Disord. 2002;26(4):496-503.
21. van Dielen FM, van't Veer C, Buurman WA, Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. J Clin Endocrinol Metab . 2002;87(4):1708-1716.
22. Hamed EA, Zakary MM, Ahmed NS, Gamal RM. Circulating leptin and insulin in obese patients with and without type 2 diabetes mellitus: relation to ghrelin and oxidative stress. Diabetes Res Clin Pract. 2011;94(3):434-441.
23. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes. 1996;45(11):1455-1462.
24. Hauguel-de Mouzon S, Lepercq J, Catalano P. The known and unknown of leptin in pregnancy. Am J Obstet Gynecol. 2006;194(6):1537-1545.
25. Senaris R, Garcia-Caballero T, Casabiell X, et al. Synthesis of leptin in human placenta. Endocrinology. 1997;138(10):4501-4504.
26. Masuzaki H, Ogawa Y, Sagawa N, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med. 1997;3(9):1029-1033.
27. Lea RG, Howe D, Hannah LT, Bonneau O, Hunter L, Hoggard N. Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod . 2000;6(8):763-769.
28. Linnemann K, Malek A, Schneider H, Fusch C. Physiological and pathological regulation of feto/placento/maternal leptin expression. Biochem Soc Trans. 2001;29(pt 2):86-90.
29. Farley DM, Choi J, Dudley DJ, et al. Placental amino acid transport and placental leptin resistance in pregnancies complicated by maternal obesity. Placenta . 2010;31(8):718-724.
30. Boeke CE, Mantzoros CS, Hughes MD, et al. Differential associations of leptin with adiposity across early childhood. Obesity (Silver Spring). 2013;21(7):1430-1437.
31. Matsuda J, Yokota I, Iida M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab. 1997;82(5):1642-1644.
32. Vela-Huerta MM, San Vicente-Santoscoy EU, Guizar-Mendoza JM, Amador-Licona N, Aldana-Valenzuela C, Hernnandez J. Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers. J Pediatr Endocrinol Metab. 2008;21(1):17-22.
33. Karakosta P, Chatzi L, Plana E, Margioris A, Castanas E, Kogevinas M. Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta-analysis. Paediatr Perinat Epidemiol . 2011;25(2):150-163.
34. Linnemann K, Malek A, Sager R, Blum WF, Schneider H, Fusch C. Leptin production and release in the dually in vitro perfused human placenta. J Clin Endocrinol Metab. 2000;85(11):4298-4301.
35. Lepercq J, Challier JC, Guerre-Millo M, Cauzac M, Vidal H, Hauguel-de Mouzon S. Prenatal leptin production: evidence that fetal adipose tissue produces leptin. J Clin Endocrinol Metab. 2001;86(6):2409-2413.
36. Schubring C, Englaro P, Siebler T, et al. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. Horm Res. 1998;50(5):276-283.
37. Challier J, Galtier M, Bintein T, Cortez A, Lepercq J, Hauguel-de Mouzon S. Placental leptin receptor isoforms in normal and pathological pregnancies. Placenta . 2003;24(1):92-99.
38. Li RH, Poon SC, Yu MY, Wong YF. Expression of placental leptin and leptin receptors in preeclampsia. Int J Gynecol Pathol. 2004;23(4):378-385.
39. Lewandowski K, Horn R, O'Callaghan CJ, et al. Free leptin, bound leptin, and soluble leptin receptor in normal and diabetic pregnancies. J Clin Endocrinol Metab. 1999;84(1):300-306.
40. Nuamah MA, Sagawa N, Yura S, et al. Free-to-total leptin ratio in maternal plasma is constant throughout human pregnancy. Endocr J. 2003;50(4):421-428.
41. Schulz S, Hackel C, Weise W. Hormonal regulation of neonatal weight: placental leptin and leptin receptors. BJOG. 2000;107(12):1486-1491.
42. Tome MA, Lage M, Camina JP, Garcia-Mayor RV, Dieguez C, Casanueva FF. Sex-based differences in serum leptin concentrations from umbilical cord blood at delivery. Eur J Endocrinol. 1997;137(6):655-658.
43. Yura S, Sagawa N, Mise H, et al. A positive umbilical venousarterial difference of leptin level and its rapid decline after birth. Am J Obstet Gynecol. 1998;178(5):926-930.
44. Lin KC, Hsu SC, Kuo CH, Zhou JY. Difference of plasma leptin levels in venous and arterial cord blood: relation to neonatal and placental weight. Kaohsiung J Med Sci. 1999;15(12):679-685.
45. Challier JC, Basu S, Bintein T, et al. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. 2008;29(3):274-281.