Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

Hepatology International

Volumn 9, Issue 1, 2015, Pages 93-104

  Vandewynckel, Yves Paul ^a   Laukens, Debby ^a   Bogaerts, Eliene ^a   Paridaens, Annelies ^a   Van den Bussche, Anja ^a   Verhelst, Xavier ^a   Van Steenkiste, Christophe ^a   Descamps, Benedicte ^a   Vanhove, Chris ^a,b   Libbrecht, Louis ^a   De Rycke, Riet ^b,c   Lambrecht, Bart N ^a,b,c   Geerts, Anja ^a   Janssens, Sophie ^a,b,c   Van Vlierberghe, Hans ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Unit for Medical Biotechnology Inflammation Research Centre (IRC) VIB UGent   (Belgium)

Author keywords

Endoplasmic reticulum; HepG2 cells; Inositol requiring enzyme 1; Liver neoplasm; PERK kinase; Stress

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CHAPERONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GSK 2656157; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN IRE1; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE; UNCLASSIFIED DRUG; ATF6 PROTEIN, MOUSE; DNAJC3 PROTEIN, MOUSE; ERN2 PROTEIN, MOUSE; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 40; MEMBRANE PROTEIN; MESSENGER RNA; MOLECULAR CHAPERONE GRP78; PERK KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; TUNICAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; HEPATOCELLULAR CARCINOMA CELL LINE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ADAPTATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; CELL TRANSFORMATION; CHEMISTRY; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENETICS; HEP-G2 CELL LINE; HUMAN; LIVER NEOPLASMS, EXPERIMENTAL; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; ULTRASTRUCTURE;

ACTIVATING TRANSCRIPTION FACTOR 6; ADAPTATION, PHYSIOLOGICAL; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; EIF-2 KINASE; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HEP G2 CELLS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84920760344     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-014-9582-0     Document Type: Article

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