Novel risk factors for recurrent clostridium difficile infection in children

Journal of Pediatric Gastroenterology and Nutrition

Volumn 60, Issue 1, 2015, Pages 18-22

  Nicholson, Maribeth R ^a   Thomsen, Isaac P ^a   Slaughter, James C ^b   Creech, C Buddy ^a   Edwards, Kathryn M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

antibiotic Associated diarrhea; Clostridium difficile; diarrhea; hospital Acquired infection; infectious colitis

Indexed keywords

ANTIBIOTIC AGENT; IMMUNOSUPPRESSIVE AGENT; STOMACH SECRETION INHIBITOR; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILD HOSPITALIZATION; CHILDHOOD CANCER; CHILDHOOD DISEASE; CHILDHOOD RECURRENT CLOSTRIDIUM DIFFICILE INFECTION; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; MALE; PATIENT HISTORY OF SURGERY; PEDIATRIC SURGERY; PRIORITY JOURNAL; RECURRENT INFECTION; RETROSPECTIVE STUDY; SCHOOL CHILD; ADOLESCENT; COHORT ANALYSIS; COMORBIDITY; DRUG EFFECTS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FOLLOW UP; GROWTH, DEVELOPMENT AND AGING; HOSPITAL; INFANT; ISOLATION AND PURIFICATION; MICROBIOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; PRESCHOOL CHILD; RECURRENT DISEASE; RISK FACTOR; TENNESSEE; TERTIARY CARE CENTER;

CLOSTRIDIUM DIFFICILE;

ADOLESCENT; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; COHORT STUDIES; COMORBIDITY; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FOLLOW-UP STUDIES; HOSPITALS, PEDIATRIC; HUMANS; INFANT; RECURRENCE; RETROSPECTIVE STUDIES; RISK FACTORS; TENNESSEE; TERTIARY CARE CENTERS;

EID: 84920738983     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000553     Document Type: Article

References (31)

1. Elliott B, Chang BJ, Golledge CL, et al. Clostridium difficile-Associated diarrhoea. Intern Med J 2007;37:561-8.
2. Zilberberg MD, Tillotson GS, McDonald C. Clostridium difficile infections among hospitalized children, United States, 1997-2006. Emerg Infect Dis 2010;16:604-9.
3. Khanna S, Baddour LM, Huskins WC, et al. The epidemiology of Clostridium difficile infection in children: a population-based study. Clin Infect Dis 2013;56:1401-6.
4. Kim J, Smathers SA, Prasad P, et al. Epidemiological features of Clostridium difficile-Associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics 2008;122:1266-70.
5. Kyne L, Kelly CP. Recurrent Clostridium difficile diarrhoea. Gut 2001;49:152-3.
6. McFarland LV, Surawicz CM, Greenberg RN, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994;271:1913-8.
7. Maroo S, Lamont JT. Recurrent Clostridium difficile. Gastroenterology 2006;130:1311-6.
8. McFarland LV, Surawicz CM, Rubin M, et al. Recurrent Clostridium difficile disease: epidemiology and clinical characteristics. Infect Control Hosp Epidemiol 1999;20:43-50.
9. McFarland LV, Elmer GW, Surawicz CM. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol 2002;97:1769-75.
10. Garey KW, Sethi S, Yadav Y, et al. Meta-Analysis to assess risk factors for recurrent Clostridium difficile infection. J Hosp Infect 2008;70:298-304.
11. Johnson S. Recurrent Clostridium difficile infection: a review of risk factors, treatments, and outcomes. J Infect 2009;58:403-10.
12. Eyre DW, Walker AS, Wyllie D, et al. Predictors of first recurrence of Clostridium difficile infection: implications for initial management. Clin Infect Dis 2012;55 (suppl 2):S77-87.
13. Kyne L, Warny M, Qamar A, et al. Association between antibody response to toxinA and protection against recurrent Clostridium difficile diarrhoea. Lancet 2001;357:189-93.
14. D'Agostino RB Sr, Collins SH, Pencina KM, et al. Risk estimation for recurrent Clostridium difficile infection based on clinical factors. Clin Infect Dis 2014;58:1386-93.
15. Tschudin-Sutter S, Tamma PD, Milstone AM, et al. Predictors of first recurrence of Clostridium difficile infections in children. Pediatr Infect Dis J 2014;33:414-6.
16. Jangi S, Lamont JT. Asymptomatic colonization by Clostridium difficile in infants: implications for disease in later life. J Pediatr Gastroenterol Nutr 2010;51:2-7.
17. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431-55.
18. Obeid JS, McGraw CA, Minor BL, et al. Procurement of shared data instruments for Research Electronic Data Capture (REDCap). J Biomed Inform 2013;46:259-65.
19. Zilberberg MD, Reske K, Olsen M, et al. Risk factors for recurrent Clostridium difficile infection (CDI) hospitalization among hospitalized patients with an initial CDI episode: a retrospective cohort study. BMC Infect Dis 2014;14:306.
20. O'Keefe SJ. Tube feeding, the microbiota, and Clostridium difficile infection. World J Gastroenterol 2010;16:139-42.
21. Lubbert C, Johann C, Kekule AS, et al. Immunosuppressive treatment as a risk factor for the occurrence of Clostridium difficile infection (CDI). Z Gastroenterol 2013;51:1251-8.
22. Zou H, Hastie T. Regularization and variable selection via the elastic net. J R Statist Soc B 2005;67:301-20.
23. Wu TT, Chen YF, Hastie T, et al. Genome-wide association analysis by lasso penalized logistic regression. Bioinformatics 2009;25:714-21.
24. Linsky A, Gupta K, Lawler EV, et al. Proton pump inhibitors and risk for recurrent Clostridium difficile infection. Arch Intern Med 2010;170: 772-8.
25. Rotramel A, Poritz LS, Messaris E, et al. PPI therapy and albumin are better predictors of recurrent Clostridium difficile colitis than choice of antibiotics. J Gastrointest Surg 2012;16:2267-73.
26. Hojsak I, Ferenc T, Bojanic K, et al. Incidence of Clostridium difficile infection in children with inflammatory bowel disease compared to oncology and immunocompetent patients. Digestion 2012;86:6-11.
27. Zerey M, Paton BL, Lincourt AE, et al. The burden of Clostridium difficile in surgical patients in the United States. Surg Infect (Larchmt) 2007;8:557-66.
28. Babrowski T, Holbrook C, Moss J, et al. Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration. Ann Surg 2012;255:386-93.
29. Carignan A, Allard C, Pepin J, et al. Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strain. Clin Infect Dis 2008;46:1838-43.
30. Chang JY, Antonopoulos DA, Kalra A, et al. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-Associated diarrhea. J Infect Dis 2008;197:435-8.
31. Marsh JW, Arora R, Schlackman JL, et al. Association of relapse of Clostridium difficile disease with BI/NAP1/027. J Clin Microbiol 2012;50:4078-82.