Impaired function of CD19+CD24hiCD38hi regulatory B cells in patients with pemphigus

British Journal of Dermatology

Volumn 172, Issue 1, 2015, Pages 101-110

  Zhu, H Q ^a   Xu, R C ^a   Chen, Y Y ^a   Yuan, H J ^a   Cao, H ^a   Zhao, X Q ^a   Zheng, J ^a   Wang, Y ^a   Pan, M ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; ANTIBODY; CD19 ANTIGEN; CD24 ANTIGEN; CD38 ANTIGEN; DESMOGLEIN;

ARTICLE; B LYMPHOCYTE; CD19+CD24 CD38 REGULATORY B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE FUNCTION; PATHOGENESIS; PEMPHIGUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TH1 CELL; ADULT; AGED; BIOSYNTHESIS; CASE CONTROL STUDY; CELL CULTURE; CELLULAR IMMUNITY; FEMALE; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; ANTIGENS, CD19; ANTIGENS, CD24; ANTIGENS, CD38; B-LYMPHOCYTES, REGULATORY; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DESMOGLEINS; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN-10; MALE; MIDDLE AGED; PEMPHIGUS;

EID: 84920720054     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13192     Document Type: Article

References (32)

1. Amagai M,. Pemphigus: autoimmunity to epidermal cell adhesion molecules. Adv Dermatol 1996; 11: 319-52.
2. Hertl M, Veldman C,. Pemphigus-paradigm of autoantibody-mediated autoimmunity. Skin Pharmacol Appl Skin Physiol 2001; 14: 408-18.
3. Stanley JR,. Autoantibodies against adhesion molecules and structures in blistering skin diseases. J Exp Med 1995; 181: 1-4.
4. Anhalt GJ, Labib RS, Voorhees JJ, et al,. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med 1982; 306: 1189-96.
5. Hertl M,. Humoral and cellular autoimmunity in autoimmune bullous skin disorders. Int Arch Allergy Immunol 2000; 122: 91-100.
6. Zhu H, Chen Y, Zhou Y, et al,. Cognate Th2-B cell interaction is essential for the autoantibody production in pemphigus vulgaris. J Clin Immunol 2012; 32: 114-23.
7. Yokoyama T, Amagai M,. Immune dysregulation of pemphigus in humans and mice. J Dermatol 2010; 37: 205-13.
8. Xu R, Zhu H, Li W, et al,. The imbalance of Th17 and regulatory T cells in pemphigus patients. Eur J Dermatol 2013; 23: 795-802.
9. Fujimoto M,. Regulatory B cells in skin and connective tissue diseases. J Dermatol Sci 2010; 60: 1-7.
10. Mauri C, Bosma A,. Immune regulatory function of B cells. Annu Rev Immunol 2012; 30: 221-41.
11. Mizoguchi A, Bhan AK,. A case for regulatory B cells. J Immunol 2006; 176: 705-10.
12. Fillatreau S, Sweenie CH, McGeachy MJ, et al,. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 2002; 3: 944-50.
13. Noh J, Lee JH, Noh G, et al,. Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br 1) in cow milk allergy. Cell Immunol 2010; 264: 143-9.
14. Lee JH, Noh J, Noh G, et al,. Allergen-specific transforming growth factor-beta-producing CD19+CD5+ regulatory B-cell (Br 3) responses in human late eczematous allergic reactions to cow's milk. J Interferon Cytokine Res 2011; 31: 441-9.
15. Noh J, Choi WS, Noh G, et al,. Presence of Foxp3-expressing CD19(+)CD5(+) B cells in human peripheral blood mononuclear cells: human CD19(+)CD5(+)Foxp3(+) regulatory b cell (Breg). Immune Netw 2010; 10: 247-9.
16. Matsushita T, Yanaba K, Bouaziz JD, et al,. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 2008; 118: 3420-30.
17. Mauri C, Gray D, Mushtaq N, et al,. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003; 197: 489-501.
18. Watanabe R, Ishiura N, Nakashima H, et al,. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol 2010; 184: 4801-9.
19. Blair PA, Noreña LY, Flores-Borja F, et al,. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010; 32: 129-40.
20. Knippenberg S, Peelen E, Smolders J, et al,. Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission. J Neuroimmunol 2011; 239: 80-6.
21. Kneisel A, Hertl M,. Autoimmune bullous skin diseases. Part 2: diagnosis and therapy. J Dtsch Dermatol Ges 2011; 9: 927-47.
22. Veldman C, Stauber A, Wassmuth R,. Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles. J Immunol 2003; 170: 635-42.
23. Zha B, Wang L, Liu X, et al,. Decrease in proportion of CD19+ CD24(hi) CD27+ B cells and impairment of their suppressive function in Graves' disease. PLoS ONE 2012; 7: e49835.
24. Kessel A, Haj T, Peri R, et al,. Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells. Autoimmun Rev 2012; 11: 670-7.
25. Colliou N, Picard D, Caillot F, et al,. Long-term remissions of severe pemphigus after rituximab therapy are associated with prolonged failure of desmoglein B cell response. Sci Transl Med 2013; 5: 175ra130.
26. Iwata Y, Matsushita T, Horikawa M, et al,. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011; 117: 530-41.
27. Sugiyama H, Matsue H, Nagasaka A, et al,. CD4+CD25high regulatory T cells are markedly decreased in blood of patients with pemphigus vulgaris. Dermatology 2007; 214: 210-20.
28. Veldman C, Höhne A, Dieckmann D,. Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris. J Immunol 2004; 172: 6468-75.
29. DiLillo DJ, Matsushita T, Tedder TF,. B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci 2010; 1183: 38-57.
30. Yanaba K, Bouaziz JD, Matsushita T,. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 2009; 182: 7459-72.
31. Bouaziz JD, Calbo S, Maho-Vaillant M,. IL-10 produced by activated human B cells regulates CD4(+) T-cell activation in vitro. Eur J Immunol 2010; 40: 2686-91.
32. Yoshizaki A, Miyagaki T, DiLillo DJ, et al,. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 2012; 491: 264-8.