Recombinant gelatin hydrogels for the sustained release of proteins

Journal of Controlled Release

Volumn 119, Issue 3, 2007, Pages 301-312

  Sutter, Marc ^a,b   Siepmann, Juergen ^c   Hennink, Wim E ^b   Jiskoot, Wim ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIV LILLE   (France)

Author keywords

Diffusion; Hydrogels; Protein delivery; Recombinant gelatin; Sustained release

Indexed keywords

AMINO ACIDS; BIODEGRADABILITY; CROSSLINKING; FREE RADICAL POLYMERIZATION; PHYSIOLOGY; POLYMERS; PROTEINS;

GEL FORMATION; GELATIN HYDROGELS; METHACRYLATED; RECOMBINANT GELATIN; SUSTAINED RELEASE;

HYDROGELS;

AMINE; BIOPOLYMER; GELATIN; INTERSTITIAL COLLAGENASE; LYSOZYME; METHACRYLIC ACID; POLYMER; PROTEIN; TRYPSIN INHIBITOR;

ARTICLE; BIODEGRADABILITY; CROSS LINKING; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DYNAMICS; ENZYME DEGRADATION; FRACTIONATION; GELATION; HYDROGEL; PHYSIOLOGY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN INTERACTION; SUSTAINED DRUG RELEASE;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, GEL; COLLAGEN TYPE I; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GELATIN; HUMANS; HYDROGELS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 9; METHACRYLATES; MOLECULAR SEQUENCE DATA; PROTEINS; RECOMBINANT PROTEINS; RHEOLOGY;

EID: 34249098497     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.03.003     Document Type: Article

References (58)

1. Egrie J.C., and Brown J.K. Development and characterization of a novel erythropoiesis stimulating protein (nesp). Br. J. Cancer 84 Supplement 1 (2001) 3-10
2. Long D.L., Doherty D.H., Eisenberg S.P., Smith D.J., Rosendahl M.S., Christensen K.R., Edwards D.P., Chlipala E.A., and Cox G.N. Design of homogeneous, monopegylated erythropoietin analogs with preserved in-vitro bioactivity. Exp. Hematol. 34 (2006) 697-704
3. Walsh G. Second-generation biopharmaceuticals. Eur. J. Pharm. Biopharm. 58 (2004) 185-196
4. Schellekens H. Factors influencing the immunogenicity of therapeutic proteins. Nephrol. Dial. Transplant. 20 Supplement 6 (2005) 3-9
5. Gribben J.G., Devereux S., Thomas N.S.B., Keim M., Jones H.M., Goldstone A.H., and Linch D.C. Development of antibodies to unprotected glycosylation sites on recombinant human gm-csf. Lancet 335 (1990) 434-437
6. Karpusas M., Whitty A., Runkel L., and Hochman P. The structure of human interferon-β: implications for activity. Cell. Mol. Life Sci. 54 (1998) 1203-1216
7. Hermeling S., Crommelin D.J.A., Schellekens H., and Jiskoot W. Structure-immunogenicity relationships of therapeutic proteins. Pharm. Res. 21 (2004) 897-903
8. Hennink W.E., and van Nostrum C.F. Novel crosslinking methods to design hydrogels. Adv. Drug Deliv. Rev. 54 (2002) 13-36
9. Peppas N.A., Bures P., Leobandung W., and Ichikawa H. Hydrogels in pharmaceutical formulations. Eur. J. Pharm. Biopharm. 50 (2000) 27-46
10. Sinha V.R., and Trehan A. Biodegradable microspheres for protein delivery. J. Control. Release 90 (2003) 261-280
11. Gombotz W.R., and Pettit D.K. Biodegradable polymers for protein and peptide drug delivery. Bioconjug. Chem. 6 (1995) 332-351
12. Packhaeuser C.B., Schnieders J., Oster C.G., and Kissel T. In situ forming parenteral drug delivery systems: an overview. Eur. J. Pharm. Biopharm. 58 (2004) 445-455
13. Cadee J.A., de Groot C.J., Jiskoot W., den Otter W., and Hennink W.E. Release of recombinant human interleukin-2 from dextran-based hydrogels. J. Control. Release 78 (2002) 1-13
14. de Jong S.J., van Eerdenbrugh B., van Nostrum C.F., Kettenes-van den Bosch J.J., and Hennink W.E. Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: degradation and protein release behavior. J. Control. Release 71 (2001) 261-275
15. Cadee J.A., van Luyn M.J., Brouwer L.A., Plantinga J.A., van Wachem P.B., de Groot C.J., den Otter W., and Hennink W.E. In vivo biocompatibility of dextran-based hydrogels. J. Biomed. Mater. Res. 50 (2000) 397-404
16. Park H., and Park K. Biocompatibility issues of implantable drug delivery systems. Pharm. Res. 13 (1996) 1770-1776
17. van Dijk-Wolthuis W.N.E., Hoogeboom J.A.M., van Steenbergen M.J., Tsang S.K.Y., and Hennink W.E. Degradation and release behavior of dextran-based hydrogels. Macromolecules 30 (1997) 4639-4645
18. Tabata Y., and Ikida Y. Protein release from gelatin matrices. Adv. Drug Deliv. Rev. 31 (1998) 287-301
19. Olsen D., Yang C., Bodo M., Chang R., Leigh S., Baez J., Carmichael D., Perälä M., Hämäläinen E.R., Jarvinen M., and Polarek J. Recombinant collagen and gelatin for drug delivery. Adv. Drug Deliv. Rev. 55 (2003) 1547-1567
20. Werten M.W.T., van den Bosh T.J., Wind R., Mooibroek H., and de Wolf F.A. High-yield secretion of recombinant gelatins by Pichia pastoris. Yeast 15 (1999) 1087-1096
21. Werten M.W.T., Wisselink W.H., Jansen-van den Bosh T.J., de Bruin E.C., and de Wolf F.A. Secreted production of a custom designed, highly hydrophilic gelatin in Pichia pastoris. Protein Eng. 14 (2001) 447-454
22. Gelse K., Pöschl E., and Aigner T. Collagens - structure, function, and biosynthesis. Adv. Drug Deliv. Rev. 55 (2003) 1531-1546
23. Ramzi A., Sutter M., Hennink W.E., and Jiskoot W. Static light scattering and small-angle neutron scattering study on aggregated recombinant gelatin in aqueous solution. J. Pharm. Sci. 95 (2006) 1703-1711
24. Pace C.N., Vajdos F., Fee L., Grimsley G., and Gray T. How to measure and predict the molar absorption coefficient of a protein. Protein Sci. 4 (1995) 2411-2423
25. Burova T.V., Varfolomeeva E.P., Grinberg V.A., Haertle T., and Tolstoguzov V.B. Effects of polysaccharides on the stability and renaturation of soybean trypsin (kunitz) inhibitor. Macromol. Biosci. 2 (2002) 286-292
26. Van Den Bulcke A.I., Bogdanov B., De Rooze N., Schacht E.H., Cornelissen M., and Berghmans H. Structural and rheological properties of methacrylamide modified gelatin hydrogels. Biomacromolecules 1 (2000) 31-38
27. Gekko K., and Hasegawa Y. Compressibiltiy-structure relationship of globular proteins. Biochemistry 25 (1986) 6563-6571
28. Meyvis T.K.L., Stubbe B.G., van Steenbergen M.J., Hennink W.E., De Smedt S.C., and Demeester J. A comparison between the use of dynamic mechanical analysis and oscillatory shear rheometry for the characterisation of hydrogels. Int. J. Pharm. 244 (2002) 163-168
29. Graessly W.W. Viscoelasticity and flow in polymeric liquids. In: Mark J.E., Ngai K.L., Graessly W.W., Mandelkern L., Samulski E.T., Koenig J.L., and Wignall G.D. (Eds). Physical Properties of Polymers, (2004), Cambridge University Press, Cambridge 153-208
30. Stenekes R.J., De Smedt S.C., Demeester J., Sun G., Zhang Z., and Hennink W.E. Pore sizes in hydrated dextran microspheres. Biomacromolecules 1 (2000) 696-703
31. Mwangi J.W., and Ofner C.M. Crosslinked gelatin matrices: release of a random coil macromolecular solute. Int. J. Pharm. 278 (2004) 319-327
32. Veis A. The Macromolecular Chemistry of Gelatin (1964), Academic Press, New York
33. Ghaderi R., and Calfors J. Biological activity of lysozyme after entrapment in poly(d,l-lactide-co-glycolyde)-microspheres. Pharm. Res. 14 (1997) 1556-1562
34. Siepmann J., Ainaoui A., Vergnaud J.M., and Bodmeier R. Calculation of the dimensions of drug-polymer devices based on diffusion parameters. J. Pharm. Sci. 87 (1998) 827-832
35. Okada Y., Gonoji Y., Naka K., Tomita K., Nakanishi I., Iwata K., Yamashita K., and Hayakawa T. Matrix metalloproteinase 9 (92-kDa gelatinase/type iv collagenase) from ht1080 human fibrosarcoma cells. J. Biol. Chem. 267 (1992) 21712-21719
36. March J. Advanced Organic Chemistry. Reactions, Mechanisms, and Structure (1992), John Wiley & Sons, New York
37. Furthmayr H., and Timpl R. Characterization of collagen peptides by sodium dodecylsulfate-polyacrylamide electrophoresis. Anal. Biochem. 41 (1971) 510-516
38. Hennink W.E., Talsma H., Borchert J.C.H., De Smedt S.C., and Demeester J. Controlled release of proteins from dextran hydrogels. J. Control. Release 39 (1996) 47-55
39. Leach B.S., and Fish W.W. Resistance of soybean trypsin inhibitor (kunitz) to denaturation by guanidinium chloride. J. Biol. Chem. 252 (1977) 5239-5243
40. Sharma U., and Carbeck J.D. Hydrodynamic radius ladders of proteins. Electrophoresis 26 (2005) 2086-2091
41. Lin C.C., and Metters A.T. Hydrogels in controlled release formulations: network design and mathematical modeling. Adv. Drug Deliv. Rev. 58 (2006) 1379-1408
42. 2 solutions from dynamic light-scattering data: effect of protein and salt concentrations. J. Phys. Chem., B 104 (2000) 3645-3650
43. Peppas N.A., and Reinhart C.T. Solute diffusion in swollen membranes. Part i. A new theory. J. Membr. Sci. 15 (1983) 275-287
44. Colton C.K., Smith K.A., Merrill E.W., and Farrell P.C. Permeability studies with cellulosic membranes. J. Biomed. Mater. Res. 5 (1971) 459
45. Johnson E.M., Berk D.A., Jain R.K., and Deen W.M. Diffusion and partitioning of proteins in charged agarose gels. Biophys. J. 68 (1995) 1561-1568
46. Hirota N., Kumaki Y., Narita T., Gong J.P., and Osada Y. Effect of charge on protein diffusion in hydrogels. J. Phys. Chem., B 104 (2000) 9898-9903
47. Zhang S., and Sun Y. Ionic strength dependence of protein adsorption to dye-ligand adsorbents. AIChE J. 48 (2002) 178-186
48. Kunitz M. Isolation of a crystalline protein compound of trypsin and of soybean trypsin-inhibitor. J. Gen. Physiol. 30 (1947) 311-320
49. Zschoernig O., Paasche G., Thieme C., Kolb N., and Arnold K. Modulation of lysozyme charge influences interaction with phospholipid vesicles. Colloids Surf., B Biointerfaces 42 (2005) 69-78
50. Yamamoto M., Ikada Y., and Tabata Y. Controlled release of growth factors based on biodegradation of gelatin hydrogel. J. Biomater. Sci., Polym. Ed. 12 (2001) 77-88
51. Kuijpers A.J., Engbers G.H.M., Meyvis T.K.L., De Smedt S.C., Demeester J., Krijgsveld J., Zaat S.A.J., Dankert J., and Feijen J. Combined gelatin-chondroitin sulfate hydrogels for controlled release of cationic antibacterial proteins. Macromolecules 33 (2000) 3705-3713
52. Hennink W.E., Franssen O., van Dijk-Wolthuis W.N.E., and Talsma H. Dextran hydrogels for the controlled release of proteins. J. Control. Release 48 (1997) 107-114
53. Cadee J.A., van Steenbergen M.J., Versluis C., Heck A.J.R., Underberg W.J.M., den Otter W., Jiskoot W., and Hennink W.E. Oxidation of recombinant interleukin-2 by potassium peroxodisulfate. Pharm. Res. 18 (2001) 1461-1467
54. Hermeling S., Crommelin D.J., Schellekens H., and Jiskoot W. Structure-immunogenicity relationships of therapeutic proteins. Pharm. Res. 21 (2004) 897-903
55. Pardo A., and Selman M. Mmp1: the elder of the family. Int. J. Biochem. Cell Biol. 37 (2005) 283-288
56. Van Den Steen P.E., Dubois B., Nelissen I., Rudd P.M., Dwek R.A., and Opendakker G. Biochemistry and molecular biology of gelatinase b or matrix metalloproteinase-9 (mmp-9). Crit. Rev. Biochem. Mol. Biol. 37 (2002) 375-536
57. Ohya S., and Nakayama Y. In vivo evaluation of poly(n-isopropylacrylamide) (pnipam)-grafted gelatin as an in-situ formable scaffold. J. Artif. Organs 7 (2004) 181-186
58. Morikawa N., and Matsuda T. Thermoresponsive artificial extracellular matrix: N-isopropylacrylamide-graft-copolymerized gelatin. J. Biomater. Sci., Polym. Ed. 13 (2002) 167-183