Pregnancy/obesity

Dyspnea: Mechanisms, Measurement, and Management, Third Edition

Volumn , Issue , 2014, Pages 39-53

  Jensen, Dennis ^a   O'Donnell, Denis E ^b  

^a MCGILL UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84920717152     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (94)

1. Dempsey JA, Adams L, Ainsworth DM, Gregosi RF, Gallagher CG, Guz A, Johnson BD, Powers SK. Airway, lung, and respiratory function during exercise. In Rowell LB, Shephard JT, editors. Handbook of Physiology. New York: Oxford University Press; 1996. pp. 448-514.
2. Dempsey JA, Miller JD, Romer LE. The respiratory system. In Tipton CM, Sawka MN, Tate CA, Terjung RL, editors. ACSM's Advanced Exercise Physiology. Baltimore, MD: Lippincott, Williams and Wilkins; 2006. pp. 246-99.
3. Sheel AW, Romer LM. Ventilation and respiratory mechanics. Comprehensive Physiology. 2012;2:1093-142.
4. Henke KG, Sharratt M, Pegelow D, Dempsey JA. Regulation of end-expiratory lung volume during exercise. Journal of Applied Physiology 1988;64(1):135-46.
5. Sharratt MT, Henke KG, Aaron EA, Pegelow DF, Dempsey JA. Exercise-induced changes in functional residual capacity. Respiration Physiology. 1987;70(3):313-26.
6. Younes M. Determinants of thoracic excursions during exercise. In Whipp BJ, Wasserman K, editors. Lung Biology in Health and Disease Exercise Pulmonary Physiology and Pathophysiology. New York: Marcel Dekker; 1991. pp. 1-65.
7. Romer LM, Polkey MI. Exercise-induced respiratory muscle fatigue: Implications for performance. Journal of Applied Physiology. 2008;104(3):879-88.
8. Jensen D, O'Donnell DE, Li R, Luo YM. Effects of dead space loading on neuro-muscular and neuro-ventilatory coupling of the respiratory system during exercise in healthy adults: Implications for dyspnea and exercise tolerance. Respiratory Physiology and Neurobiology. 2011;179(2-3):219-26.
9. Killian KJ, Summers E, Jones NL, Campbell EJ. Dyspnea and leg effort during incremental cycle ergometry. American Review of Respiratory Disease. 1992;145(6):1339-45.
10. Hamilton AL, Killian KJ, Summers E, Jones NL. Symptom intensity and subjective limitation to exercise in patients with cardiorespiratory disorders. Chest. 1996;110(5):1255-63.
11. Jones NL, Killian KJ. Exercise limitation in health and disease. New England Journal of Medicine. 2000;343(9):632-41.
12. Jensen D, Ofir D, O'Donnell DE. Effects of pregnancy, obesity and aging on the intensity of perceived breathlessness during exercise in healthy humans. Respiratory Physiology and Neurobiology. 2009;167(1):87-100.
13. O'Donnell DE, O'Donnell CD, Webb KA, Guenette JA. Respiratory consequences of mild-to-moderate obesity: Impact on exercise performance in health and in chronic obstructive pulmonary disease. Pulmonary Medicine. 2012;2012:818925.
14. Milne JA, Howie AD, Pack AI. Dyspnoea during normal pregnancy. British Journal of Obstetrics and Gynaecology. 1978;85(4):260-3.
15. Lemos A, de Souza AI, Figueiroa JN, Cabral-Filho JE, de Andrade AD. Respiratory muscle strength in pregnancy. Respiratory Medicine. 2010;104(11):1638-44.
16. Jensen D, Webb KA, O'Donnell DE. Chemical and mechanical adaptations of the respiratory system at rest and during exercise in human pregnancy. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. 2007;32(6):1239-50.
17. Weinberger SE, Weiss ST, Cohen WR, Weiss JW, Johnson TS. Pregnancy and the lung. American Review of Respiratory Disease. 1980;121(3):559-81.
18. Crapo RO. Normal cardiopulmonary physiology during pregnancy. Clinical Obstetrics and Gynecology. 1996; 39(1):3-16.
19. Hegewald MJ, Crapo RO. Respiratory physiology in pregnancy. Clinics in Chest Medicine. 2011;32(1):1-13, vii.
20. Wise RA, Polito AJ, Krishnan V. Respiratory physiologic changes in pregnancy. Immunology and Allergy Clinics of North America. 2006;26(1):1-12.
21. Elkus R, Popovich J, Jr. Respiratory physiology in pregnancy. Clinics in Chest Medicine. 1992;13(4):555-65.
22. Moore LG, McCullough RE, Weil JV. Increased HVR in pregnancy: Relationship to hormonal and metabolic changes. Journal of Applied Physiology. 1987;62(1):158-63.
23. Jensen D, Webb KA, Davies GA, O'Donnell DE. Mechanisms of activity-related breathlessness in healthy human pregnancy. European Journal of Applied Physiology. 2009;106(2):253-65.
24. Garcia-Rio F, Pino JM, Gomez L, Alvarez-Sala R, Villasante C, Villamor J. Regulation of breathing and perception of dyspnea in healthy pregnant women. Chest. 1996;110(2):446-53.
25. Jensen D, O'Donnell DE. The impact of human pregnancy on perceptual responses to chemoreflex vs. exercise stimulation of ventilation: A retrospective analysis. Respiratory Physiology and Neurobiology. 2011;175(1):55-61.
26. Jensen D, Webb KA, Davies GA, O'Donnell DE. Mechanical ventilatory constraints during incremental cycle exercise in human pregnancy: Implications for respiratory sensation. Journal of Physiology. 2008;586(Pt 19):4735-50.
27. Jensen D, Webb KA, Wolfe LA, O'Donnell DE. Effects of human pregnancy and advancing gestation on respiratory discomfort during exercise. Respiratory Physiology and Neurobiology. 2007;156(1):85-93.
28. Lehman V. Dyspnea in pregnancy. Journal of Perinatal Medicine. 1975(3):154-60.
29. Bader RA, Bader ME, Rose DJ. The oxygen cost of breathing in dyspnoeic subjects as studied in normal pregnant women. Clinical Science. 1959;18:223-35.
30. Gilbert R, Auchincloss JH, Jr. Dyspnea of pregnancy. Clinical and physiological observations. American Journal of the Medical Sciences. 1966;252(3):270-6.
31. Gilbert R, Epifano L, Auchincloss JH, Jr. Dyspnea of pregnancy. A syndrome of altered respiratory control. Journal of the American Medical Association. 1962;182:1073-7.
32. Marx GF, Murthy PK, Orkin LR. Static compliance before and after vaginal delivery. British Journal of Anaesthesia. 1970;42(12):1100-4.
33. Farman JV, Thorpe MH. Compliance changes during caesarean section. A study of forty cases. British Journal of Anaesthesia. 1969;41(11):999-1001.
34. Berry MJ, McMurray RG, Katz VL. Pulmonary and ventilatory responses to pregnancy, immersion, and exercise. Journal of Applied Physiology. 1989;66(2):857-62.
35. Gilroy RJ, Mangura BT, Lavietes MH. Rib cage and abdominal volume displacements during breathing in pregnancy. American Review of Respiratory Disease. 1988;137(3):668-72.
36. Contreras G, Gutierrez M, Beroiza T, Fantin A, Oddo H, Villarroel L, et al. Ventilatory drive and respiratory muscle function in pregnancy. American Review of Respiratory Disease. 1991;144(4):837-41.
37. Jensen D, Duffin J, Lam YM, Webb KA, Simpson JA, Davies GA, et al. Physiological mechanisms of hyperventilation during human pregnancy. Respiratory Physiology and Neurobiology. 2008;161(1):76-86.
38. Field SK, Bell SG, Cenaiko DF, Whitelaw WA. Relationship between inspiratory effort and breathlessness in pregnancy. Journal of Applied Physiology. 1991;71(5):1897-902.
39. Gee JB, Packer BS, Millen JE, Robin ED. Pulmonary mechanics during pregnancy. Journal of Clinical Investigation. 1967;46(6):945-52.
40. Garrard GS, Littler WA, Redman CW. Closing volume during normal pregnancy. Thorax. 1978;33(4):488-92.
41. Lyons HA, Antonio, R. The sensitivity of the respiratory center in pregnancy and after the administration of progesterone. Transactions of the Association of American Physicians. 1959;72:173-80.
42. Liberatore SM, Pistelli R, Patalano F, Moneta E, Incalzi RA, Ciappi G. Respiratory function during pregnancy. Respiration; International Review of Thoracic Diseases. 1984;46(2):145-50.
43. Jensen D, Webb KA, O'Donnell DE. The increased ventilatory response to exercise in pregnancy reflects alterations in the respiratory control systems ventilatory recruitment threshold for CO2. Respiratory Physiology and Neurobiology. 2010;171(2):75-82.
44. Jensen D, Wolfe LA, Slatkovska L, Webb KA, Davies GA, O'Donnell DE. Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 2005;288(5):R1369-75.
45. O'Donnell DE, Ora J, Webb KA, Laveneziana P, Jensen D. Mechanisms of activity-related dyspnea in pulmonary diseases. Respiratory Physiology and Neurobiology. 2009;167(1):116-32.
46. Stevens GA, Singh GM, Lu Y, Danaei G, Lin JK, Finucane MM, et al. National, regional, and global trends in adult overweight and obesity prevalences. Population Health Metrics. 2012;10(1):22.
47. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al. National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011;377(9765):557-67.
48. Katzmarzyk PT, Mason C. Prevalence of class I, II and III obesity in Canada. Canadian Medical Association Journal = Journal de l'Association Medicale Canadienne. 2006;174(2):156-7.
49. Karason K, Lindroos AK, Stenlof K, Sjostrom L. Relief of cardiorespiratory symptoms and increased physical activity after surgically induced weight loss: Results from the Swedish Obese Subjects study. Archives of Internal Medicine. 2000;160(12):1797-802.
50. Sin DD, Jones RL, Man SF. Obesity is a risk factor for dyspnea but not for airflow obstruction. Archives of Internal Medicine. 2002;162(13):1477-81.
51. Zutler M, Singer JP, Omachi TA, Eisner M, Iribarren C, Katz P, et al. Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD. Primary Care Respiratory Journal: Journal of the General Practice Airways Group. 2012;21(2):194-201.
52. Romagnoli I, Laveneziana P, Clini EM, Palange P, Valli G, de Blasio F, et al. Role of hyperinflation vs. deflation on dyspnoea in severely to extremely obese subjects. Acta Physiologica (Oxford, England). 2008;193(4):393-402.
53. Sahebjami H. Dyspnea in obese healthy men. Chest. 1998;114(5):1373-7.
54. El-Gamal H, Khayat A, Shikora S, Unterborn JN. Relationship of dyspnea to respiratory drive and pulmonary function tests in obese patients before and after weight loss. Chest. 2005;128(6):3870-4.
55. Lotti P, Gigliotti F, Tesi F, Stendardi L, Grazzini M, Duranti R, et al. Respiratory muscles and dyspnea in obese nonsmoking subjects. Lung. 2005; 183(5):311-23.
56. Ingle L, Cleland JG, Clark AL. Body mass index is related to the perception of exertional breathlessness in patients presenting with dyspnoea of unknown origin. International Journal of Cardiology. 2012;157(2):300-3.
57. Salome CM, Munoz PA, Berend N, Thorpe CW, Schachter LM, King GG. Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects. International Journal of Obesity (London). 2008;32(3):502-9.
58. Ofir D, Laveneziana P, Webb KA, O'Donnell DE. Ventilatory and perceptual responses to cycle exercise in obese women. Journal of Applied Physiology. 2007;102(6):2217-26.
59. Collet F, Mallart A, Bervar JF, Bautin N, Matran R, Pattou F, et al. Physiologic correlates of dyspnea in patients with morbid obesity. International Journal of Obesity (London). 2007;31(4):700-6.
60. Babb TG, Ranasinghe KG, Comeau LA, Semon TL, Schwartz B. Dyspnea on exertion in obese women: Association with an increased oxygen cost of breathing. American Journal of Respiratory and Critical Care Medicine. 2008;178(2):116-23.
61. Bernhardt V, Wood HE, Moran RB, Babb TG. Dyspnea on exertion in obese men. Respiratory Physiology and Neurobiology. 2012.
62. Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. Journal of Applied Physiology. 2010;108(1):206-11.
63. Littleton SW. Impact of obesity on respiratory function. Respirology. 2012;17(1):43-9.
64. Pelosi P, Croci M, Ravagnan I, Tredici S, Pedoto A, Lissoni A, et al. The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesthesia and Analgesia. 1998;87(3):654-60.
65. Pelosi P, Croci M, Ravagnan I, Vicardi P, Gattinoni L. Total respiratory system, lung, and chest wall mechanics in sedated-paralyzed postoperative morbidly obese patients. Chest. 1996;109(1):144-51.
66. Pelosi P, Ravagnan I, Giurati G, Panigada M, Bottino N, Tredici S, et al. Positive end-expiratory pressure improves respiratory function in obese but not in normal subjects during anesthesia and paralysis. Anesthesiology. 1999;91(5):1221-31.
67. Naimark A, Cherniack RM. Compliance of the respiratory system and its components in health and obesity. Journal of Applied Physiology. 1960;15:377-82.
68. Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ. The total work of breathing in normal and obese men. Journal of Clinical Investigation. 1964;43:728-39.
69. Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest. 2006;130(3):827-33.
70. King GG, Brown NJ, Diba C, Thorpe CW, Munoz P, Marks GB, et al. The effects of body weight on airway calibre. European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology. 2005;25(5):896-901.
71. Steier J, Jolley CJ, Seymour J, Roughton M, Polkey MI, Moxham J. Neural respiratory drive in obesity. Thorax. 2009;64(8):719-25.
72. Pankow W, Podszus T, Gutheil T, Penzel T, Peter J, Von Wichert P. Expiratory flow limitation and intrinsic positive end-expiratory pressure in obesity. Journal of Applied Physiology. 1998;85(4):1236-43.
73. Ferretti A, Giampiccolo P, Cavalli A, Milic-Emili J, Tantucci C. Expiratory flow limitation and orthopnea in massively obese subjects. Chest. 2001;119(5):1401-8.
74. Kress JP, Pohlman AS, Alverdy J, Hall JB. The impact of morbid obesity on oxygen cost of breathing (VO(2RESP) at rest. American Journal of Respiratory and Critical Care Medicine. 1999;160(3):883-6.
75. Chlif M, Keochkerian D, Choquet D, Vaidie A, Ahmaidi S. Effects of obesity on breathing pattern, ventilatory neural drive and mechanics. Respiratory Physiology and Neurobiology. 2009;168(3):198-202.
76. Chlif M, Keochkerian D, Mourlhon C, Choquet D, Ahmaidi S. Noninvasive assessment of the tensiontime index of inspiratory muscles at rest in obese male subjects. International Journal of Obesity (London). 2005;29(12):1478-83.
77. Chlif M, Keochkerian D, Feki Y, Vaidie A, Choquet D, Ahmaidi S. Inspiratory muscle activity during incremental exercise in obese men. International Journal of Obesity (London). 2007;31(9):1456-63.
78. Holley HS, Milic-Emili J, Becklake MR, Bates DV. Regional distribution of pulmonary ventilation and perfusion in obesity. Journal of Clinical Investigation. 1967;46(4):475-81.
79. Barrera F, Hillyer P, Ascanio G, Bechtel J. The distribution of ventilation, diffusion, and blood flow in obese patients with normal and abnormal blood gases. American Review of Respiratory Disease. 1973;108(4):819-30.
80. Zavorsky GS, Hoffman SL. Pulmonary gas exchange in the morbidly obese. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity. 2008;9(4):326-39.
81. Narkiewicz K, Kato M, Pesek CA, Somers VK. Human obesity is characterized by a selective potentiation of central chemoreflex sensitivity. Hypertension. 1999;33(5):1153-8.
82. Kunitomo F, Kimura H, Tatsumi K, Kuriyama T, Watanabe S, Honda Y. Sex differences in awake ventilatory drive and abnormal breathing during sleep in eucapnic obesity. Chest. 1988;93(5):968-76.
83. Ge RL, Stone JA, Levine BD, Babb TG. Exaggerated respiratory chemosensitivity and association with SaO2 level at 3568 m in obesity. Respiratory Physiology and Neurobiology. 2005;146(1):47-54.
84. Dempsey JA, Reddan W, Balke B, Rankin J. Work capacity determinants and physiologic cost of weight-supported work in obesity. Journal of Applied Physiology. 1966;21(6):1815-20.
85. Lafortuna CL, Agosti F, Galli R, Busti C, Lazzer S, Sartorio A. The energetic and cardiovascular response to treadmill walking and cycle ergometer exercise in obese women. European Journal of Applied Physiology. 2008;103(6):707-17.
86. Babb TG, Korzick D, Meador M, Hodgson JL, Buskirk ER. Ventilatory response of moderately obese women to submaximal exercise. International Journal of Obesity. 1991;15(1):59-65.
87. Babb TG, DeLorey DS, Wyrick BL, Gardner PP. Mild obesity does not limit change in end-expiratory lung volume during cycling in young women. Journal of Applied Physiology. 2002;92(6):2483-90.
88. Seres L, Lopez-Ayerbe J, Coll R, Rodriguez O, Vila J, Formiguera X, et al. Increased exercise capacity after surgically induced weight loss in morbid obesity. Obesity (Silver Spring). 2006;14(2):273-9.
89. Whipp BJ, Davis JA. The ventilatory stress of exercise in obesity. American Review of Respiratory Disease. 1984;129(2 Pt 2):S90-2.
90. Hulens M, Vansant G, Lysens R, Claessens AL, Muls E. Exercise capacity in lean versus obese women. Scandinavian Journal of Medicine and Science in Sports. 2001;11(5):305-9.
91. Salvadori A, Fanari P, Tovaglieri I, Giacomotti E, Nibbio F, Belardi F, et al. Ventilation and its control during incremental exercise in obesity. Respiration: International Review of Thoracic Diseases. 2008;75(1):26-33.
92. DeLorey DS, Wyrick BL, Babb TG. Mild-to-moderate obesity: Implications for respiratory mechanics at rest and during exercise in young men. International Journal of Obesity (London). 2005;29(9):1039-47.
93. Wood HE, Semon TL, Comeau LA, Schwartz B, MacDougall RM, Klocko MN, et al. The ventilatory response to exercise does not differ between obese women with and without dyspnea on exertion. Advances in Experimental Medicine and Biology. 2008;605:514-8.
94. Deesomchok A, Fisher T, Webb KA, Ora J, Lam YM, Lougheed MD, et al. Effects of obesity on perceptual and mechanical responses to bronchoconstriction in asthma. American Journal of Respiratory and Critical Care Medicine. 2010;181(2):125-33.