Mechanisms of activity-related breathlessness in healthy human pregnancy

European Journal of Applied Physiology

Volumn 106, Issue 2, 2009, Pages 253-265

  Jensen, Dennis ^a,b   Webb, Katherine A ^a   Davies, Gregory A L ^a   O'Donnell, Denis E ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

Exercise; Maternal hyperventilation; Respiratory discomfort; Respiratory mechanics

Indexed keywords

ADULT; ARTICLE; BREATHING MECHANICS; BREATHING MUSCLE; CLINICAL ARTICLE; DYSPNEA; EXERCISE INTENSITY; EXERCISE TEST; FEMALE; GESTATIONAL DYSPNEA; HUMAN; HYPERVENTILATION; PERCEPTIVE THRESHOLD; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PUERPERIUM; THIRD TRIMESTER PREGNANCY;

ADULT; DYSPNEA; EXERCISE; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS;

EID: 67349170295     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-009-1015-8     Document Type: Article

References (43)

1. American Thoracic Society/European Respiratory Society (2002) ATS/ERS statement on respiratory muscle testing. Am J Respir Crit Care Med 166:518-624. doi: 10.1164/rccm.166.4.518
2. Beaver WL, Wasserman K, Whipp BJ (1986) A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60:2020-2027
3. Black LF, Hyatt RE (1969) Maximal respiratory pressure: Normal values and relationship to age and sex. Am Rev Respir Dis 99:696-702
4. Borg GAV (1982) Psychophysical basis of perceived exertion. Med Sci Sports Exerc 14:377-381
5. Briscoe WA, Dubois AG (1959) The relationship between airway resistance, airway conductance, and lung volumes in subjects of different age and body size. J Clin Invest 37:1270-1285
6. Burrows B, Kasik JE, Niden AH, Barclay WR (1961) Clinical usefulness of the single-breath diffusing capacity test. Am Rev Respir Dis 84:789-806
7. Crapo RO, Morris AH, Clayton PD, Nixon CR (1982) Lung volumes in healthy non-smoking adults. Bull Eur Physiopathol Respir 18:419-425
8. Cunningham DJC (1987) Review lecture: Studies on arterial chemoreceptors in man. J Physiol 384:1-26
9. Field SK, Bell SG, Cenaiko DF, Whitelaw WA (1991) Relationship between inspiratory effort and breathlessness in pregnancy. J Appl Physiol 71:1897-1902
10. Garcia-Rio F, Pino JM, Gomez L, Alvarez-Sala R, Villasante C, Villamor J (1996) Regulation of breathing and perception of dyspnea in healthy pregnant women. Chest 110:446-453. doi: 10.1378/chest.110.2.446
11. Hamilton AL, Killian KJ, Summers E, Jones NL (1995) Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders. Am J Respir Crit Care Med 152:2021-2031
12. Jennings AL, Davies AN, Higgins JPT, Gibbs JSR, Broadley KE (2002) A systematic review of the use of opioids in the management of dyspnoea. Thorax 57:939-944. doi: 10.1136/thorax.57.11.939
13. Jensen D, Wolfe LA, O'Donnell DE, Davies GAL (2005) Chemoreflex control of breathing during wakefulness in healthy men and women. J Appl Physiol 98:822-828. doi: 10.1152/japplphysiol.01208.2003
14. Jensen D, Webb KA, O'Donnell DE (2007) Chemical and mechanical adaptations of the respiratory system at rest and during exercise in human pregnancy. Appl Physiol Nutr Metab 32:1239-1250. doi: 10.1139/ H07-120
15. Jensen D, Amjadi K, Harris-McAllister V, Webb KA, O'Donnell DE (2008a) Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPD. Thorax 63:606-613. doi: 10.1136/ thx.2007.085993
16. Jensen D, Duffin J, Lam YM, Webb KA, Simpson JA, Davies GAL, Wolfe LA, O'Donnell DE (2008b) Physiological mechanisms of hyperventilation during human pregnancy. Respir Physiol Neurobiol 161:76-86. doi: 10.1016/ j.resp.2008.01.001
17. Jensen D, Webb KA, Davies GAL, O'Donnell DE (2008c) Mechanical ventilatory constraints during incremental cycle exercise in human pregnancy: Implications for respiratory sensation. J Physiol 86:4735-4750. doi: 10.1113/jphysiol.2008.158154
18. Jensen D, Ofir D, O'Donnell DE (2009) Effects of pregnancy, obesity and aging on the intensity of perceived breathlessness during exercise in healthy humans. Respir Physiol Neurobiol. doi: 10.1016/j.resp.2009.01.011
19. Jones NL (1997) Clinical exercise testing, 2nd edn. WB Saunders Co, Philadelphia, pp 124-149
20. Knudson RJ, Lebowitz MD, Holberg CJ, Burrows B (1983) Changes in normal maximal expiratory flow-volume curves with growth and aging. Am Rev Respir Dis 127:725-734
21. Lehman V (1975) Dyspnea in pregnancy. J Perinat Med 3:154-160
22. MacIntyre N, Crapo RO, Viegi G et al (2005) Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 26:720-735. doi: 10.1183/09031936.05.00034905
23. Mahler DA, Weinberg DH, Wells CK, Feinstein AR (1984) The measurement of dyspnea: Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 85:751-758. doi: 10.1378/ chest.85.6.751
24. McMurray RG, Berry MJ, Katz V (1990) The beta-endorphin response of pregnant women during aerobic exercise in the water. Med Sci Sports Exerc 22:298-303. doi: 10.1249/00005768-199006000-00005
25. Miller MR, Crapo R, Hankinson J et al (2005a) General considerations for lung function testing. Eur Respir J 26:153-161. doi: 10.1183/ 09031936.05.00034505
26. Miller MR, Hankinson J, Brusasco V et al (2005b) Standardisation of spirometry. Eur Respir J 26:319-338. doi: 10.1183/09031936.05.00034805
27. Milne JA, Howie AD, Pack AI (1978) Dyspnea during normal pregnancy. Br J Obstet Gynaecol 85:260-263
28. Moore LG, McCullough RE, Weil JV (1987) Increased HVR in pregnancy: relationship to hormonal and metabolic changes. J Appl Physiol 62:158-163
29. Morris JF, Koski A, Temple WP, Claremont A, Thomas DR (1988) Fifteen-year interval spirometric evaluation of the Oregon predictive equations. Chest 92:123-127. doi: 10.1378/chest.93.1.123
30. Nettlefold LA, Jensen D, Janssen I, Wolfe LA (2007) Ventilatory control and acid-base regulation across the menstrual cycle in oral contraceptive users. Respir Physiol Neurobiol 158:51-58. doi: 10.1016/ j.resp.2007.04.005
31. O'Donnell DE, Bertley JC, Chau LL, Webb KA (1997) Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms. Am J Respir Crit Care Med 155:109-115
32. O'Donnell DE, Lam M, Webb KA (1998) Measurement of symptoms, lung hyperinflation and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158:1557-1565
33. O'Donnell DE, Hong HH, Webb KA (2000) Respiratory sensation during chest wall restriction and dead space loading in exercising men. J Appl Physiol 88:1859-1869
34. O'Donnell DE, Hamilton AL, Webb KA (2006) Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J Appl Physiol 101:1025-1035. doi: 10.1152/japplphysiol.01470.2005
35. Preston ME, Jensen D, Janssen I, Fisher JT (2008) Effect of menopause on the chemical control of breathing and its relationship with acid-base status. Am J Physiol Regul Integ Comp Physiol. doi: 10/1152/ ajpregu.90865.2008
36. Sgherza AL, Axen K, Fain R, Hoffman RS, Dunbar CC, Haas F (2002) Effect of naloxone on perceived exertion and exercise capacity during maximal cycle ergometry. J Appl Physiol 93:2023-2028
37. Slatkovska L, Jensen D, Davies GAL, Wolfe LA (2006) Phasic menstrual cycle effects on the control of breathing in healthy women. Respir Physiol Neurobiol 154:379-388. doi: 10.1016/j.resp.2006.01.011
38. Stoller JK, Ferranti R, Feinstein AR (1986) Further specification and evaluation of a new clinical index for dyspnea. Am Rev Respir Dis 135:1129-1134
39. Stubbing DG, Pengelly LD, Morse JLC, Jones NL (1980) Pulmonary mechanics during exercise in normal males. J Appl Physiol 49:506-510
40. Tobin MJ (1998) Monitoring respiratory mechanics in spontaneously breathing patients. In: Tobin M (ed) Principles and practice of intensive care monitoring. McGraw-Hill Inc, New York, pp 617-654
41. Wanger J, Clausen JL, Coates A et al (2005) Standardisation of the measurement of lung volumes. Eur Respir J 26:511-522. doi: 10.1183/ 09031936.05.00035005
42. Wasserman K, Hansen JE, Sue DY, Stringer WW, Whipp BJ (2005) Principles of exercise testing and interpretation, 4th edn. Lippincott Williams & Wilkins, Baltimore, pp 86-90
43. Yan S, Kaminski D, Sliwinski P (1997) Reliability of inspiratory capacity for estimating end expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 156:55-59