Mechanical ventilatory constraints during incremental cycle exercise in human pregnancy: Implications for respiratory sensation

Journal of Physiology

Volumn 586, Issue 19, 2008, Pages 4735-4750

  Jensen, Dennis ^a,b   Webb, Katherine A ^a   Davies, Gregory A L ^a   O'Donnell, Denis E ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREATHING MUSCLE; BREATHING PATTERN; BRONCHODILATATION; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPNEA; ESOPHAGUS PRESSURE; EXERCISE; EXPIRATORY FLOW RATE; FEMALE; FORCED EXPIRATORY FLOW; HUMAN; INSPIRATORY CAPACITY; LUNG VENTILATION; LUNG VOLUME; MUSCLE STRENGTH; PREGNANCY; PRIORITY JOURNAL; RESPIRATORY FUNCTION; SENSATION; THIRD TRIMESTER PREGNANCY; TIDAL VOLUME; TOTAL LUNG CAPACITY; VITAL CAPACITY; ADAPTATION; AIRWAY; BREATHING; BREATHING MECHANICS; CYCLING; GESTATION PERIOD; HUMAN EXPERIMENT; LONGITUDINAL STUDY; LUNG RESISTANCE; NORMAL HUMAN; PUERPERIUM; RESPIRATORY SYSTEM; REST;

ADULT; DYSPNEA; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; LONGITUDINAL STUDIES; PREGNANCY; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS; YOUNG ADULT;

EID: 53249137859     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.158154     Document Type: Article

References (70)

1. Agostoni E & Mead J (1964). Statics of the respiratory system. In Handbook of Physiology, section 3, vol. 1, Respiration, ed. Fehn WO & Rahn H, pp. 387-409. American Physiological Society, Washington, DC, USA.
2. American Thoracic Society/European Respiratory Society (2002). ATS/ERS statement on respiratory muscle testing. Am J Respir Crit Care Med 166, 518-624.
3. Avery ND, Wolfe LA, Amara CE, Davies GAL & McGrath MJ (2001). Effects of human pregnancy on cardiac autonomic function above and below the ventilatory threshold. J Appl Physiol 90, 321-328.
4. Bader RA, Bader ME & Rose DJ (1959). The oxygen cost of breathing in dyspnoeic subjects as studied in normal pregnant women. Clin Sci 18, 223-235.
5. Baydur A, Behrakis PK, Zin WA, Jaeger M & Milic-Emili J (1982). A simple method for assessing the validity of the esophageal balloon technique. Am Rev Respir Dis 126, 788-791.
6. Beaver WL, Wasserman K & Whipp BJ (1986). A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60, 2020-2027.
7. Berry MJ, McMurray RG & Katz VL (1989). Pulmonary and ventilatory responses to pregnancy, immersion, and exercise. J Appl Physiol 66, 857-862.
8. Borg GA (1982). Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14, 377-381.
9. Briscoe WA & Dubois AG (1958). The relationship between airway resistance, airway conductance, and lung volume in subjects of different age and body size. J Clin Invest 37, 1279-1285.
10. Butler J, Caro CG, Alcala R & DuBois AB (1960). Physiological factors affecting airway resistance in normal subjects and in patients with obstructive respiratory disease. J Clin Invest 39, 584-591.
11. Chen Z, Eldridge FL & Wagner PG (1991). Respiratory-associated rhythmic firing of midbrain neurons in cats: Relation to level of respiratory drive. J Physiol 437, 305-325.
12. Chen Z, Eldridge FL & Wagner PG (1992). Respiratory-associated thalamic activity is related to the level of respiratory drive. Respir Physiol 90, 99-113.
13. Contreras G, Gutierrez M, Beroiza T, Fantin A, Oddo H, Villarroel L, Cruz E & Lisboa C (1991). Ventilatory drive and respiratory muscle function in pregnancy. Am Rev Respir Dis 144, 837-841.
14. Crapo RO, Morris AH, Clayton PD & Nixon CR (1982). Lung volumes in healthy non-smoking adults. Bull Eur Physiopath Respir 18, 419-425.
15. Davies GAL, Wolfe LA, Mottola MF & MacKinnon C (2003). Joint SOGC/ CSEP clinical practice guideline: Exercise in pregnancy and the post-partum period. Can J Appl Physiol 28, 330-341.
16. Field SK, Bell SG, Cenaiko DF & Whitelaw WA (1991). Relationship between inspiratory effort and breathlessness in pregnancy. J Appl Physiol 71, 1897-1902.
17. Foster PS, Goldie RG & Paterson JW (1983). Effects of steroids on β-adrenoreceptor-mediated relaxation of pig bronchus. Br J Pharmacol 78, 441-445.
18. Gandevia B & Hugh-Jones P (1957). Terminology for measurements of ventilatory capacity: A report to the thoracic society. Thorax 12, 290-293.
19. Garcia-Rio F, Pino JM, Gomez L, Alvarez-Sala R, Villasante C & Villamor J (1996). Regulation of breathing and perception of dyspnea in healthy pregnant women. Chest 110, 446-453.
20. Garcia-Rio F, Pino-Garcia JM, Serrano S, Racionero MA, Terreros-Caro JG, Alvarez-Sala R, Villasante C & Villamor J (1997). Comparison of helium dilution and plethysmographic lung volumes in pregnant women. Eur Respir J 10, 2371-2375.
21. Garrard GS, Littler WA & Redman CWG (1978). Closing volume during normal pregnancy. Thorax 33, 488-492.
22. Gee JBL, Packer BS, Millen JE & Robin ED (1967). Pulmonary mechanics during pregnancy. J Clin Invest 46, 945-952.
23. Gibson GJ & Pride NB (1976). Lung distensibility: The static pressure-volume curve of the lung and its use in clinical assessment. Br J Dis Chest 70, 143-184.
24. Gilbert R & Auchincloss JH (1966). Dyspnea of pregnancy: Clinical and physiological observations. Am J Med Sci 52, 270-276.
25. Gilbert R, Epifano L & Auchincloss JH (1962). Dyspnea of pregnancy: a syndrome of altered respiratory control. J Am Med Assoc 182, 1073-1077.
26. Gilroy RJ, Mangura BT & Lavietes MH (1988). Rib cage and abdominal volume displacements during breathing in pregnancy. Am Rev Respir Dis 137, 668-672.
27. Harty HR, Corfield DR, Schwartzstein RM & Adams L (1999). External thoracic restriction, respiratory sensation, and ventilation during exercise in men. J Appl Physiol 86, 1142-1150.
28. Hey EN, Lloyd BB, Cunningham DJC, Jukes MGM & Bolton DPG (1966). Effects of various respiratory stimuli on the depth and frequency of breathing in man. Respir Physiol 1, 193-205.
29. Ito S, Sasano H, Sasano N, Hayano J, Fisher JA & Katsuya H (2006). Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humans. Exp Physiol 91, 935-941.
30. Itoh M, Ueoka H, Aoki T, Hotta N, Kaneko Y, Takita C & Fukuoka Y (2007). Exercise hyperpnea and hypercapnic ventilatory responses in women. Respir Med 101, 446-452.
31. Jensen D, Duffin J, Lam YM, Webb KA, Simpson JA, Davies GAL, Wolfe LA & O'Donnell DE (2008). Physiological mechanisms of hyperventilation during human pregnancy. Respir Physiol Neurobiol 161, 76-86.
32. Jensen D, Webb KA & O'Donnell DE (2007a). Chemical and mechanical adaptations of the respiratory system at rest and during exercise in human pregnancy. Appl Physiol Nutr Metab 32, 1239-1250.
33. Jensen D, Webb KA, Wolfe LA & O'Donnell DE (2007b). Effects of human pregnancy and advancing gestation on respiratory discomfort during exercise. Respir Physiol Neurobiol 156, 85-93.
34. Jones NL (1997). Interpretation of stage 1 exercise test results. Clinical Exercise Testing, 4th edn, pp. 128-149. W.B. Saunders Co, Philadelphia, PA, USA.
35. Lotgering FK, Struijk PC, Van Doorn MB, Spinnewijn WEM & Wallenburg HCS (1995). Anaerobic threshold and respiratory compensation in pregnant women. J Appl Physiol 78, 1772-1777.
36. MacIntyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CPM, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Gustafsson P, Hankinson J, Jensen R, McKay R, Miller MR, Navajas D, Pedersen OF, Pellegrino R & Wanger J (2005). Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 26, 720-735.
37. Mahler DA, Weinberg DH, Wells CK & Feinstein AR (1984). The measurement of dyspnea: Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 85, 751-758.
38. Manning HL & Schwartzstein RM (1995). Pathophysiology of dyspnea. N Eng J Med 333, 1547-1553.
39. Marx GF, Murthy PK & Orkin LR (1970). Static compliance before and after vaginal delivery. Br J Anaesth 42, 1100-1104.
40. Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, van der Grinten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G & Wanger J (2005a). General considerations for lung function testing. Eur Respir J 26, 153-161.
41. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coastes A, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G & Wanger J (2005b). Standardisation of spirometry. Eur Respir J 26, 319-338.
42. Milne JA, Howie AD & Pack AI (1978). Dyspnea during normal pregnancy. Br J Obstet Gynaecol 85, 260-263.
43. Moore LG, McCullough RE & Weil JV (1987). Increased HVR in pregnancy: Relationship to hormonal and metabolic changes. J Appl Physiol 62, 158-163.
44. Nettlefold L, Jensen D, Wolfe LA & O'Donnell DE (2007). Ventilatory control and acid-base regulation across the menstrual cycle in oral contraceptive users. Respir Physiol Neurobiol 158, 51-58.
45. 2 tension on flow resistance. J Appl Physiol 19, 745-749.
46. O'Donnell DE, Banzett RB, Carrieri-Kohlman V, Casaburi R, Davenport PW, Gandevia SC, Gelb AG, Mahler DA & Webb KA (2007). Pathophysiology of dyspnea in chronic obstructive pulmonary disease: A roundtable. Proc Am Thorac Soc 4, 145-168.
47. O'Donnell DE, Bertley JC, Chau LL & Webb KA (1997). Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms. Am J Respir Crit Care Med 155, 109-115.
48. O'Donnell DE, Hamilton AL & Webb KA (2006). Sensory-mechanical relationships during high-intensity constant-work-rate exercise in COPD. J Appl Physiol 101, 1025-1035.
49. O'Donnell DE, Hong HH & Webb KA (2000). Respiratory sensation during chest wall restriction and dead space loading in exercising men. J Appl Physiol 88, 1859-1869.
50. O'Donnell DE, Lam M & Webb KA (1998). Measurement of symptoms, lung hyperinflation and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158, 1557-1565.
51. O'Donnell DE, Revill SM & Webb KA (2001). Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164, 770-777.
52. Ofir D, Laveneziana P, Webb KA, Lam YM & O'Donnell DE (2008). Sex differences in the perceived intensity of breathlessness during exercise with advancing age. J Appl Physiol 104, 1583-1593.
53. Ofir D, Laveneziana P, Webb KA & O'Donnell DE (2007). Ventilatory and perceptual responses to cycle exercise in obese women. J Appl Physiol 102, 2217-2226.
54. Otis AB (1964). The work of breathing. In Handbook of Physiology, section 3, vol. 1, Respiration, ed. Fehn WO & Rahn H, pp. 463-476. American Physiological Society, Washington, DC, USA.
55. Perusquia M, Hernandez R, Montano LM, Villalon CM & Campos MG (1997). Inhibitory effect of sex steroids on guinea-pig airway smooth muscle contractions. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 118, 5-10.
56. Popovic RM & White DP (1998). Upper airway muscle activity in normal women: Influence of hormonal status. J Appl Physiol 84, 1055-1062.
57. Redman LM, Scroop GC & Norman RJ (2003). Impact of menstrual cycle phase on the exercise status of young, sedentary women. Eur J Appl Physiol 90, 505-513.
58. Rubin A, Russo N & Goucher D (1956). The effect of pregnancy upon pulmonary function in normal women. Am J Obstet Gynecol 72, 963-969.
59. Sady SP, Carpenter MW, Thompson PD, Sady MA, Haydon B & Coustan DR (1989). Cardiovascular response to cycle exercise during and after pregnancy. J Appl Physiol 66, 336-341.
60. Severinghaus JW & Stupfel M (1955). Respiratory dead space increase following atropine in man, and atropine, vagal or ganglionic blockade and hypothermia in dogs. J Appl Physiol 8, 81-87.
61. Slatkovska L, Jensen D, Davies GAL & Wolfe LA (2006). Phasic menstrual cycle effects on the control of breathing in healthy women. Respir Physiol Neurobiol 154, 379-388.
62. Smekal G, Von Duvillard SP, Frigo P, Tegelhofer T, Pokan R, Hofmann P, Tschan H, Baron R, Wonisch M, Renezeder K & Bachl N (2007). Menstrual cycle: No effect on exercise cardiorespiratory variables or blood lactate concentration. Med Sci Sports Exerc 39, 1098-1106.
63. Sterling GM (1968). The mechanism of bronchoconstriction due to hypocapnia in man. Clin Sci 34, 277-285.
64. Stoller JK, Ferranti R & Feinstein AR (1986). Further specification and evaluation of a new clinical index for dyspnea. Am Rev Respir Dis 134, 1129-1134.
65. Stubbing DG, Pengelly LD, Morse JLC & Jones NL (1980). Pulmonary mechanics during exercise in normal males. J Appl Physiol 49, 506-510.
66. Thomson KJ & Cohen ME (1938). Studies on the circulation in pregnancy. II. Vital capacity observations in normal pregnant women. Surg Gynecol Obstet 66, 591-603.
67. Tobin MJ (1998). Monitoring respiratory mechanics in spontaneously breathing patients. In Principles and Practice of Intensive Care Monitoring, ed. Tobin MJ, pp. 617-654. McGraw-Hill, Inc., New York, NY, USA.
68. Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, Hankinson J, Jensen R, Johnson D, MacIntyre N, McKay R, Miller MR, Navajas D, Pellegrino R & Viegi G (2005). Standardisation of the measurement of lung volumes. Eur Respir J 26, 511-522.
69. Wasserman K, Hansen JE, Sue DY, Stringer WW & Whipp BJ (2005). Principles of Exercise Testing and Interpretation, 4th edn. Lippincott Williams & Wilkins, Baltimore, MD, USA.
70. Yan S, Kaminski D & Sliwinski P (1997). Reliability of inspiratory capacity for estimating end expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 156, 55-59.