Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions

Acta Biomaterialia

Volumn 13, Issue , 2015, Pages 42-51

  Kakinoki, Sachiro ^a,d   Seo, Ji Hun ^b,d   Inoue, Yuuki ^c,d   Ishihara, Kazuhiko ^c,d   Yui, Nobuhiko ^b,d   Yamaoka, Tetsuji ^a,d  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Cell adhesion; Cell differentiation; Molecular mobility; Polyrotaxane; RGDS

Indexed keywords

BLOCK COPOLYMERS; CELL ADHESION; CELL CULTURE; CHLORINE COMPOUNDS; DIMETHYL SULFOXIDE; ENDOTHELIAL CELLS; LIGANDS; PROTEINS; SUBSTRATES;

ACTIN FILAMENT; ARG GLY ASPS; CELL DIFFERENTIATION; CELLS ADHESION; FILAMENT FORMATION; INTEGRINS; MECHANOTRANSDUCTION; MOLECULAR MOBILITY; POLYROTAXANES; RGDS;

STEM CELLS;

ALPHA CYCLODEXTRIN; ARGINYLGLYCYLASPARTYLSERINE; COPOLYMER; INTEGRIN; LIGAND; POLY( 2 METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE CO N BUTYL METHACRYLATE); POLYROTAXANE; POLYROTAXANE ARGINYLGLYCYLASPARTYLSERINE; UNCLASSIFIED DRUG; ALPHA CYCLODEXTRIN DERIVATIVE; ARGINYL-GLYCYL-ASPARTYL-SERINE; CYCLODEXTRIN; OLIGOPEPTIDE; POLOXAMER; POLYMETHACRYLIC ACID DERIVATIVE; ROTAXANE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MOTILITY; CELL STRUCTURE; CLICK CHEMISTRY; COMPARATIVE STUDY; EMBRYONAL CARCINOMA; HUMAN; HUMAN CELL; HYDROPHILICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MECHANOTRANSDUCTION; NERVE FIBER GROWTH; NONHUMAN; PHEOCHROMOCYTOMA CELL; POLYMERIZATION; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; UMBILICAL VEIN ENDOTHELIAL CELL; YOUNG MODULUS; ANIMAL; CELL MOTION; CHEMISTRY; CYTOLOGY; METABOLISM; MOUSE; PC12 CELL LINE; STEM CELL;

RATTUS;

ACTIN CYTOSKELETON; ALPHA-CYCLODEXTRINS; ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; CYCLODEXTRINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MICE; OLIGOPEPTIDES; PC12 CELLS; POLOXAMER; POLYMETHACRYLIC ACIDS; RATS; ROTAXANES; STEM CELLS;

EID: 84920714337     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.11.020     Document Type: Article

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