Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1

Heart Rhythm

Volumn 12, Issue 1, 2015, Pages 220-228

  Kim, Tae Yun ^a   Kunitomo, Yukiko ^a   Pfeiffer, Zachary ^a   Patel, Divyang ^b   Hwang, Jungmin ^a,c   Harrison, Kathryn ^a   Patel, Brijesh ^a   Jeng, Paul ^a   Ziv, Ohad ^d   Lu, Yichun ^a   Peng, Xuwen ^e   Qu, Zhilin ^f   Koren, Gideon ^a   Choi, Bum Rak ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF RHODE ISLAND   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e PENN STATE COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Action potential duration dispersion; Bi excitability; Early afterdepolarization; Long QT syndrome; Optical mapping; Polymorphic ventricular tachycardia; Ventricular tachycardia

Indexed keywords

DYE; ISOPRENALINE; TETRODOTOXIN; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX EXCITATION DYNAMICS; COMPUTER SIMULATION; CONTROLLED STUDY; DYNAMICS; ELECTROCARDIOGRAM; EXCITATION; FEMALE; HEART; HEART LEFT VENTRICLE; HEART MUSCLE POTENTIAL; HEART RIGHT VENTRICLE; LONG QT SYNDROME 1; MALE; NONHUMAN; OSCILLATION; POLYMORPHIC VENTRICULAR TACHYCARDIA; PRIORITY JOURNAL; QRS COMPLEX; SODIUM CURRENT; TRANSGENIC RABBIT; ANIMAL; COMPLICATION; DISEASE MODEL; ELECTROCARDIOGRAPHY; HEART MUSCLE CONDUCTION SYSTEM; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT; ROMANO-WARD SYNDROME; TACHYCARDIA, VENTRICULAR; TRANSGENIC ANIMAL;

ACTION POTENTIALS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FEMALE; HEART CONDUCTION SYSTEM; MALE; POTASSIUM CHANNELS, VOLTAGE-GATED; RABBITS; ROMANO-WARD SYNDROME; TACHYCARDIA, VENTRICULAR;

EID: 84920699979     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.10.003     Document Type: Article

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